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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Dyak\GE20163

Organism
Drosophila yakuba (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dyak\GE13850), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dyak\GE17763), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dyak\GE20163), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dyak\GE19076)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dyak\GE20163Imported
ORF Names:Dyak_GE20163Imported, GE20163Imported
OrganismiDrosophila yakuba (Fruit fly)Imported
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0237485 Dyak\GE20163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Expressioni

Gene expression databases

BgeeiFBgn0237485

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0265173

Structurei

3D structure databases

ProteinModelPortaliB4PFS4
SMRiB4PFS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 445FAD_binding_2InterPro annotationAdd BLAST398
Domaini500 – 651Succ_DH_flav_CInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
KOiK00234
OMAiAGHTCTG
OrthoDBiEOG091G041Z
PhylomeDBiB4PFS4

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

B4PFS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLFVRRAG QHVTRTLLGP SASRLPQVTA VRDASCKDEY SLVDHKFDAI
60 70 80 90 100
VIGAGGAGMR AGFGLAEKGF QTAIISKLFP TRSHTVAAQG GVNAALSNMD
110 120 130 140 150
KDDWKYHFYD TVKGSDWLGD QNAIHYMCRE AEKAVCELDM YGMPFSRKPD
160 170 180 190 200
GKIYQRPFGG QTLDYGKGGV ARRACACADR TGHALIHTLY GQTLKHSDFC
210 220 230 240 250
HYFVDYFVLD LIMSQGACVG CLAWKLDDGT FHRFLAKNTV VAAGGCGRVY
260 270 280 290 300
FSTTAGHTCT GDGNAWVSRQ ELPLMDMEFV QFHPTGIYGA GCLITEGVRG
310 320 330 340 350
EGGFFLNCKG ERFMERYAPK AKDLASRDVV ARAMTMEVLA GNGCGPLKDH
360 370 380 390 400
VHLQLHHIDA KIIKQRLPGI MVTARIFAKV DVTKEPVPVL PTVHYNMGGI
410 420 430 440 450
PTDYKGRVVT IDENGKEQIV KGLYSCGETS CASVHGANRL GANSLLDLII
460 470 480 490 500
FGRVCALDIA ANSCPGDKPP QVEDKATEKS LDNFKRLRCA DGCIPTATLR
510 520 530 540 550
MELQRTMTKH AAVFREGKLL KEGLLKVAEL CKQFKDIKIT DRTLVWNTNL
560 570 580 590 600
VETLELQNML ANAVHIITAM ENRKESRGSH AREDFQKRVD ELDYGAPLAG
610 620 630 640 650
QKKKPIEEHW RKHTMTFALG NMGCASIKYR PVVDTTLDSS VAPIPPAPRT

Y
Length:651
Mass (Da):71,718
Last modified:September 23, 2008 - v1
Checksum:i7F2B36B8751AA154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000159 Genomic DNA Translation: EDW94223.1
RefSeqiXP_002094511.1, XM_002094475.2

Genome annotation databases

EnsemblMetazoaiFBtr0266681; FBpp0265173; FBgn0237485
GeneIDi6533810
KEGGidya:Dyak_GE20163

Similar proteinsi

Entry informationi

Entry nameiB4PFS4_DROYA
AccessioniPrimary (citable) accession number: B4PFS4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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