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Protein

MAU2 chromatid cohesion factor homolog

Gene

GI22403

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
MAU2 chromatid cohesion factor homolog
Alternative name(s):
Cohesin loading complex subunit SCC4 homolog
Gene namesi
ORF Names:GI22403
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0145131 Dmoj\GI22403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003827331 – 625MAU2 chromatid cohesion factor homologAdd BLAST625

Proteomic databases

PRIDEiB4K4X6

Expressioni

Gene expression databases

BgeeiFBgn0145131 Expressed in 2 organ(s), highest expression level in head

Interactioni

Subunit structurei

Interacts with Nipped-B to form the cohesin loading complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 129TPR 1Add BLAST34
Repeati451 – 484TPR 2Add BLAST34
Repeati491 – 524TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the SCC4/mau-2 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoidiB4K4X6
KOiK11266
OMAiMQAGYMD
OrthoDBiEOG091G06A2
PhylomeDBiB4K4X6

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019440 MAU2
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR21394 PTHR21394, 1 hit
PfamiView protein in Pfam
PF10345 Cohesin_load, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

B4K4X6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVSTTPAS QDACYISLLG LAEYFRTSQP PNIKKCIQCL QALFTFQPPS
60 70 80 90 100
KVEARTHLQM GQVLMAYTCN IDLARRHLEQ AWSIAEPLMN FDDVKFDTAS
110 120 130 140 150
LLAQLHLKTE QSSHAKAMLR RAVELSQNNV YWHCKLLLQL SQIHASDREY
160 170 180 190 200
SLASDLLAVG AESAEEAGAT YLKVLFLLSR AMILMIERKT NDVLALLNSA
210 220 230 240 250
GQIIDNNIPN PHQKEYLKVF FLVLQVCYYL ALGQVKTVKP SLKQLQMSIQ
260 270 280 290 300
TIMAPNWPSD ETIFGGNQLE MFVWLPKEQL YVLVYLVTVS HSMMAGYMDK
310 320 330 340 350
AQKYTEKALT QIEKLKQQED KSILSVFKVI LLEHIVMCRM VMGNRELAIR
360 370 380 390 400
EIAAARDVCL AVPHRNLLKR HSAQLHCLIG LYSMSTSFFE HAERQFLVCV
410 420 430 440 450
NETTERDLKL FANLNLAIIY LRTKREADLK QILDAVSTEN THTYSSQALM
460 470 480 490 500
GGFYYVQGLH AFHKNSFHEA KRFLRETLKM ANAEDLNRLT SCSLVLLSHV
510 520 530 540 550
FLSIGNSKES MNMVTPAMQL ASKIPDIHVQ LWGSAILKDL HRMSKDAQHE
560 570 580 590 600
KEAYANHVKY SENLIADQRK CVQSAHHELI NWFQGNPPVT SNSSLNPAVT
610 620
VPTTETSTSA LQQPQQPAAQ FGQFY
Length:625
Mass (Da):70,787
Last modified:September 23, 2008 - v1
Checksum:iBF3E88F72D75A344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA Translation: EDW16129.1
RefSeqiXP_002000668.1, XM_002000632.2

Genome annotation databases

EnsemblMetazoaiFBtr0173128; FBpp0171620; FBgn0145131
GeneIDi6574634
KEGGidmo:Dmoj_GI22403

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA Translation: EDW16129.1
RefSeqiXP_002000668.1, XM_002000632.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4K4X6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0173128; FBpp0171620; FBgn0145131
GeneIDi6574634
KEGGidmo:Dmoj_GI22403

Organism-specific databases

FlyBaseiFBgn0145131 Dmoj\GI22403

Phylogenomic databases

InParanoidiB4K4X6
KOiK11266
OMAiMQAGYMD
OrthoDBiEOG091G06A2
PhylomeDBiB4K4X6

Gene expression databases

BgeeiFBgn0145131 Expressed in 2 organ(s), highest expression level in head

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019440 MAU2
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR21394 PTHR21394, 1 hit
PfamiView protein in Pfam
PF10345 Cohesin_load, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCC4_DROMO
AccessioniPrimary (citable) accession number: B4K4X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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