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Entry version 61 (07 Oct 2020)
Sequence version 1 (23 Sep 2008)
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Protein

AF4/FMR2 family member lilli

Gene

lilli

Organism
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi930 – 942A.T hookSequence analysisAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Pair-rule protein
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF4/FMR2 family member lilliBy similarity
Alternative name(s):
Protein lilliputianBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lilliBy similarity
ORF Names:GH13637
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7222 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001070 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003946741 – 1883AF4/FMR2 family member lilliAdd BLAST1883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei458PhosphothreonineBy similarity1
Modified residuei488PhosphoserineBy similarity1
Modified residuei490PhosphoserineBy similarity1
Modified residuei887PhosphoserineBy similarity1
Modified residuei888PhosphoserineBy similarity1
Modified residuei953PhosphoserineBy similarity1
Modified residuei955PhosphoserineBy similarity1
Modified residuei1546PhosphoserineBy similarity1
Modified residuei1548PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B4JQ42

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7222.FBpp0147543

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4JQ42

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 178Gln-richSequence analysisAdd BLAST176
Compositional biasi391 – 465Pro-richSequence analysisAdd BLAST75
Compositional biasi526 – 556Gln-richSequence analysisAdd BLAST31
Compositional biasi590 – 630Gly-richSequence analysisAdd BLAST41
Compositional biasi725 – 773Gln-richSequence analysisAdd BLAST49
Compositional biasi792 – 810Ser-richSequence analysisAdd BLAST19
Compositional biasi901 – 1089Ala-richSequence analysisAdd BLAST189
Compositional biasi1044 – 1070Ser-richSequence analysisAdd BLAST27
Compositional biasi1136 – 1399Gln-richSequence analysisAdd BLAST264
Compositional biasi1200 – 1222Ser-richSequence analysisAdd BLAST23
Compositional biasi1558 – 1578Gln-richSequence analysisAdd BLAST21
Compositional biasi1582 – 1614Thr-richSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR32, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_241798_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4JQ42

KEGG Orthology (KO)

More...
KOi
K15194

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLKQADN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4JQ42

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043640, AF4/FMR2_C
IPR000637, HMGI/Y_DNA-bd_CS
IPR007797, TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00354, HMGI_Y, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4JQ42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQQQQQHL QQQQQQHHQQ QQLQQLQQQQ QLPQYNNNLY NLNYNMEDPE
60 70 80 90 100
RRKRREREKY ERQQGIQSDD RETSLFEAPR RLNPSEGDNM ITAALGEFVD
110 120 130 140 150
AKEHMCMNMV GIHRQAPGGG SNARLQGQAT TPIINSLSSI NSTTTTSSSA
160 170 180 190 200
SLLPGQLPTS QQQQQQQQQQ QQHYQQQQRA PTYLKQADNK PPYNGRGGYP
210 220 230 240 250
GQPMKNDIPS SSGMAPPRGP PRSASSSSSA SNNNSSSATN NATAAAATSA
260 270 280 290 300
STAPLLGPPM STQMPNGREK SYLGPPAPAL SNGGRFVPPA ASGKRTSNTA
310 320 330 340 350
GLQPPPPEKD ISKIINEMTN SYRVTPLTSI AATPHAPTRE NYNLNGPNKN
360 370 380 390 400
KYAFDDVEPI GPLNSPPAAS GASSSSLSCT TNSSSSLLMT PLLAPIAPIT
410 420 430 440 450
SPIAPLLTTP PQASQLPLPL PLLPPLAGAT TVLPPALGMA AVAPIQQLMP
460 470 480 490 500
TPPKASPTPP TAIRPLKSEK NHSLEKQDSC LENDLELSES DDDRKRDICS
510 520 530 540 550
AGNSSNSSET DSSESGSEAS SKGEAQQQQQ QQQQLLHHQH QQQLLLQQQQ
560 570 580 590 600
QQQQQQRATA TTANGGNKKK CQTIIASGAN TISGLLTSSG LGGSGGAVNA
610 620 630 640 650
TSNTNSGLLG GGGGSGSTGG GGGSSSSGMG NMSSSSSSNK TPSPTDSNRW
660 670 680 690 700
HLSRFFPKPT NQATAESVSP GNVACGNVSM KVPGILPGGA QIIPESIDVT
710 720 730 740 750
TAIVKNEKLH DDTRRITDDE DEDEQQQQRY AAGLSVTVKK EQQEQQQQQQ
760 770 780 790 800
QQQQQQQQQQ QQQQQQQQLS AEQLALAGAL PNNQIKREVR LSDSASISSG
810 820 830 840 850
SASGSSSSDS AAGEVVPLPG PGETLQIPGV PAAITTVLRV PPAMQQKVPP
860 870 880 890 900
NSVTLTPIGP LPASPKPRQK KPRKKKMSAA TAPPLDSSDE DEPASSNKKH
910 920 930 940 950
ALELAATTAA AAAAIAAAPA ATAAALPAVK KGRGRPRKQQ QQLQQTQSGN
960 970 980 990 1000
LSSASAGSLA KGPTLTAAKK PLAKSTAAAA AAAALAATAL TVAGSRKREH
1010 1020 1030 1040 1050
SSNSSSNGNT PTKKLHAAPA TVAAAAAAAA AATTLLPPTA AAGSSSDEDS
1060 1070 1080 1090 1100
TSSSCSSTKS SNSSSSGSDS EATATTAAAA TTAAAAAAAT TTTTQNPAKK
1110 1120 1130 1140 1150
RIVKINKLGV VSSSKNNRLY GAGSSSNSSS SETEEQQQQQ QQHKQQQQLL
1160 1170 1180 1190 1200
LMQQQQQQQQ QQQQKQQLQQ HQQQQPLQPQ QQQQQQSHFT PDAKQARQRS
1210 1220 1230 1240 1250
SSSDGSSSSS TDSSSTNSSS SSDEVDVHHG GGKRKSDKKK ICTLTRIFNP
1260 1270 1280 1290 1300
KEGGAKKQGQ VVIIDQSEEQ LQQQQQQLQQ QQQQQQQHQQ QQQQQQQQEQ
1310 1320 1330 1340 1350
QQSKEWKPRA TPTQLLGATL ASPARTTTPH LTSLMCKIDL SKLARVPPEW
1360 1370 1380 1390 1400
YQKSYRQYAA EQQQQQQQHL HTQQLHHPPH HQHQHYQQQH QPHQQKAQQN
1410 1420 1430 1440 1450
GHLSSRSAEG ARTPKELQQA YGMPNGYVTS GGAAGAAGAA SKLLGGVKHE
1460 1470 1480 1490 1500
HGVKPEPELD AGYEAKYKPN SVKQEFMPKQ EMPTRRRKRS SSSSPYKEKK
1510 1520 1530 1540 1550
RKKEKADQVS KELLPVPVLL PANNHERLSR DKLELLQQEI SSANGSPTKR
1560 1570 1580 1590 1600
SFPLAHAQQQ QHQQQQQQQQ HQPQHQQQLK ATTTTSTTAT VAAVQTSTTA
1610 1620 1630 1640 1650
TQQPTTCSEA VQTTPPPVAP PPPPRLIYRS HFDNEEEPPS DDLRKNEILL
1660 1670 1680 1690 1700
QEAIRRKRAA DSERDSFKQM TLYLEAIVYF LLTADAMERS NMEATWTMYK
1710 1720 1730 1740 1750
DTLTLIKFIS SKNRPYQQST NGKHESHNIV AILSLRCQSL ISLKLYKLRR
1760 1770 1780 1790 1800
ANCRAIIASC SEFFRTGGRG DILNGNTLSS ISPSNSVGSQ GSGSNTPPGR
1810 1820 1830 1840 1850
IVPQDIHNQL CRQNEYLTYV NSAHDLWDQA DRLVRTGNHI DFIRKLDHEN
1860 1870 1880
GPMTLHSTMH EVFRYVQAGL KTLRDSVSYP QSQ
Length:1,883
Mass (Da):202,795
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E1CABEFD85FD9ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH916372 Genomic DNA Translation: EDV99022.1

NCBI Reference Sequences

More...
RefSeqi
XP_001993097.1, XM_001993061.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dgr:Dgri_GH13637

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916372 Genomic DNA Translation: EDV99022.1
RefSeqiXP_001993097.1, XM_001993061.1

3D structure databases

SMRiB4JQ42
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0147543

Proteomic databases

PRIDEiB4JQ42

Genome annotation databases

KEGGidgr:Dgri_GH13637

Phylogenomic databases

eggNOGiENOG502QR32, Eukaryota
HOGENOMiCLU_241798_0_0_1
InParanoidiB4JQ42
KOiK15194
OMAiYLKQADN
PhylomeDBiB4JQ42

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
lilli, fly

Family and domain databases

InterProiView protein in InterPro
IPR043640, AF4/FMR2_C
IPR000637, HMGI/Y_DNA-bd_CS
IPR007797, TF_AF4/FMR2
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PROSITEiView protein in PROSITE
PS00354, HMGI_Y, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFFL_DROGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4JQ42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: September 23, 2008
Last modified: October 7, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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