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Entry version 62 (23 Feb 2022)
Sequence version 1 (23 Sep 2008)
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Protein

Facilitated trehalose transporter Tret1

Gene

Tret1

Organism
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Facilitated trehalose transporter Tret1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tret1By similarity
ORF Names:GH21392
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7222 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001070 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 462CytoplasmicSequence analysisAdd BLAST462
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei463 – 483Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini484 – 512ExtracellularSequence analysisAdd BLAST29
Transmembranei513 – 533Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini534 – 541CytoplasmicSequence analysis8
Transmembranei542 – 562Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini563 – 569ExtracellularSequence analysis7
Transmembranei570 – 590Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini591 – 596CytoplasmicSequence analysis6
Transmembranei597 – 617Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini618 – 624ExtracellularSequence analysis7
Transmembranei625 – 645Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini646 – 708CytoplasmicSequence analysisAdd BLAST63
Transmembranei709 – 729Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini730 – 745ExtracellularSequence analysisAdd BLAST16
Transmembranei746 – 766Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini767 – 772CytoplasmicSequence analysis6
Transmembranei773 – 793Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini794 – 804ExtracellularSequence analysisAdd BLAST11
Transmembranei805 – 825Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini826 – 839CytoplasmicSequence analysisAdd BLAST14
Transmembranei840 – 860Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini861 – 873ExtracellularSequence analysisAdd BLAST13
Transmembranei874 – 894Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini895 – 929CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003955441 – 929Facilitated trehalose transporter Tret1Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei320PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei917PhosphoserineBy similarity1
Modified residuei918PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7222.FBpp0155298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B4J913

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 275DisorderedSequence analysisAdd BLAST275
Regioni352 – 371DisorderedSequence analysisAdd BLAST20
Regioni398 – 420DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 73Polar residuesSequence analysisAdd BLAST15
Compositional biasi87 – 141Polar residuesSequence analysisAdd BLAST55
Compositional biasi142 – 167Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi168 – 185Polar residuesSequence analysisAdd BLAST18
Compositional biasi214 – 254Polar residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysisBy similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0254, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016710_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4J913

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFIWTQS

Database of Orthologous Groups

More...
OrthoDBi
430696at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4J913

Family and domain databases

Conserved Domains Database

More...
CDDi
cd17358, MFS_GLUT6_8_Class3_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846, MFS_dom
IPR044775, MFS_ERD6/Tret1-like
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083, Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171, SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879, SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits
PS00217, SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4J913-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRDNRAAG AGGGSGGGGG GGGGGGNHHH HHQPLSNAMG KLKEKLTRAG
60 70 80 90 100
EELGYHRVES NLSASNTATS LDTILPEDPF PFPQAAPQRH PQQQFPFLQQ
110 120 130 140 150
QPQQQQQPQQ QQQPQQQQQL QQHHTQHTQY QQQQQQQQPL RLLHDIDDEQ
160 170 180 190 200
PLSFRPLLED DDIHEPPQEI QQQQLQQQRG NLRASGSLEL TPLPPPPTSL
210 220 230 240 250
EPHRDRQQRS VVNEELQRSK QSLKGSRVSF ERAPQQSNSN NNSKNNSKTT
260 270 280 290 300
VAADASDDDS FEDRRVGYQQ QKATSVDHKG ILKDLRHILA SDNRRQFQAK
310 320 330 340 350
KHVSLDIKGT PFLQDLLKDS SSEEEFHKTR REFQGRKHQS LDPRVTFKLD
360 370 380 390 400
KVLHGSSTDS DEEGEDAEHK RLIHRPKDIT KPVIIDLKDL ESESDEDFLS
410 420 430 440 450
SRQNFQQQRS ISTDSRKSRR LYEMDEMGNK RGENIRHAVP FVRQITEDGK
460 470 480 490 500
PKLEVYRPTT NPIYIWTQVL AALSVSLGSL VVGFSSAYTS PALVSMTDRN
510 520 530 540 550
LTSFDVSTED ASWVGGIMPL AGLAGGIAGG PLIEYLGRRN TILATAVPFI
560 570 580 590 600
ISWLLIACAV NVPMVLSGRF LAGFCVGIAS LSLPVYLGET VQPEVRGTLG
610 620 630 640 650
LLPTAFGNIG ILLCFIAGTY MDWSMLAFLG GALPVPFLIL MFLIPETPRW
660 670 680 690 700
YVSRGREERA RKALVWLRGV EADVEPELKG LMRSQADADR QATHNTMLEL
710 720 730 740 750
LKRSNLKPLS ISLGLMFFQQ LSGINAVIFY TVQIFKDAGS TLDGNVCTII
760 770 780 790 800
VGTVNFIATF IGILLIDRAG RKILLYVSNI AMILTLFVLG GFFYCKANGM
810 820 830 840 850
DVSNVGLLPL CCFVVYILGF SLGFGPIPWL MMGEILPAKI RGSAASVATA
860 870 880 890 900
FNWTCTFVVT KSFLDMIKLI GAHGAFWLFG VICCIGMFFV IFCVPETQGK
910 920
TLEDIERKMM GRVRRMSSVA NIKPLSFNM
Length:929
Mass (Da):103,238
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB493B09443624DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH916367 Genomic DNA Translation: EDW01362.1

NCBI Reference Sequences

More...
RefSeqi
XP_001986495.1, XM_001986459.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0465561; FBpp0415803; FBgn0128854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6559185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dgr:Dgri_GH21392

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916367 Genomic DNA Translation: EDW01362.1
RefSeqiXP_001986495.1, XM_001986459.1

3D structure databases

SMRiB4J913
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0155298

Genome annotation databases

EnsemblMetazoaiFBtr0465561; FBpp0415803; FBgn0128854
GeneIDi6559185
KEGGidgr:Dgri_GH21392

Phylogenomic databases

eggNOGiKOG0254, Eukaryota
HOGENOMiCLU_016710_0_0_1
InParanoidiB4J913
OMAiIFIWTQS
OrthoDBi430696at2759
PhylomeDBiB4J913

Family and domain databases

CDDicd17358, MFS_GLUT6_8_Class3_like, 1 hit
Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR020846, MFS_dom
IPR044775, MFS_ERD6/Tret1-like
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 1 hit
PRINTSiPR00171, SUGRTRNSPORT
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00879, SP, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits
PS00217, SUGAR_TRANSPORT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRET1_DROGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4J913
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: February 23, 2022
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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