Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 90 (29 Sep 2021)
Sequence version 1 (23 Sep 2008)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein, isoform A

Gene

Dvir\GJ21297

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein, isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dvir\GJ21297Imported
ORF Names:Dvir_GJ21297Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila virilis (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7244 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008792 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4460 – 4480HelicalSequence analysisAdd BLAST21
Transmembranei4652 – 4670HelicalSequence analysisAdd BLAST19
Transmembranei4736 – 4758HelicalSequence analysisAdd BLAST23
Transmembranei4925 – 4947HelicalSequence analysisAdd BLAST23
Transmembranei5001 – 5024HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0208429, Expressed in adult organism and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7244.FBpp0235714

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 148MIRInterPro annotationAdd BLAST55
Domaini577 – 803B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1032 – 1217B30.2/SPRYInterPro annotationAdd BLAST186
Domaini1452 – 1673B30.2/SPRYInterPro annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1417 – 1516DisorderedSequence analysisAdd BLAST100
Regioni2286 – 2306DisorderedSequence analysisAdd BLAST21
Regioni3596 – 3615DisorderedSequence analysisAdd BLAST20
Regioni3810 – 3830DisorderedSequence analysisAdd BLAST21
Regioni3864 – 3894DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 480Sequence analysisAdd BLAST21
Coiled coili4589 – 4609Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1421 – 1464Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1468 – 1488Polar residuesSequence analysisAdd BLAST21
Compositional biasi1500 – 1514Polar residuesSequence analysisAdd BLAST15
Compositional biasi3810 – 3826Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3868 – 3882Acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000040_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4LN92

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDINDMA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4LN92

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

B4LN92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI
60 70 80 90 100
ADKNVPPDLS QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG
110 120 130 140 150
NAILLRHHNS DMYLACLSTS SSNDKLSFDV GLQEHSQGEA CWWTVHPASK
160 170 180 190 200
QRSEGEKVRV GDDLILVSVA TERYLHTTKE NEQSIVNASF HVTHWSVQPY
210 220 230 240 250
GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG QNIVIYEGGV
260 270 280 290 300
VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL
310 320 330 340 350
VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEIIGSPIIK YGDTTVIVQH
360 370 380 390 400
CESSLWLSYK SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK
410 420 430 440 450
TARVIRKCSS LFTQFITALE TLQSNRRHSV FFQKVNLNEM VMCLEDLINY
460 470 480 490 500
FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE GVLNLILEAI DKINIITSQG
510 520 530 540 550
FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF ANSNRLNWLF
560 570 580 590 600
SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP
660 670 680 690 700
NIFVGRVDGS SMYQKWYFEV TMDHIEQTTH IMPHLRIGWA NTSGYVPYPG
710 720 730 740 750
GGKKWGGNGV GDDLYSFGFD GAHLWTGGRK SLVVDALPEE PFIRKGDVIG
760 770 780 790 800
VAIDLSVPVI TFTFNGAKVR GCFRDFNLDG MFFPVMSCSS KLSCRFLFGG
810 820 830 840 850
DHGRLKYAPP MGFSALVQCL MPHQILSLDP CFYFGNLSKN VLAGPWLIED
860 870 880 890 900
DTPFVPKPVD TTGVSLPSSV DQIKEKLAEN IHEMWALNKI DAGWTWGEHR
910 920 930 940 950
DDYHRIHPCL TQFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR
960 970 980 990 1000
IRPVRLPNEI FMQANGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR
1010 1020 1030 1040 1050
ERIQQGWTYG LNEDSENHRS PHLVPYAKVD EAIKKANRDT ASETVRTLLV
1060 1070 1080 1090 1100
YGYVLDPPTG EGTEALLAEA QRLKFAAFRT YRVERNYAVT SGKWYFEFEV
1110 1120 1130 1140 1150
LTAGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNVTKMHA GTIEHFGVRY
1160 1170 1180 1190 1200
EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC
1210 1220 1230 1240 1250
TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ
1260 1270 1280 1290 1300
PIFENTEEMP DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS
1310 1320 1330 1340 1350
LPVTCMSDFI SEQEKARRWE EIKIRQYRLM REAQEAAAQM QTQTVAHMDH
1360 1370 1380 1390 1400
MLKGGFNMND IKGLTRNFDD HAEAEAEHMM RVPSRPSRKG SLTRNITFES
1410 1420 1430 1440 1450
DMTAALDEMQ RSSSVLDING LGDDLDDKKK RGRSPFKFFS KKSRDQSREK
1460 1470 1480 1490 1500
NGARTADASL ERRNTVAHGR NVVNQQMTTR TPTLRLNNAE IPPSPVPQGP
1510 1520 1530 1540 1550
KQLSSSNLGQ PPVESSGNEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG
1560 1570 1580 1590 1600
WVTTQYHLHS REFNKSKVRR GSVYIEDYYE VPIERIDRQS CYVVRADELF
1610 1620 1630 1640 1650
NEVTQDASGK GASQGMFVGC FVDTATGIIR FTCEGKDTSH RWMMEPDTKL
1660 1670 1680 1690 1700
FPAIFVEATS KEILQIELGR TPTTLPLSAA VLPTSDKHIN PQSPPRLKVQ
1710 1720 1730 1740 1750
CLRPHQWARV PNTSLQVHAL KLSDIRGWSM LCEDPISMLA LHIPEEDRCI
1760 1770 1780 1790 1800
DILELIEMDK LLSFHAHTLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI
1810 1820 1830 1840 1850
RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GVELKELYAE
1860 1870 1880 1890 1900
DEMRHSLRSL VTESVRPQLR MTEITPPVIA TSIMPSVSSE PIPNIDQLYS
1910 1920 1930 1940 1950
PKFPLEVVRE FVMEALKDAV EINQVHNRDP IGWTNENLFL PLIKLTDRLL
1960 1970 1980 1990 2000
LVGVLTDEDV QKLLVMVDPE TWDATFEKEG KDEHRKGLLT MKMAEGAKLQ
2010 2020 2030 2040 2050
MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI EIKQSDLPSA
2060 2070 2080 2090 2100
VAAKKTKEFR CPPREQMNQI LCFKNLEVDD QDNCTCGLEL RSRLSEFHDC
2110 2120 2130 2140 2150
LMQKVSLNAL QEPDGTESNA IEEIKTGPIT KIYNFINTVK ELEEGPKEVE
2160 2170 2180 2190 2200
EPEKKTPEEI FRKVLIKTIV SWAEESQIEN PKLVREMFSL LVRQYDTVGE
2210 2220 2230 2240 2250
LVRALEKTYV INNRARDDVA EMWVGLSQIR ALLPVQMSQE EEELMRKRLW
2260 2270 2280 2290 2300
KLVNNATFFQ HPDLIRILRV HENVMAVMMN TLGRRAQAQS DAPTQTEGAE
2310 2320 2330 2340 2350
GVPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLDNANILL
2360 2370 2380 2390 2400
ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE
2410 2420 2430 2440 2450
LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE
2460 2470 2480 2490 2500
CLGPALRGEG EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL
2510 2520 2530 2540 2550
PEGDEDEDYI DTGAAILNFY CTLVDLLGRC APDVSVIEQG KNESLRARAI
2560 2570 2580 2590 2600
LRSLVPLEDL QGVLSLKFTL TQTAPGEERP KSDMPSGLLP NNKQSIVLFL
2610 2620 2630 2640 2650
ERVYGIETQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM ALAMNRYIGN
2660 2670 2680 2690 2700
SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF
2710 2720 2730 2740 2750
LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG
2760 2770 2780 2790 2800
STQGQGSYGA SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI
2810 2820 2830 2840 2850
GCALPPDYSL SKNTDEDYYG RQMGAPDQPQ YVPNPIDTNN VHLDNDLNSL
2860 2870 2880 2890 2900
VQKFSEHYHD AWASRRLEGG WTYGEVRSDN DRKHPRLKPY NMLSEYERER
2910 2920 2930 2940 2950
YRDPVRECLK GLLAIGWTVE HSEMDLPLNH RGSTRRQSKP TIHDFQNEGS
2960 2970 2980 2990 3000
PFNYNPHPVD MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELDGCGGVI
3010 3020 3030 3040 3050
HPQLVPYDLL TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA
3060 3070 3080 3090 3100
TQAAVELRFS YSLLEKLIQY LDRATINMKL LKPSTTFSRR TSFKTASRDI
3110 3120 3130 3140 3150
KFFSKVVLPL MEKYFSTHRN YFIAIATATN NIGAASLKEK EMVASIFCKL
3160 3170 3180 3190 3200
AALLRNRLSA FGPDVRITVR CLQVLVKGID AKTLTKNCPE FIRTSMLTFF
3210 3220 3230 3240 3250
NQTSDDLGNT IMNLQDGKYS HLRGTHLKTS TSLGYVNQVV LPVLTAMFDH
3260 3270 3280 3290 3300
LAACDYGSDL LLDEIQVASY KILAALYHLG TDATLTHDRK YLKTEIERHR
3310 3320 3330 3340 3350
PALGSCLGAY SSCFPVAYLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME
3360 3370 3380 3390 3400
SCMPNLEAIL SEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD
3410 3420 3430 3440 3450
NVSPTSGNHV TMVTADHMNS LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ
3460 3470 3480 3490 3500
IIINTSEELL KDPFLPLAER VKKRTENMLH KEESMRGFIK SATDDTSQVE
3510 3520 3530 3540 3550
TQLQEDWNLL VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA EELYNHVAEI
3560 3570 3580 3590 3600
FNIWSKSQYF LKEEQNFISA NEIDNMALIM PTATRRSAIS EGVPAVGGKV
3610 3620 3630 3640 3650
KKKKKNRDKK RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD
3660 3670 3680 3690 3700
RYLKKMPEYD VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEETVDE
3710 3720 3730 3740 3750
QALEKVNTNS NEKGKDKTTE TVDRIVAMAK VLFGLHMIDH PQQQSKNVYR
3760 3770 3780 3790 3800
SVVSIQRKRA VIACFRQTSL HSLPRHRACN IFARTYYEQW LQEENVGQEV
3810 3820 3830 3840 3850
MIEDLTQTFE ESEKSKKDEE EADGKPDPLT QLVTTFCRGA MTERSGALQE
3860 3870 3880 3890 3900
DLLYMSYAQI AAKSCGEEEE EGGEDGEAGE GGEEGEGTSI HEQEMEKQKL
3910 3920 3930 3940 3950
LFHQARLSNR GVAEMVLLHI SASKGIPSEM VMTTLNLGIA ILRGGNIDIQ
3960 3970 3980 3990 4000
MGMLNHLKEK KDVGFFTSIA GLMNSCSVLD LDAFERNTKA EGLGVGSEGA
4010 4020 4030 4040 4050
AGEKNMHDAE FTCALFRFIQ LTCEGHNLEW QNYLRTQAGN TTTVNVVICT
4060 4070 4080 4090 4100
VDYLLRLQES IMDFYWHYSS KEIIDPAGKA NFFKAIGVAS QVFNTLTEVI
4110 4120 4130 4140 4150
QGPCTLNQQA LAHSRLWDAV GGFLFLFSHM QDKLSKHSSQ VDLLKELLNL
4160 4170 4180 4190 4200
QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESAGNVELIL KYFDMFLKLA
4210 4220 4230 4240 4250
DLIESPSFHE IDMKNEGWVI PKDFREKMEQ SKNYTPEEMD FLLACCERNH
4260 4270 4280 4290 4300
EGKIDYRAFV ERFHEPSKEI GFNLAVLLTN LSEHMPNEPR LARFLETAGS
4310 4320 4330 4340 4350
VLNYFEPFLG RIEILGSSKR IERVYFEIKD SNIEQWEKPQ IRESKRAFFY
4360 4370 4380 4390 4400
SIVTEGGDKE KLEAFVNFCE DAIFEMTHAS GLMATDDGGS NVKRDTAYSS
4410 4420 4430 4440 4450
YMSEEEEERA ARDPIRRTIT AVKEGLKFGV HMLSPSNIKH QIGVMQTKSI
4460 4470 4480 4490 4500
PELIVGFFKI IFYMFYYTGY AHYCVVRYIF GILLNLMRGP APEQEEEEAV
4510 4520 4530 4540 4550
VEEETFGRAL PPLPLEEPPG TVQAFGLDIN KEENGMYKVV VHESPAGSSV
4560 4570 4580 4590 4600
EEGGESSPED GAAATAEFIE GEPYQEPISI VDLLGGEAAK KAAQERQEAQ
4610 4620 4630 4640 4650
KAQEAAMASI EAEAKKSSAA PQETPAVHQI DFSQYTHRAV SFLARNFYNL
4660 4670 4680 4690 4700
KYVALVLAFS INFMLLFYKV TSYPEESEGS GEDELILGSG SGGGADVAGS
4710 4720 4730 4740 4750
GLGGSGDGGS GDGDFDEDDI PELVHVDEDF FYMEHVLRIA ALLHSLVSLA
4760 4770 4780 4790 4800
MLIAYYHLKV PLAIFKREKE IARRLEFDGL FIAEQPEDDD FKSHWDKLVI
4810 4820 4830 4840 4850
SAKSFPVNYW DKFVKKKVRQ KYSETYDFDS ISNLLGMEKS AFTAQESEET
4860 4870 4880 4890 4900
GILRYIMNID WRYQVWKAGV TFTDNAFLYS LWYFSFSVMG NFNNFFFAAH
4910 4920 4930 4940 4950
LLDVAVGFKT LRTILQSVTH NGKQLVLTVM LLTIIVYIYT VIAFNFFRKF
4960 4970 4980 4990 5000
YIQEEDEEVD KKCHDMLTCF VFHLYKGVRA GGGIGDEIGD PDGDDYEVYR
5010 5020 5030 5040 5050
IIFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQLESVKDN MESNCFICGM
5060 5070 5080 5090 5100
GKDFFDIVPH GFDTHVQKEH NLANYMFFLM HLINKPDTEY TGQETYVWNM
5110 5120 5130
YQQRSWDFFP VGDCFRKQYE DELSGGGGGG G
Length:5,131
Mass (Da):581,509
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD571A4349016B00C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0Q9WE45A0A0Q9WE45_DROVI
Uncharacterized protein, isoform D
Dvir\GJ21297 Dvir_GJ21297
5,117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2M0A0A0Q9W2M0_DROVI
Uncharacterized protein, isoform C
Dvir\GJ21297 Dvir_GJ21297
5,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9WAI9A0A0Q9WAI9_DROVI
Uncharacterized protein, isoform M
Dvir\GJ21297 Dvir_GJ21297
5,112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W292A0A0Q9W292_DROVI
Uncharacterized protein, isoform P
Dvir\GJ21297 Dvir_GJ21297
5,131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2A9A0A0Q9W2A9_DROVI
Uncharacterized protein, isoform O
Dvir\GJ21297 Dvir_GJ21297
5,121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2D4A0A0Q9W2D4_DROVI
Uncharacterized protein, isoform B
Dvir\GJ21297 Dvir_GJ21297
5,127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2E9A0A0Q9W2E9_DROVI
Uncharacterized protein, isoform R
Dvir\GJ21297 Dvir_GJ21297
5,138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2H0A0A0Q9W2H0_DROVI
Uncharacterized protein, isoform N
Dvir\GJ21297 Dvir_GJ21297
5,132Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W2V7A0A0Q9W2V7_DROVI
Uncharacterized protein, isoform H
Dvir\GJ21297 Dvir_GJ21297
5,134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0Q9W369A0A0Q9W369_DROVI
Uncharacterized protein, isoform L
Dvir\GJ21297 Dvir_GJ21297
5,125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH940648 Genomic DNA Translation: EDW60096.1

NCBI Reference Sequences

More...
RefSeqi
XP_002048903.1, XM_002048867.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0237222; FBpp0235714; FBgn0208429

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940648 Genomic DNA Translation: EDW60096.1
RefSeqiXP_002048903.1, XM_002048867.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7244.FBpp0235714

Genome annotation databases

EnsemblMetazoaiFBtr0237222; FBpp0235714; FBgn0208429

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
HOGENOMiCLU_000040_2_0_1
InParanoidiB4LN92
OMAiKDINDMA
PhylomeDBiB4LN92

Gene expression databases

BgeeiFBgn0208429, Expressed in adult organism and 1 other tissue

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4LN92_DROVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4LN92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 29, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again