UniProtKB - B4Q354 (EIF3I_DROSI)
Protein
Eukaryotic translation initiation factor 3 subunit I
Gene
eIF3i
Organism
Drosophila simulans (Fruit fly)
Status
Functioni
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation
GO - Molecular functioni
- translation initiation factor activity Source: UniProtKB-UniRule
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit IUniRule annotationShort name: eIF3iUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 2UniRule annotation TRIP-1 homolog |
Gene namesi | Name:eIF3iUniRule annotation Synonyms:eif3-S2UniRule annotation, Trip1UniRule annotation ORF Names:GD22675Imported |
Organismi | Drosophila simulans (Fruit fly) |
Taxonomic identifieri | 7240 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0194072, Dsim\GD22675 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- eukaryotic 43S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: UniProtKB-UniRule
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000365349 | 1 – 326 | Eukaryotic translation initiation factor 3 subunit IAdd BLAST | 326 |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 47 | WD 1Add BLAST | 40 | |
Repeati | 50 – 89 | WD 2Add BLAST | 40 | |
Repeati | 145 – 184 | WD 3Add BLAST | 40 | |
Repeati | 188 – 227 | WD 4Add BLAST | 40 | |
Repeati | 285 – 326 | WD 5Add BLAST | 42 |
Sequence similaritiesi
Belongs to the eIF-3 subunit I family.UniRule annotation
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
HOGENOMi | CLU_043845_0_1_1 |
OMAi | VWFSHNG |
PhylomeDBi | B4Q354 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03008, eIF3i, 1 hit |
InterProi | View protein in InterPro IPR027525, eIF3i IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 2 hits |
i Sequence
Sequence statusi: Complete.
B4Q354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPLMLQGHE RSITQIKYNR EGDLLFSCSK DQKPNVWYSL NGERLGTYDG
60 70 80 90 100
HQGAVWCLDV DWESRKLITG AGDMTAKIWD VEYGTVIASI PTKSSVRTSN
110 120 130 140 150
FSFSGNQAAY STDKAMGQSC ELFLIDVRNA DSSLSEQEPT LRIPMTESKI
160 170 180 190 200
TSMLWGPLDE TIITGHDNGN IAIWDIRKGQ KVVDSGTDHS AGINDMQLSK
210 220 230 240 250
DGTMFVTASR DTTAKLFDSE SLMCLKTYKT ERPVNSAAIS PIMDHVVLGG
260 270 280 290 300
GQDAMEVTTT STKAGKFDSR FFHLIYEEEF ARLKGHFGPI NSLAFHPDGK
310 320
SYASGGEDGF VRVQTFDSTY FENIFE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000361 Genomic DNA Translation: EDX03770.1 |
RefSeqi | XP_002078185.1, XM_002078149.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0222585; FBpp0221077; FBgn0194072 |
GeneIDi | 6731024 |
KEGGi | dsi:Dsimw501_GD22675 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000361 Genomic DNA Translation: EDX03770.1 |
RefSeqi | XP_002078185.1, XM_002078149.2 |
3D structure databases
SMRi | B4Q354 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0222585; FBpp0221077; FBgn0194072 |
GeneIDi | 6731024 |
KEGGi | dsi:Dsimw501_GD22675 |
Organism-specific databases
FlyBasei | FBgn0194072, Dsim\GD22675 |
Phylogenomic databases
HOGENOMi | CLU_043845_0_1_1 |
OMAi | VWFSHNG |
PhylomeDBi | B4Q354 |
Miscellaneous databases
ChiTaRSi | Trip1, fly |
Gene expression databases
Bgeei | FBgn0194072, Expressed in embryo and 4 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03008, eIF3i, 1 hit |
InterProi | View protein in InterPro IPR027525, eIF3i IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EIF3I_DROSI | |
Accessioni | B4Q354Primary (citable) accession number: B4Q354 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families