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Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog
Alternative name(s):
MANF/CDNF-like protein
Gene namesi
Name:ManfBy similarity
ORF Names:GJ23764
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0210861 Dvir\GJ23764

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039094623 – 173Mesencephalic astrocyte-derived neurotrophic factor homologAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 114By similarity
Disulfide bondi31 ↔ 103By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi148 ↔ 151By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiB4LX78

Expressioni

Gene expression databases

BgeeiFBgn0210861

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0238181

Structurei

3D structure databases

SMRiB4LX78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4154 Eukaryota
ENOG4111QMZ LUCA
InParanoidiB4LX78
KOiK22556
OMAiNRFCYYL
OrthoDBiEOG091G0P3O
PhylomeDBiB4LX78

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR019345 Armet_prot
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR12990 PTHR12990, 1 hit
PfamiView protein in Pfam
PF10208 Armet, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4LX78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHIVLMI CFIVGVGQTA LALKEDDCEV CVKTVKRFAD TLDDATKKDY
60 70 80 90 100
KLIETAFKKY CKTQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE
110 120 130 140 150
KVCEKLKKKD AQICDLRYEK QIDLNSVDLK KLKVRDLKKI LNDWDESCDG
160 170
CLEKSDFIKR IEELKPKYSR NEL
Length:173
Mass (Da):20,041
Last modified:September 23, 2008 - v1
Checksum:i7540A6DD06A62933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA Translation: EDW66730.1
RefSeqiXP_002053210.1, XM_002053174.2

Genome annotation databases

EnsemblMetazoaiFBtr0239689; FBpp0238181; FBgn0210861
GeneIDi6630749
KEGGidvi:Dvir_GJ23764

Similar proteinsi

Entry informationi

Entry nameiARMET_DROVI
AccessioniPrimary (citable) accession number: B4LX78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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