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UniProtKB - B4QBN3 (TRE12_DROSI)
Protein
Facilitated trehalose transporter Tret1-2 homolog
Gene
Tret1-2
Organism
Drosophila simulans (Fruit fly)
Status
Functioni
Fails to transport trehalose.
By similarityGO - Molecular functioni
- sugar transmembrane transporter activity Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Facilitated trehalose transporter Tret1-2 homologBy similarity |
Gene namesi | Name:Tret1-2By similarity ORF Names:GD10808 |
Organismi | Drosophila simulans (Fruit fly) |
Taxonomic identifieri | 7240 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysisBy similarity; Multi-pass membrane protein Sequence analysisBy similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 72 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 73 – 93 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 105 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 106 – 126 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 129 | ExtracellularSequence analysis | 3 | |
Transmembranei | 130 – 150 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 151 – 160 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 161 – 181 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 184 | ExtracellularSequence analysis | 3 | |
Transmembranei | 185 – 205 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 268 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 305 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 306 – 326 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 332 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 333 – 353 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 354 – 372 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 373 – 393 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 402 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 403 – 423 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 433 | ExtracellularSequence analysis | 10 | |
Transmembranei | 434 – 454 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 455 – 488 | CytoplasmicSequence analysisAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395536 | 1 – 488 | Facilitated trehalose transporter Tret1-2 homologAdd BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | B4QBN3 |
Expressioni
Gene expression databases
Bgeei | FBgn0182571, Expressed in adult organism and 4 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysisBy similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_001265_30_5_1 |
OMAi | VFQRLIM |
PhylomeDBi | B4QBN3 |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B4QBN3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILMRADTH VSYSVPAEGP KANFTFSQVL AALSVSLCSL VVGFVSAYTS
60 70 80 90 100
PALVSMTDRT ITSFEVTKDA GSWVGGIMPL AALAGGITGG PLIEYLGRRT
110 120 130 140 150
TILATAVPFI VSSLLIACAV NVIMILCGRF LTGFCVGIAS LSLPVYLGET
160 170 180 190 200
LQPEVRGTLG LLPTALGNIG ILVCYVAGSF MNWSMLAFLG AALPVPFLIL
210 220 230 240 250
MIIIPETPRW FVNRGQEERA RKALKWLRGK EADVEPELKD LMQSQAEADS
260 270 280 290 300
QARRNTCLEL FKRINLKPLS ISLGLMFFQQ FSGINAVIFY TVQIFKDAGS
310 320 330 340 350
TIDSNLCTII VGIVNFFATF MGILLIDRLG RKILLYISDI AMILTLSILG
360 370 380 390 400
GFFYCKAHGP DVSHLGWLPL TCFVIYILGF SLGFGPIPWL MMGEILPAKI
410 420 430 440 450
RGPAASVVTA FNWFCTFVVT KTFQDLTVAM GAHGAFWLFG VVCIVGLFFV
460 470 480
IICVPETRGK SLEEIERKMM GRVPISAVVN IKPFSFNM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000362 Genomic DNA Translation: EDX06650.1 |
RefSeqi | XP_002081065.1, XM_002081029.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0210718; FBpp0209210; FBgn0182571 |
GeneIDi | 6734029 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000362 Genomic DNA Translation: EDX06650.1 |
RefSeqi | XP_002081065.1, XM_002081029.2 |
3D structure databases
SMRi | B4QBN3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7240.B4QBN3 |
Proteomic databases
PRIDEi | B4QBN3 |
Genome annotation databases
EnsemblMetazoai | FBtr0210718; FBpp0209210; FBgn0182571 |
GeneIDi | 6734029 |
Phylogenomic databases
HOGENOMi | CLU_001265_30_5_1 |
OMAi | VFQRLIM |
PhylomeDBi | B4QBN3 |
Gene expression databases
Bgeei | FBgn0182571, Expressed in adult organism and 4 other tissues |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRE12_DROSI | |
Accessioni | B4QBN3Primary (citable) accession number: B4QBN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 23, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families