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Entry version 88 (02 Jun 2021)
Sequence version 2 (20 Jan 2016)
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Protein

Sema domain-containing protein

Gene

Dyak\GE14532

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation
Biological processDifferentiationARBA annotation, NeurogenesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sema domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dyak\GE14532Imported
ORF Names:Dyak_GE14532Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila yakuba (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7245 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002282 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 45HelicalSequence analysisAdd BLAST20
Transmembranei1399 – 1421HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0232132, Expressed in adult organism and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7245.FBpp0259542

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4PVX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 553SemaInterPro annotationAdd BLAST473

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1425 – 1445Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001436_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMQIKPL

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625, PTHR22625, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 3 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4PVX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELMPKRNYK QLQYTKTKII MLRNEFYCAN LIHVLHGLCI ITIIGSQHYS
60 70 80 90 100
VSCFEELPAQ VMSPLNDIVA QFNLPSIPAQ STESPYGNRS IGNQVENVGD
110 120 130 140 150
SQSKNYFTHL SFDFMHNVIF AGATNKILKL NENLRVLAEA VTGPVHDSPQ
160 170 180 190 200
CHAGGCPEEI ETSLVNNFNK ILVVSYAHDG ILIACGSIRQ GACEIYSLPR
210 220 230 240 250
FPAPPEFFAV PLAANDENAS TYAFVGPSRY TWKEEDILYV GTTFTNVGDY
260 270 280 290 300
RHDVPAISSR RLDDLNYAEF SIQQSIINID VKYRDHFLVD YLYGFNSSEY
310 320 330 340 350
AYFIIVQKKS HLADEAGYVT RLARICITDP NYDSYTEITI QCTATENNVD
360 370 380 390 400
YNILRDAKIT TASHKLAQKM GIKKDDHVLI TVFSPSKEIS NQPESKSAMC
410 420 430 440 450
IYSIKDIEDM FIENIHLCFN GTIKDRNLGY ISGTINDGRC PIVGSLGNIY
460 470 480 490 500
NFCSVGLKIS GVSPITAHAL FHFENVSVTS VTATSTTDQQ HSLAFLGTSK
510 520 530 540 550
GVIKKVLLSG QSPGEYEEIV VDAGNRILPN TMMSPKKDFL YVLSQRKITK
560 570 580 590 600
LRIEHCSVYT NCSACLESRD PFCGWCSLER RCTVRSTCQR DTSASRWLSL
610 620 630 640 650
GSGQQCIEFE SIIPDKIPIS ELTHLHLIIR TLPEPFNAKY RCVFGNSTPI
660 670 680 690 700
DAEILENGLG CATPPLNERP LIPTNTDHIL VPLSVRSSET NKDFVSRYFA
710 720 730 740 750
FFDCSHHGKC QECLQSSWGC NWCIFDNKCV HKSLQCRNIE NSVSTLGHCP
760 770 780 790 800
HLKKNRPEIL IPVRVPIEIR LEIENLPKPK STHAGFLCTI HIEAAQMLLP
810 820 830 840 850
AHVESNKIVV CEKTPYFYET NAHEYQAKVV VTWNFQHYVD TAIVTLYKCD
860 870 880 890 900
VLGSHREHAD CSLCVTRDPK YKCAWCSNSC VYNETCIANR ISSSSGSEAA
910 920 930 940 950
IENECPLPRI DIIKPLSGPV EGGTLITIEG SNLGIREEDV RGKIFIGSVP
960 970 980 990 1000
CELENYQISV KIECRTGAAL YEMSAPIKVA NDAGYTESSV QFHFKNVLLT
1010 1020 1030 1040 1050
GLYPTIGPRS GGTQLSLIGK FLNIGSTMRA FLDEYECHID VTQASSSQVS
1060 1070 1080 1090 1100
CTTSEATQPE PIRSLHLVID GANRTLECHL SAPSITNTNP NRSNFGSYQL
1110 1120 1130 1140 1150
RTPPRQPCSI FNYTQDPRIM QIKPLRSFVS GGRVLTVHGI YLNSIQKPEL
1160 1170 1180 1190 1200
EVFYDNERVN KTSCVVINSN QMECPSPPVN YKFETFKKTN RVPDTELHLQ
1210 1220 1230 1240 1250
NLSSPTESRF KNEYDRKKRL TDFGDNFRIY TTGGTSASYF VNNNMDVTTF
1260 1270 1280 1290 1300
VKVHETQLNL QISFVMDNVQ LVRNLNKYFH DIRSTIVYLA DPKYLAFPND
1310 1320 1330 1340 1350
GVKLYKGDSL VIEGELLNLA ADEYDVNVTI GTSQCNITSL ALTQLLCIPP
1360 1370 1380 1390 1400
EQQPLPTDEN GVDQSTDLPL VVVKVGRNLR FVIGYLKYDL NKPYVFSHAL
1410 1420 1430 1440 1450
FVVILTVALL VIVFVTVLII FRRKSTQAER EYKRIQIQMI TLESNVRSEC
1460 1470 1480 1490 1500
KQAFAELQTD MTDLTADLES TGIPTLDHVN YIMKVFFPGV SDHPILNSPK
1510 1520 1530 1540 1550
FRGGVPQTNY DAAMIQFEQL IGNKYFLLMF IETLEAQRSS FSIRDRVNVA
1560 1570 1580 1590 1600
SLLMVVLMNK MEYATEILKS LLLRLIDKSL TSKHPQLMLR RTESVVEKML
1610 1620 1630 1640 1650
TNYLAICMYD YLKEYAGSNL FLLFKAIKHQ IEKGLVDAIT NDARYSLSEE
1660 1670 1680 1690 1700
RLLHEQVTHS VVILHILQDD LDEKVQCRVN DWDTISQVKL KILDAIFKNT
1710 1720 1730 1740 1750
PFSMRPSVHE VDLEWRHGRG GHLTLQDEDL TTKTVNGWKR LNTLAHYGVK
1760 1770 1780 1790 1800
ESAVMSLIAR QNDNYHIPYS KNQNSAPYHN FYFINNSQSH IIINNDIESG
1810 1820 1830 1840 1850
LQQPRLYHLV KPNIPDHYMN IKNSVLSGGS PAFQSSHVVS NCIDRVNKTI
1860 1870 1880 1890 1900
PEVYLTRLLA TKGTIQKFVD DFFSIILTVN EELPPAVKWL FDLLDEAARR
1910 1920 1930 1940 1950
HDIADTEIVH AWKSNCLPLR FWVNFIKNPD FIFDVNKTYS VDSCLSVIAQ
1960 1970 1980 1990 2000
TFMDACSTSE HRLGKDSPSN KLLFAKDIPN YRIMVKEFYR DVSKLPQISD
2010 2020 2030 2040 2050
QEMSTAMQQL SVRQNEEFDT ISALKELYIY ITKYKDQIME SLETDINCRK
2060 2070
MHLSRKLGNV AAILDGDCTS NC
Length:2,072
Mass (Da):234,160
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71E53B80CCD1C2CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM000161 Genomic DNA Translation: EDW99282.2

NCBI Reference Sequences

More...
RefSeqi
XP_002099570.2, XM_002099534.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0261050; FBpp0259542; FBgn0232132

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6523698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dya:Dyak_GE14532

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000161 Genomic DNA Translation: EDW99282.2
RefSeqiXP_002099570.2, XM_002099534.2

3D structure databases

SMRiB4PVX7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0259542

Genome annotation databases

EnsemblMetazoaiFBtr0261050; FBpp0259542; FBgn0232132
GeneIDi6523698
KEGGidya:Dyak_GE14532

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
HOGENOMiCLU_001436_2_0_1
OMAiIMQIKPL
OrthoDBi90434at2759

Gene expression databases

BgeeiFBgn0232132, Expressed in adult organism and 1 other tissue

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 3 hits
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 3 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4PVX7_DROYA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4PVX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: June 2, 2021
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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