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Protein

Protein cueball

Gene

cue

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role in spermatogenesis and oogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Oogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cueballBy similarity
Gene namesi
Name:cueBy similarity
ORF Names:GJ12465
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0199707 Dvir\GJ12465

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 517ExtracellularSequence analysisAdd BLAST490
Transmembranei518 – 538HelicalSequence analysisAdd BLAST21
Topological domaini539 – 636CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000038657828 – 636Protein cueballSequence analysisAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi359 ↔ 372PROSITE-ProRule annotation
Disulfide bondi374 ↔ 383PROSITE-ProRule annotation
Disulfide bondi423 ↔ 433PROSITE-ProRule annotation
Disulfide bondi427 ↔ 444PROSITE-ProRule annotation
Disulfide bondi446 ↔ 455PROSITE-ProRule annotation
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiB4LCX4

Expressioni

Gene expression databases

BgeeiFBgn0199707 Expressed in 1 organ(s), highest expression level in adult organism

Structurei

3D structure databases

ProteinModelPortaliB4LCX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 169LDL-receptor class B 1Sequence analysisAdd BLAST48
Repeati170 – 214LDL-receptor class B 2Sequence analysisAdd BLAST45
Repeati215 – 260LDL-receptor class B 3Sequence analysisAdd BLAST46
Domaini350 – 384EGF-like 1PROSITE-ProRule annotationAdd BLAST35
Domaini419 – 456EGF-like 2PROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the cueball family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPSX Eukaryota
ENOG410XPMR LUCA
InParanoidiB4LCX4
OMAiETPCFDP
OrthoDBiEOG091G0PM5
PhylomeDBiB4LCX4

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00135 LY, 3 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS51120 LDLRB, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4LCX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLCTSQQFG VAVLFIVLNI CSPLADASPI AWDFAVTLRD KILFVDNRWR
60 70 80 90 100
TIGSAAHEFE ELSALAFDEA EELIYFNDQQ HQNGSIFSLR RDATVASHIV
110 120 130 140 150
EQAVQRTGND SVSGLAYDPL NRNLFWADMR QSKIYFASID TLYTEPPKVL
160 170 180 190 200
VDLSAEGGRP DGVAVDICRR QLYWTNCKIN HATVERIGLN GTGRETIIKQ
210 220 230 240 250
DIDMPRGIVI DQLSDRIFWI DDKVGIFFAL ESARLDGSDR QLVLKDKHQS
260 270 280 290 300
PIQLAITEDT IYWTDKADKA VWSYPKPAYN KPATNSSETQ PQPTKLASWK
310 320 330 340 350
DDVYGIVART GFYQHLQKDA HCASVVRKVK QRLDNKLNNR THERSAVEER
360 370 380 390 400
MDALEREHCL NGASYMSRGN FCICPVGYKG ARCEISECHN FCVHGTCEIS
410 420 430 440 450
DMGYPKCYCQ EDFYGERCEY YKCNGHCLND GHCLVDKESG ELSCDCRENF
460 470 480 490 500
TGTRCEHNET AHCASYCQHL KQHPDAFVPA SCVDICEELH LSNGTIVTEY
510 520 530 540 550
QAAAPLCADG PSSLRSGSVI IVLVVGIVSS LALVAVIVHG LRLIYKPKRP
560 570 580 590 600
RIKKTFVVRK QARLNSASDT PLTNRPLATE QCEITIENCC NMNICETPCF
610 620 630
DPKLVEQQFA ARDRKSPCVK EDKKILIHNM EDDLLT
Length:636
Mass (Da):71,607
Last modified:September 23, 2008 - v1
Checksum:i0A45D1C702FA06FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940647 Genomic DNA Translation: EDW68835.1
RefSeqiXP_002046493.1, XM_002046457.2

Genome annotation databases

EnsemblMetazoaiFBtr0228390; FBpp0226882; FBgn0199707
GeneIDi6622899
KEGGidvi:Dvir_GJ12465

Similar proteinsi

Entry informationi

Entry nameiCUE_DROVI
AccessioniPrimary (citable) accession number: B4LCX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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