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Entry version 57 (08 May 2019)
Sequence version 1 (23 Sep 2008)
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Protein

Protein clueless

Gene

clu

Organism
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein cluelessUniRule annotation
Alternative name(s):
Clustered mitochondria protein homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cluUniRule annotation
ORF Names:GH22778
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7222 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001070 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003663811 – 1494Protein cluelessAdd BLAST1494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B4JW99

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7222.FBpp0156684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4JW99

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini432 – 674CluPROSITE-ProRule annotationAdd BLAST243
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1138 – 1171TPR 1Add BLAST34
Repeati1264 – 1297TPR 2Add BLAST34
Repeati1299 – 1332TPR 3Add BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1839 Eukaryota
ENOG410XQUQ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4JW99

KEGG Orthology (KO)

More...
KOi
K03255

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFPMDGQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4JW99

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466 CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.2280.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03013 CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR007967 GSKIP_dom
IPR023231 GSKIP_dom_sf
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF05303 DUF727, 1 hit
PF12807 eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823 CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4JW99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALEIDAKNA TAATGDAGGA TGGKAKAKEN KTNNNNNAAG EKNLVNGSSS
60 70 80 90 100
SSAAAAAKKK GKKNRNKSPP QQDAIEAEAG AALSNGHAVN GVGDGDADAA
110 120 130 140 150
DANANVLADK PDKATAAAEE KSATPDDEAA AAVAAGDDAD LDALNDIGIT
160 170 180 190 200
VNISSPGTDV LSVQLSSMEL VQEIHQLLMD REETCHRTCF SLQLDNVTLD
210 220 230 240 250
NFAELKTIEP LEQGSTIRVV EEPYTMREAR IHVRHVRDLL KNLDPADAYN
260 270 280 290 300
GIDCTSLTYL NTITQGDLLD KKRTRPDSVD CTPPDYVTPG VREPPLLPLH
310 320 330 340 350
PNIKNAKGPQ ALKVLTTSAW NPPPGPRKLH GDLMYLYVVT MEDKRFHISA
360 370 380 390 400
CSKGFYINQS TDDNFNPKPD NPSHLSHSLI DLLSHISPSF RRAFQAIQKR
410 420 430 440 450
RTMRHAFERV ATPYQVYQWS APQLEHTVDA IRAEDAFSSK LGYEEHIPGQ
460 470 480 490 500
TRDWNEELQT TRELPRKTLP ERLLRERAIF KVHGDFVTAA TRGAMAVIDG
510 520 530 540 550
NVLAINPGED AKMQMFIWNN IFFSLGFDVR DHYKELGGDH AAFVAPRYDL
560 570 580 590 600
HGVRVYNAVD VEGLYTLGTV VIDYRGYRVT AQSIIPGILE REQEQSVVYG
610 620 630 640 650
SIDFGKTVLS HPKYLELLRL AGKHLKILPH SVLNERDEPV ELCSSVECKG
660 670 680 690 700
IIGNDGRHYI LDLLRTFPPD VNFLKLEDVQ MSKDLSEMGF PIEHRHKLCC
710 720 730 740 750
LRQELLEAFI EDRYVTFIRI AAAHLQRLNA KKQADKDLPE EQSTEKPTEQ
760 770 780 790 800
SAEKDPMEKE QDKEKEKDKE AKPNTSSTET KSAEAMVNAI REAQSNVAVS
810 820 830 840 850
NEVQAAEVVK RACATVGSLK EKEFDFRFNP DVFSPGIRHI DGPDGGGQSL
860 870 880 890 900
AKQKRLVQDA AEFLVLKQIP AFIKEHTAHS SPPIDGQSLT ESLHSHGINV
910 920 930 940 950
RYLGKVIKML GQMPRMDYLH RIAILELIVR ATKHIYYTYM QSTEPLHLSA
960 970 980 990 1000
AISHFLNCLL TTGPVNPAVS SEEVHKKQLR NNGGKHNKHN KSSKSQAKPQ
1010 1020 1030 1040 1050
SSSSSSSSAA ASTQNGGNNH NSNNSTAAAA GAASSSSASN NSSADWTLVT
1060 1070 1080 1090 1100
PRSLWQQIRK ETKAYWNFEL DCDSVETAGA KYGFLRISLL RAFCLKVGIQ
1110 1120 1130 1140 1150
VLLREYNFES KHKPTFGDDD IVNVFPVVKH ISPRATDAYN FYTTGQAKIQ
1160 1170 1180 1190 1200
QGLLKEGYEL ISEALNLLNN VFGAMHQENG SCLRMLARLS YLLGDAGDAL
1210 1220 1230 1240 1250
AIQQRAVIMS ERVNGIDHPS TILEYTHLSL YSFANGHVGM SLKLLYRARY
1260 1270 1280 1290 1300
LLVLICGEDH PEVALIDSNI SLILHALGEY ELSLRFIEHA LKLNRKYFGD
1310 1320 1330 1340 1350
KAMHVAVSYH LMARTQSCMG DFRSALSNEK ETYSIYKSQM GEKHEKTRES
1360 1370 1380 1390 1400
AECLRLLTHE AVALQRKMND IYSNGKLTSD LPPIHITPPS MGSVLEMLNT
1410 1420 1430 1440 1450
INGILFVHIS QKDIVKVRSE IEKHLKTNTD ENEITDALKT IVAAANNNEN
1460 1470 1480 1490
ATETTKDEGA AAAGAAPGAG ETPVQLTNGG GEETTATATA TVSS
Length:1,494
Mass (Da):164,450
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC80EBBAD7284BCB9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH916375 Genomic DNA Translation: EDV98237.1

NCBI Reference Sequences

More...
RefSeqi
XP_001995165.1, XM_001995129.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6568806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dgr:Dgri_GH22778

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916375 Genomic DNA Translation: EDV98237.1
RefSeqiXP_001995165.1, XM_001995129.1

3D structure databases

SMRiB4JW99
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0156684

Proteomic databases

PRIDEiB4JW99

Genome annotation databases

GeneIDi6568806
KEGGidgr:Dgri_GH22778

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
InParanoidiB4JW99
KOiK03255
OMAiGFPMDGQ
PhylomeDBiB4JW99

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
3.30.2280.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR007967 GSKIP_dom
IPR023231 GSKIP_dom_sf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF05303 DUF727, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLU_DROGR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4JW99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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