UniProtKB - B4HYU0 (B4HYU0_DROSE)
Protein
COP9 signalosome complex subunit 2
Gene
Dsec\GM12583
Organism
Drosophila sechellia (Fruit fly)
Status
Functioni
GO - Molecular functioni
- nuclear receptor binding Source: EnsemblMetazoa
- protein homodimerization activity Source: EnsemblMetazoa
- transcription corepressor activity Source: EnsemblMetazoa
GO - Biological processi
- female germ-line stem cell population maintenance Source: EnsemblMetazoa
- germarium-derived cystoblast division Source: EnsemblMetazoa
- male germ-line cyst encapsulation Source: EnsemblMetazoa
- multicellular organism development Source: EnsemblMetazoa
- negative regulation of transcription, DNA-templated Source: EnsemblMetazoa
- protein stabilization Source: EnsemblMetazoa
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 2ARBA annotation |
Gene namesi | Name:Dsec\GM12583Imported ORF Names:Dsec_GM12583Imported |
Organismi | Drosophila sechellia (Fruit fly)Imported |
Taxonomic identifieri | 7238 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Subcellular locationi
Nucleus
- COP9 signalosome Source: EnsemblMetazoa
Other locations
- cytoplasm Source: UniProtKB-SubCell
- repressor ecdysone receptor complex Source: EnsemblMetazoa
Interactioni
GO - Molecular functioni
- nuclear receptor binding Source: EnsemblMetazoa
- protein homodimerization activity Source: EnsemblMetazoa
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 255 – 417 | PCIInterPro annotationAdd BLAST | 163 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 29 | AcidicSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the CSN2 family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_028981_0_1_1 |
OMAi | NMRTKGV |
PhylomeDBi | B4HYU0 |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
i Sequence
Sequence statusi: Complete.
B4HYU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDNDDDFMC DDDEDYGLEY SEDSNSEPDV DLENQYYNSK ALKEEEPKAA
60 70 80 90 100
LASFQKVLDL ENGEKGEWGF KALKQMIKIN FRLCNYDEMM VRYKQLLTYI
110 120 130 140 150
KSAVTRNHSE KSINSILDYI STSKNMALLQ NFYETTLDAL RDAKNDRLWF
160 170 180 190 200
KTNTKLGKLY FDRSDFTKLQ KILKQLHQSC QTDDGEDDLK KGTQLLEIYA
210 220 230 240 250
LEIQMYTVQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG
260 270 280 290 300
EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA
310 320 330 340 350
KPYKNDPEIL AMTNLVNSYQ NNDINEFETI LRQHRSNIMA DQFIREHIED
360 370 380 390 400
LLRNIRTQVL IKLIRPYKNI AIPFIANALN IEPAEVESLL VSCILDDTIK
410 420 430 440
GRIDQVNQVL QLDKINSSAS RYNALEKWSN QIQSLQFAVV QKMA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH480818 Genomic DNA Translation: EDW52220.1 |
RefSeqi | XP_002036297.1, XM_002036261.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0195568; FBpp0194060; FBgn0167520 |
GeneIDi | 6611774 |
KEGGi | dse:6611774 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH480818 Genomic DNA Translation: EDW52220.1 |
RefSeqi | XP_002036297.1, XM_002036261.1 |
3D structure databases
SMRi | B4HYU0 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0195568; FBpp0194060; FBgn0167520 |
GeneIDi | 6611774 |
KEGGi | dse:6611774 |
Phylogenomic databases
HOGENOMi | CLU_028981_0_1_1 |
OMAi | NMRTKGV |
PhylomeDBi | B4HYU0 |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4HYU0_DROSE | |
Accessioni | B4HYU0Primary (citable) accession number: B4HYU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |