Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 62 (23 Feb 2022)
Sequence version 1 (23 Sep 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Facilitated trehalose transporter Tret1

Gene

Tret1

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Facilitated trehalose transporter Tret1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tret1By similarity
ORF Names:GK22112
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila willistoni (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7260 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 406CytoplasmicSequence analysisAdd BLAST406
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei407 – 427Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini428 – 454ExtracellularSequence analysisAdd BLAST27
Transmembranei455 – 475Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini476 – 488CytoplasmicSequence analysisAdd BLAST13
Transmembranei489 – 509Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini510 – 511ExtracellularSequence analysis2
Transmembranei512 – 532Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini533 – 538CytoplasmicSequence analysis6
Transmembranei539 – 559Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini560 – 566ExtracellularSequence analysis7
Transmembranei567 – 587Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini588 – 650CytoplasmicSequence analysisAdd BLAST63
Transmembranei651 – 671Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini672 – 687ExtracellularSequence analysisAdd BLAST16
Transmembranei688 – 708Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini709 – 714CytoplasmicSequence analysis6
Transmembranei715 – 735Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini736 – 755ExtracellularSequence analysisAdd BLAST20
Transmembranei756 – 776Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini777 – 784CytoplasmicSequence analysis8
Transmembranei785 – 803Helical; Name=11Sequence analysisAdd BLAST19
Topological domaini804 – 816ExtracellularSequence analysisAdd BLAST13
Transmembranei817 – 837Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini838 – 872CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003955491 – 872Facilitated trehalose transporter Tret1Add BLAST872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineBy similarity1
Modified residuei263PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei336PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei860PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7260.FBpp0251255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4MYA4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni53 – 217DisorderedSequence analysisAdd BLAST165
Regioni262 – 281DisorderedSequence analysisAdd BLAST20
Regioni293 – 315DisorderedSequence analysisAdd BLAST23
Regioni340 – 361DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 68Polar residuesSequence analysisAdd BLAST16
Compositional biasi82 – 101Polar residuesSequence analysisAdd BLAST20
Compositional biasi103 – 117Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi119 – 144Polar residuesSequence analysisAdd BLAST26
Compositional biasi170 – 192Polar residuesSequence analysisAdd BLAST23
Compositional biasi193 – 208Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi297 – 315Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysisBy similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0254, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016710_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4MYA4

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFIWTQS

Database of Orthologous Groups

More...
OrthoDBi
430696at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4MYA4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd17358, MFS_GLUT6_8_Class3_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846, MFS_dom
IPR044775, MFS_ERD6/Tret1-like
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083, Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171, SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879, SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits
PS00217, SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4MYA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRDNRGAG GGGGGGGGGS GGGHHHHQPL SSAMGKLKEK LTRVGDDLGY
60 70 80 90 100
HRVESNLSTS NTATSLDTIL PEDPFLFPQE APQRHPQQSP SQSQQQQRRF
110 120 130 140 150
LDDEPPLSFR PLLEDDDINE PPTQQQPQQQ HQQQHRSPLS ASGSLELTPL
160 170 180 190 200
PPPPTTLEPR DRQQRSIPGE DLQRSKQSLK GSRVSFEKTN SKQAAESSDE
210 220 230 240 250
DSFEDKRIGF QQQKATSVDH KGILKDLKHI LANDNRRQFQ AKKHVSLDVK
260 270 280 290 300
GTRFLQDLLK ESSSEEEFHK TRREFQGRKH QSLDPRVTFK LDKVLQGSST
310 320 330 340 350
DSDEEGDDAE HKRLIHRPKD ITKPVIIDLK DLESESDEDF LTSRQHFQQQ
360 370 380 390 400
RSISTDSRKS RRLYEMDDMG NKRGDNIRHA VPFVRQITED GKPKLEVYRP
410 420 430 440 450
TTNPIYIWTQ VLAALSVSLG SLVVGFVSAY TSPALITMTN GNITSFEVTP
460 470 480 490 500
QAASWVGGIM PLAGLLGGIA GGPFIEYLGR RNTILTTAVP FIVSSLLIAC
510 520 530 540 550
AVNITMVLLG RFLAGFCVGI ASLSLPVYLG ETVQPEVRGT LGLLPTAFGN
560 570 580 590 600
IGILLCFVAG TYMDWSMLAF LGAALPVPFL ILMFLIPETP RWYVSRGREE
610 620 630 640 650
RARKALSWLR GKEADVEPEL KGLLRSQADA DRSATQNTML ELLKRNNLKP
660 670 680 690 700
LSISLGLMFF QQLSGINAVI FYTVQIFKDA GSTIDGNVCT IIVGIVNFMA
710 720 730 740 750
TFIGIILIDR AGRKILLYVS NVAMIITLFV LGGFFYCKDK AGIDVSNVGW
760 770 780 790 800
LPLSCFVVYI LGFSLGFGPI PWLMMGEILP AKIRGSAASV ATAFNWTCTF
810 820 830 840 850
VVTKTFQDML DVIGSYGAFW LFGAICFIGL FFVIIYVPET QGKTLEDIER
860 870
KMMGRVRRMS SVANIKPLSF NM
Length:872
Mass (Da):96,531
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AA1ABE731333DA9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH963894 Genomic DNA Translation: EDW77093.1

NCBI Reference Sequences

More...
RefSeqi
XP_002066107.1, XM_002066071.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0252763; FBpp0251255; FBgn0224097

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6643376

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dwi:6643376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH963894 Genomic DNA Translation: EDW77093.1
RefSeqiXP_002066107.1, XM_002066071.2

3D structure databases

SMRiB4MYA4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7260.FBpp0251255

Genome annotation databases

EnsemblMetazoaiFBtr0252763; FBpp0251255; FBgn0224097
GeneIDi6643376
KEGGidwi:6643376

Phylogenomic databases

eggNOGiKOG0254, Eukaryota
HOGENOMiCLU_016710_0_0_1
InParanoidiB4MYA4
OMAiIFIWTQS
OrthoDBi430696at2759
PhylomeDBiB4MYA4

Family and domain databases

CDDicd17358, MFS_GLUT6_8_Class3_like, 1 hit
Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR020846, MFS_dom
IPR044775, MFS_ERD6/Tret1-like
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 1 hit
PRINTSiPR00171, SUGRTRNSPORT
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00879, SP, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits
PS00217, SUGAR_TRANSPORT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRET1_DROWI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4MYA4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: February 23, 2022
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again