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Entry version 85 (05 Jun 2019)
Sequence version 2 (20 Jan 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

Dvir\GJ21322

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dvir\GJ21322Imported
ORF Names:Dvir_GJ21322Imported, GJ21322Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila virilis (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7244 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008792 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0208453 Dvir\GJ21322

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0208453 Expressed in 1 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7244.FBpp0235739

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4LNR6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 347ANK_REP_REGIONInterPro annotationAdd BLAST188
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati194 – 226ANKPROSITE-ProRule annotationAdd BLAST33
Repeati261 – 293ANKPROSITE-ProRule annotationAdd BLAST33
Repeati294 – 326ANKPROSITE-ProRule annotationAdd BLAST33
Domaini532 – 593SH3InterPro annotationAdd BLAST62
Domaini701 – 794PDZInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni426 – 522DisorderedSequence analysisAdd BLAST97
Regioni606 – 683DisorderedSequence analysisAdd BLAST78
Regioni806 – 932DisorderedSequence analysisAdd BLAST127
Regioni968 – 992DisorderedSequence analysisAdd BLAST25
Regioni1004 – 1026DisorderedSequence analysisAdd BLAST23
Regioni1085 – 1116DisorderedSequence analysisAdd BLAST32
Regioni1184 – 1319DisorderedSequence analysisAdd BLAST136
Regioni1332 – 1457DisorderedSequence analysisAdd BLAST126
Regioni1603 – 1657DisorderedSequence analysisAdd BLAST55
Regioni1671 – 1697DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1129 – 1149Sequence analysisAdd BLAST21
Coiled coili1767 – 1812Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi426 – 442PolarSequence analysisAdd BLAST17
Compositional biasi503 – 522PolarSequence analysisAdd BLAST20
Compositional biasi806 – 832PolarSequence analysisAdd BLAST27
Compositional biasi902 – 932PolarSequence analysisAdd BLAST31
Compositional biasi1192 – 1225PolarSequence analysisAdd BLAST34
Compositional biasi1232 – 1250PolarSequence analysisAdd BLAST19
Compositional biasi1253 – 1269Pro-richSequence analysisAdd BLAST17
Compositional biasi1271 – 1287PolarSequence analysisAdd BLAST17
Compositional biasi1334 – 1401PolarSequence analysisAdd BLAST68
Compositional biasi1408 – 1422PolarSequence analysisAdd BLAST15
Compositional biasi1679 – 1697PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG3528 Eukaryota
COG0666 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4LNR6

KEGG Orthology (KO)

More...
KOi
K15009

Database of Orthologous Groups

More...
OrthoDBi
468249at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032425 FERM_f0
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF16511 FERM_f0, 1 hit
PF17820 PDZ_6, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4LNR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTSGPGAF DDEPPPEPRD GWLLVRIHVP ELNVYKCLQF PSERLVWDVK
60 70 80 90 100
QQVLASLPKE LKESFNYGLF APPSNGKAGK FLDEERRLGD YPFNGPVGYL
110 120 130 140 150
ELKYKRRVYK MLTLDERQLK ALHTRANLRR FLECINGGHV EKIAKMCAKG
160 170 180 190 200
LDPNFHCSES GETPLSVATG AKKPNKLLIA LVNGGALLDY RTKDGTTALH
210 220 230 240 250
RAVEHDSLEA VSTLLELGAS PNYRDGRGIT PLYISITRKC EAKITESLLH
260 270 280 290 300
DHATLGIQDS QGWNEVHQAC RHGLVQHLEH LLFYGADMDG RNASGNSPLH
310 320 330 340 350
VCAVNNQEAC ARMLLFRGAQ RGAQNFANQT PYQVAVIAGN LELAEIIENY
360 370 380 390 400
KSEDIVPFRG PPRYNPKRRS GIGWLSANGA AGAGLLAAAA GGLDGAGGAG
410 420 430 440 450
AGPGGGMCVN GNGGGSLMGT LSRQQLQQLQ PHQTQNQPHN HNQHVQHLHH
460 470 480 490 500
QHQHQQPHLQ LHGPPSPCPS EHMLGAYSSA SSSLSEGSSG HRSHEDDISI
510 520 530 540 550
VTDKSLGDTS DIISDSSGVG TNSDSAACSI GHPSTTVVCM EPYAGNTVGH
560 570 580 590 600
IRLQPGDVIE VVGSTDCGLL EGYVRGTNQS GFFPADCVQE VNLRQKHITN
610 620 630 640 650
VMTASTGMAA PQQQQPLQPQ PASYQGSPQL SLGGHSGSSS TLLHQPHQSP
660 670 680 690 700
SLSMTSNGSC QQQQQHLAEG NGGHMGNNSI GQYSSATAPR IKKGAYNAPR
710 720 730 740 750
SVVLHRAKRG FGFILRGAKA SSQLMQLRPS ERFPALQYLD DVDPGGVADM
760 770 780 790 800
AGLRPGDFLL TINGEDVSAA SHEQVVEMIR SAGALVNMTV VSPQFPLQMQ
810 820 830 840 850
ASAQYLPSGA RAGSQHLNSG PSTPQSAHRQ CATLPRKMSM GPGSHASGSS
860 870 880 890 900
ASGGGGSVRM APMPPRRDPK TTLSVGRARA KSMVAGLENG GEKEQDEVPH
910 920 930 940 950
TKSNSVESIA TPTPTHPGTP VQLRTASIKA RPTSSRITAA ELEELFQRQQ
960 970 980 990 1000
GEGSASSASR YATMMTSSRF QSGTDSGAAT PPAANGSPMR TGPLVYGSVA
1010 1020 1030 1040 1050
EMKRKTARSK HGNGTLRGKP VATPTVGGAI VGSGRDLKRF HSTPDLHGPQ
1060 1070 1080 1090 1100
LHGSASSIWQ AAGKGHHSQD DVATLHASLQ RLNTAGHKEE SKAAAAAAAA
1110 1120 1130 1140 1150
GGAVLPPPNH PPPPPPVGQV VKVETRSSVS EYESTISLQQ KLKKRAENDA
1160 1170 1180 1190 1200
VTSAAIDGVQ SSFNPSANAK IYASPQELRN VMAWKLRQAQ EKPQQEAASQ
1210 1220 1230 1240 1250
QQQQQPQQQH VSQYAAPTQL RAQAPASAGS HYAAPQLQQP QPTTAQAAAA
1260 1270 1280 1290 1300
AAPQSPPAPP PPAPQPPPAA AAAQEQQQAN GNATATVAGA TAGAAPPIPE
1310 1320 1330 1340 1350
PDYSCSESDG EDENSILVAR NTKLNEKIAL FDVPETSGNS QASGSSSASG
1360 1370 1380 1390 1400
SGASISHSLS VEEIQRIRSN LKTSKSSPNG FLKKEDEQQQ QQAQQPQQLL
1410 1420 1430 1440 1450
PQPAAGEDEC DNSSSGVSSD QELLATGVGK PTDTIKKKPS VTIVEEPKTI
1460 1470 1480 1490 1500
PDPPAKPLAK TTISIGAATA TATATATVKQ LVQQQHAPVI QQQQQQLSSK
1510 1520 1530 1540 1550
PATTVANKLP ATAATAQIKS NQPVLSPQVL GRIPNVHHQQ QLQQQQQQQQ
1560 1570 1580 1590 1600
LHHQSNPNLK LIATQQQILQ QQQQQLAHQQ HLQQILKAKA AAAGGASTAA
1610 1620 1630 1640 1650
LVAKQQQQLH KSHDSELEQR SDLDDDDGEL SPSPPAKAFQ RHNSLTRKQA
1660 1670 1680 1690 1700
AAIAMQRGAT RTTAVSLVQL PPPLEADSDG EPTQQQHLQH HQQQQQQQQM
1710 1720 1730 1740 1750
ATHIVGMLPS GQLVAVPSAA VAAAAAVPQP GNNNLQLCTE NLVLAPPPQF
1760 1770 1780 1790 1800
CDCNDAKHTP QYHPQQQQQQ QQHLQQQQQQ LLQQQQRHQQ QLQLLQQQHQ
1810 1820 1830 1840
QQQQQQQQQQ QQQQHQRLSG GAGAGAVGTL GRVRIVGAMP KANHHRLH
Length:1,848
Mass (Da):196,697
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i300C247D7113E0DF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH940648 Genomic DNA Translation: EDW60136.2

NCBI Reference Sequences

More...
RefSeqi
XP_002048943.2, XM_002048907.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0433744; FBpp0390860; FBgn0208453

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6626329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dvi:Dvir_GJ21322

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940648 Genomic DNA Translation: EDW60136.2
RefSeqiXP_002048943.2, XM_002048907.2

3D structure databases

SMRiB4LNR6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0235739

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0433744; FBpp0390860; FBgn0208453
GeneIDi6626329
KEGGidvi:Dvir_GJ21322

Organism-specific databases

FlyBaseiFBgn0208453 Dvir\GJ21322

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG3528 Eukaryota
COG0666 LUCA
InParanoidiB4LNR6
KOiK15009
OrthoDBi468249at2759

Gene expression databases

BgeeiFBgn0208453 Expressed in 1 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032425 FERM_f0
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16511 FERM_f0, 1 hit
PF17820 PDZ_6, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4LNR6_DROVI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4LNR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: June 5, 2019
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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