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UniProtKB - B4LPX5 (TRET1_DROVI)
Protein
Facilitated trehalose transporter Tret1
Gene
Tret1
Organism
Drosophila virilis (Fruit fly)
Status
Functioni
Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
By similarityGO - Molecular functioni
- sugar transmembrane transporter activity Source: InterPro
- trehalose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- trehalose transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Facilitated trehalose transporter Tret1By similarity |
Gene namesi | Name:Tret1By similarity ORF Names:GJ20366 |
Organismi | Drosophila virilis (Fruit fly) |
Taxonomic identifieri | 7244 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 446 | CytoplasmicSequence analysisAdd BLAST | 446 | |
Transmembranei | 447 – 467 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 468 – 494 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 495 – 515 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 516 – 527 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 528 – 548 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 549 – 551 | ExtracellularSequence analysis | 3 | |
Transmembranei | 552 – 572 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 573 – 578 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 579 – 599 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 600 – 606 | ExtracellularSequence analysis | 7 | |
Transmembranei | 607 – 627 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 628 – 690 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 691 – 711 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 712 – 727 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 728 – 748 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 749 – 754 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 755 – 775 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 776 – 794 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 795 – 815 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 816 – 821 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 822 – 842 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 843 – 855 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 856 – 876 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 877 – 911 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395548 | 1 – 911 | Facilitated trehalose transporter Tret1Add BLAST | 911 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 303 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 374 | PhosphoserineBy similarity | 1 | |
Modified residuei | 376 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 482 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 899 | PhosphoserineBy similarity | 1 | |
Modified residuei | 900 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 256 | DisorderedSequence analysisAdd BLAST | 256 | |
Regioni | 334 – 355 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 380 – 402 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 64 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 78 – 129 | Polar residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 155 – 172 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 202 – 216 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 229 – 248 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 337 – 355 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysisBy similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
InParanoidi | B4LPX5 |
OrthoDBi | 430696at2759 |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B4LPX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRDNRGAG GGGGGGGGGG HHHQPLSSAM GKLKEKLTRA GEELGYHRVE
60 70 80 90 100
SNLSTSNTGT SLDTILPEDP FPFPQAAPQR HPQQQFPHLQ SPQQQRQQLQ
110 120 130 140 150
QQQLQQQQLH LQQPQQQLQQ QQQPQQQLRL LHDVDDEPPL SFRPLLEDVD
160 170 180 190 200
INEPPQQIHV QQQQQQLPRT ALRASGSLEL TPLPPPPTSL EPHRDRQQRS
210 220 230 240 250
IVTGGEELQR SKQSLKGSRV SFEKPRGEQL PAKAAESSDE DSFEDKRIGF
260 270 280 290 300
QQQKATSVDH KGILKDLKHI LANDNRRQFQ AKKHVSLDIK GTRFLKDLLK
310 320 330 340 350
DSSSEEEFHK TRREFQGRKH QSLDPRVTFK LDKVLQGSST DSDEEGDDAE
360 370 380 390 400
HKRLIHRPKD ITKPVIIDLK DLESESDEDF LTSRQNFQQQ RSISTDSRKS
410 420 430 440 450
RRLYEMDEMG NKRGDNIRHA VPFVRQITED GKPKLEVYRP TTNPIYIWTQ
460 470 480 490 500
VLAALSVSLG SLVVGFASAY TSPALVSMTN TNLTSFVVTP QAASWVGGIM
510 520 530 540 550
PLAGLAGGIA GGPFIEYLGR RNTILATAVP FIVSWLLIAC AVNVIMVLCG
560 570 580 590 600
RFLAGFCVGI ASLSLPVYLG ETVQPEVRGT LGLLPTAFGN IGILLCFVAG
610 620 630 640 650
TYMDWSMLAF LGASLPVPFL ILMFLIPETP RWYVSRGREE RARKALVWLR
660 670 680 690 700
GKEADVEPEL KGLMRSQADA DRQATQNKML ELLKRSNLKP LSISLGLMFF
710 720 730 740 750
QQLSGINAVI FYTVQIFQDA GSTIDGNVCT IIVGVVNFAA TFIATILIDR
760 770 780 790 800
AGRKVLLYVS NVMMVLTLFV LGGFFYCKSS GMDTSNVGWL PLSCFVIYIL
810 820 830 840 850
GFSLGFGPIP WLMMGEILPA KIRGSAASVA TAFNWSCTFV VTKSFQDMID
860 870 880 890 900
FMGAHGAFWM FGAICFIGLF FVIFYVPETQ GKTLEDIERK MMGRVRRMSS
910
VANIKPLSFN M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0Q9WFV5 | A0A0Q9WFV5_DROVI | Uncharacterized protein, isoform C | Dvir\GJ20366 Dvir_GJ20366 | 489 | Annotation score: |
Sequence cautioni
The sequence EDW61315 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH940648 Genomic DNA Translation: EDW61315.1 Sequence problems. |
RefSeqi | XP_002050122.2, XM_002050086.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0435437; FBpp0392404; FBgn0207506 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH940648 Genomic DNA Translation: EDW61315.1 Sequence problems. |
RefSeqi | XP_002050122.2, XM_002050086.2 |
3D structure databases
SMRi | B4LPX5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7244.FBpp0234783 |
Genome annotation databases
EnsemblMetazoai | FBtr0435437; FBpp0392404; FBgn0207506 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
InParanoidi | B4LPX5 |
OrthoDBi | 430696at2759 |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRET1_DROVI | |
Accessioni | B4LPX5Primary (citable) accession number: B4LPX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | February 23, 2022 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families