UniProtKB - B4IL64 (SWS_DROSE)
Protein
Neuropathy target esterase sws
Gene
sws
Organism
Drosophila sechellia (Fruit fly)
Status
Functioni
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholineBy similarityEC:3.1.1.5By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 983 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1103 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 174 – 301 | cNMP 1Sequence analysisAdd BLAST | 128 | |
Nucleotide bindingi | 480 – 607 | cNMP 2Sequence analysisAdd BLAST | 128 | |
Nucleotide bindingi | 596 – 723 | cNMP 3Sequence analysisAdd BLAST | 128 |
GO - Molecular functioni
- lysophospholipase activity Source: UniProtKB
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
- protein kinase A catalytic subunit binding Source: EnsemblMetazoa
GO - Biological processi
- ensheathment of neurons Source: EnsemblMetazoa
- glial cell apoptotic process Source: UniProtKB
- lipid catabolic process Source: UniProtKB-KW
- membrane lipid metabolic process Source: UniProtKB
- membrane organization Source: UniProtKB
- negative regulation of cAMP-dependent protein kinase activity Source: EnsemblMetazoa
- neuron apoptotic process Source: UniProtKB
- phosphatidylcholine metabolic process Source: UniProtKB
- photoreceptor cell maintenance Source: EnsemblMetazoa
- protein localization to membrane Source: EnsemblMetazoa
- sensory perception of smell Source: EnsemblMetazoa
Keywordsi
Molecular function | Developmental protein, Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropathy target esterase swsBy similarityAlternative name(s): Swiss cheeseBy similarity (EC:3.1.1.5) |
Gene namesi | Name:swsBy similarity ORF Names:GM11957 |
Organismi | Drosophila sechellia (Fruit fly) |
Taxonomic identifieri | 7238 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: EnsemblMetazoa
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | LumenalSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 1468 | CytoplasmicSequence analysisAdd BLAST | 1413 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000389226 | 1 – 1468 | Neuropathy target esterase swsAdd BLAST | 1468 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 442 | PhosphoserineBy similarity | 1 | |
Modified residuei | 451 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1197 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.
By similarityGO - Molecular functioni
- protein kinase A catalytic subunit binding Source: EnsemblMetazoa
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 950 – 1116 | PNPLAPROSITE-ProRule annotationAdd BLAST | 167 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 954 – 959 | GXGXXGPROSITE-ProRule annotation | 6 | |
Motifi | 981 – 985 | GXSXGPROSITE-ProRule annotation | 5 | |
Motifi | 1103 – 1105 | DGA/GPROSITE-ProRule annotation | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1420 – 1446 | Gln-richSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the NTE family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_000960_1_0_1 |
OMAi | GHLWRYC |
PhylomeDBi | B4IL64 |
Family and domain databases
CDDi | cd00038, CAP_ED, 3 hits |
Gene3Di | 2.60.120.10, 3 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 3 hits PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 3 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 2 hits |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 3 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
i Sequence
Sequence statusi: Complete.
B4IL64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYCA LVMMSLLFIA
60 70 80 90 100
WFLYFKRMAR LRLRDELARS ISTATNSSGD LRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKVKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN
360 370 380 390 400
GPPMVINQLN LMQSAASGTG SGVSVTVTRP PSSPSRHSRE EHTLSDPNPN
410 420 430 440 450
PDGSFHGTTN LFTEVHGDAP NADLFQQQQQ PSVGNLSTRR SSITLMTPDG
460 470 480 490 500
SHSCVQTPGV TTSIDMRLVQ SSAVDSLRKE LGLSEEDSHI IEPFVELREL
510 520 530 540 550
EPNVTLITEG NADDVCVWFV MTGTLAVYQS NQDATRAKQD KSDMLIHFVH
560 570 580 590 600
PGEIVGGLAM LTGEASAYTI RSRSYARIAF IRRAAIYQIM RQRPRIVLDL
610 620 630 640 650
GNGVVRRLSP LVRQCDYALD WIFLESGRAV YRQDESSDST YIVLSGRMRS
660 670 680 690 700
VITHPGGKKE IVGEYGKGDL VGIVEMITET SRTTTVMAVR DSELAKLPEG
710 720 730 740 750
LFNAIKLRYP IVVTKLISFL SHRFLGSMQT RSGSGAPGAP VEANPVTHKY
760 770 780 790 800
STVALVPITD EVPLTPFTYE LYHSLCAIGP VLRLTSDVVR KQLGSNIFEA
810 820 830 840 850
ANEYRLTSWL AQQEDRNIIT LYQCDSSLSA WTQRCMRQAD VILIVGLGDR
860 870 880 890 900
SHLVGKFERE IDRLAMRTQK ELVLLYPEAT NAKPANTLSW LNARPWVTKH
910 920 930 940 950
HHVLCVKRIF TRKSQYRIND LYSRVLLSEP NMHSDFSRLA RWLTGNSIGL
960 970 980 990 1000
VLGGGGARGA AHIGMLKAIQ EAGIPVDMVG GVSIGALMGA LWCSDRNITT
1010 1020 1030 1040 1050
VTQKAREWSK KMTKWFLQLL DLTYPITSMF SGREFNKTIH DTFGDVSIED
1060 1070 1080 1090 1100
LWIPYFTLTT DITASCHRIH TNGSLWRYVR SSMSLSGYMP PLCDPKDGHL
1110 1120 1130 1140 1150
LLDGGYVNNL PGHLWRYCRA SMSIAGVFPP FCDYRDGHLL LDGCYTNNVP
1160 1170 1180 1190 1200
ADVMHNLGAA HIIAIDVGSQ DDTDLTNYGD DLSGWWLLYK KWNPFTSPVK
1210 1220 1230 1240 1250
VPDLPDIQSR LAYVSCVRQL EEVKNSDYCE YIRPPIDKYK TLAFGSFDEI
1260 1270 1280 1290 1300
RDVGYVFGKN YFENMAKAGR LGRFNQWFNK EPPKRVNHAS LNEYTFIDLA
1310 1320 1330 1340 1350
QIVCRLPETY AVNTAELFSE DEDCDGYISE PTTLNTDRRR IQVSRAGNSL
1360 1370 1380 1390 1400
SFSETEMDSD VELDLKLERK MDKSTQSSPP TSSRTDMRGK EEAKHMANWH
1410 1420 1430 1440 1450
WGVKHKDETG SGATVATHTQ TGQEQELQQQ QKLQQLQQDQ GARAEQLVDK
1460
DKEEDKENRS SPNNETKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH480865 Genomic DNA Translation: EDW53681.1 |
RefSeqi | XP_002044474.1, XM_002044438.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0194942; FBpp0193434; FBgn0166898 |
GeneIDi | 6620266 |
KEGGi | dse:6620266 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH480865 Genomic DNA Translation: EDW53681.1 |
RefSeqi | XP_002044474.1, XM_002044438.1 |
3D structure databases
SMRi | B4IL64 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0194942; FBpp0193434; FBgn0166898 |
GeneIDi | 6620266 |
KEGGi | dse:6620266 |
Phylogenomic databases
HOGENOMi | CLU_000960_1_0_1 |
OMAi | GHLWRYC |
PhylomeDBi | B4IL64 |
Family and domain databases
CDDi | cd00038, CAP_ED, 3 hits |
Gene3Di | 2.60.120.10, 3 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 3 hits PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 3 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 2 hits |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 3 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SWS_DROSE | |
Accessioni | B4IL64Primary (citable) accession number: B4IL64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 24, 2009 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families