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Protein

L-lactate dehydrogenase

Gene

Dgri\GH16279

Organism
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Dgri\GH16279)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Active sitei193Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Dgri\GH16279Imported
ORF Names:Dgri_GH16279Imported, GH16279Imported
OrganismiDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
Proteomesi
  • UP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123750 Dgri\GH16279

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0150185

Structurei

3D structure databases

ProteinModelPortaliB4IXY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 160Ldh_1_NInterPro annotationAdd BLAST139
Domaini163 – 325Ldh_1_CInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
InParanoidiB4IXY2
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG091G0HME
PhylomeDBiB4IXY2

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

B4IXY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTVKESLLA QVAETLPSSG HKITVVGIGM VGMASAFSIL AQGVSREVCL
60 70 80 90 100
IDCCTDKLQG ELMDLQHGSN FLKNPQITAS TDYAASANSR LCIVTAGVRQ
110 120 130 140 150
KEGESRLSLV QRNTDILKSI IPKLVENSPD CILLMVSNPV DIMTYVAWKL
160 170 180 190 200
SGLPKNRVIG SGTNLDSSRF RFLMSQRLGV APTSCHGWII GEHGDSSVPV
210 220 230 240 250
WSGVNIAGVR LRELNPTIGT GSDPEKWNEL HKQVVDSAYE VIKLKGYTSW
260 270 280 290 300
AIGLSTASLA SAILRNTSSV AAISTSVMGE HGIDKDVFLS LPCVLNANGV
310 320 330
TSVVKQILTD TEVQQLQKSA NIMSEVQAGL QF
Length:332
Mass (Da):35,558
Last modified:September 23, 2008 - v1
Checksum:i5704B519708863FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA Translation: EDV96503.1
RefSeqiXP_001984155.1, XM_001984119.1

Genome annotation databases

EnsemblMetazoaiFBtr0151693; FBpp0150185; FBgn0123750
GeneIDi6557546
KEGGidgr:Dgri_GH16279

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA Translation: EDV96503.1
RefSeqiXP_001984155.1, XM_001984119.1

3D structure databases

ProteinModelPortaliB4IXY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0150185

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0151693; FBpp0150185; FBgn0123750
GeneIDi6557546
KEGGidgr:Dgri_GH16279

Organism-specific databases

FlyBaseiFBgn0123750 Dgri\GH16279

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
InParanoidiB4IXY2
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG091G0HME
PhylomeDBiB4IXY2

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB4IXY2_DROGR
AccessioniPrimary (citable) accession number: B4IXY2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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