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Entry version 62 (16 Oct 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

GM20311

Gene

Dsec\GM20311

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.090

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GM20311Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dsec\GM20311Imported
ORF Names:Dsec_GM20311Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila sechellia (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7238 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001292 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 600Peptidase_S8InterPro annotationAdd BLAST479
Domaini893 – 1076TPPIIInterPro annotationAdd BLAST184
Domaini1119 – 1256TPPII_NInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 89DisorderedSequence analysisAdd BLAST27
Regioni1142 – 1190DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 77PolarSequence analysisAdd BLAST15
Compositional biasi1151 – 1177PolarSequence analysisAdd BLAST27

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K01280

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRACIDT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4HQ07

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4HQ07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNRLRLVHK QLRLYKNFEL LGQKASVGLT LPIVSLSRPY MAYMGTERSV
60 70 80 90 100
VMITAPATKE FAESSERSNI SKNTTNKEQS DKSAESRMAT SGIVESFPTG
110 120 130 140 150
ALVPKAETGV LNFLQKYPDY DGRDVTIAIF DSGVDPRATG LETLCDGKTV
160 170 180 190 200
KVIERYDCSG CGDVDMKKKV MPDENGNIKG LSGNSLKLSP ELMALNTDPE
210 220 230 240 250
KAVRVGLKSF SDLLPSKVRN NIVAQAKLKH WDKPHKTATA NASRKIVEFE
260 270 280 290 300
SQNPGEASKL PWDKKILKEN LDFELEMLNS YEKVYGDIKT SYDCILFPTA
310 320 330 340 350
DGWLTIVDTT EQGDLDQALR IGEYSRTHET RNVDDFLSIS VNIHDEGNVL
360 370 380 390 400
EVVGMSSPHG THVSSIASGN HSSRDVDGVA PNAKIVSMTI GDGRLGSMET
410 420 430 440 450
GTALVRAMTK VMELCRDGRR IDVINMSYGE HANWSNSGRI GELMNEVVNK
460 470 480 490 500
YGVVWVASAG NHGPALCTVG TPPDISQPSL IGVGAYVSPQ MMEAEYAMRE
510 520 530 540 550
KLPGNVYTWT SRDPCIDGGQ GVTVCAPGGA IASVPQFTMS KSQLMNGTSM
560 570 580 590 600
AAPHVAGAVA LLISGLKQQN IEYSPYSIKR AISVTATKLG YVDPFAQGHG
610 620 630 640 650
LLNVEKAFEH LTEHRQSKDN MLRFSVRVGN NAAKGIHLRQ GVQRNFVDYN
660 670 680 690 700
VFIEPIFYND KEADPKDKFN FNVRLNLIAS QPWVQCGAFL DLSYGTRSIA
710 720 730 740 750
VRVDPTGLQP GVHSAVIRAY DTDCVQKGSL FEIPVTVVQP HVLESDQNTP
760 770 780 790 800
VFEPASSKGD NSVEFQPNTI QRDFILVPER ATWAELRMRI TDPNRGKDIG
810 820 830 840 850
KFFVHTNQLL PKQSCRKLET MKIVSVGSEN ESVMAFKVKS GRILELCIAK
860 870 880 890 900
YWSNYGQSHL KYSLRFRGVE AHNPNAYVMH AGRGIHKLEI EALVAEDVQP
910 920 930 940 950
QLQLKNAEVV LKPTEAKISP LSATRDVIPD GRQVYQNLLT FNLNVAKAAD
960 970 980 990 1000
VSIYAPIFND LLYEAEFESQ MWMLFDANKA LVATGDAHSH TSFTKLDKGE
1010 1020 1030 1040 1050
YTIRLQVRHE KRDLLEKISE ANLVASFKLT NPLTLDFYEN YNQCIVGCRK
1060 1070 1080 1090 1100
YVSSPLRLST RVLYIAPITQ ERLTKANLPA QCAWLSGNLV FPQDEVGRRV
1110 1120 1130 1140 1150
AQHPFTYILN PAEKKAHTNG SSNGSSAAGS TATAAAVTTA NGVKPKAPAT
1160 1170 1180 1190 1200
PQAATSVTNP AAGDGISVQN DPPVDSTGSP ASPKKGKANA DDYAESFRDF
1210 1220 1230 1240 1250
QCSQIVKCEL EMAEKIYNDV VATHPKHLQA NLLLIQNIES NQLKLQLPLT
1260 1270 1280 1290 1300
FVNAQKTSPP EAGESADKQK EDQKKLRSAL ERIVKLADKV IQETDAEALL
1310 1320 1330 1340 1350
SYYGLNSHTR ADAAKIKTKN TLIEALCKKG IAVAKLAVLD DCIKDSLAEI
1360 1370 1380 1390 1400
NDLYTEIIKF VDANDSKAIQ FALWHAYAHG HYGRMYKYVV KLIEEKRTRD
1410 1420 1430
QFVELAAING ALGHEHIRTV INRMMVTAFP SSFRLF
Length:1,436
Mass (Da):158,301
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BC8CE5E1B35C768
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH480816 Genomic DNA Translation: EDW47670.1

NCBI Reference Sequences

More...
RefSeqi
XP_002033657.1, XM_002033621.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0203296; FBpp0201788; FBgn0175194

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6608943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dse:Dsec_GM20311

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480816 Genomic DNA Translation: EDW47670.1
RefSeqiXP_002033657.1, XM_002033621.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiS08.090

Genome annotation databases

EnsemblMetazoaiFBtr0203296; FBpp0201788; FBgn0175194
GeneIDi6608943
KEGGidse:Dsec_GM20311

Phylogenomic databases

KOiK01280
OMAiWRACIDT
PhylomeDBiB4HQ07

Family and domain databases

CDDicd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit
Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain
PfamiView protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4HQ07_DROSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4HQ07
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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