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Protein

Protein cueball

Gene

cue

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role in spermatogenesis and oogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Oogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cueballBy similarity
Gene namesi
Name:cueBy similarity
ORF Names:GL22490
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0160082 Dper\GL22490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 534ExtracellularSequence analysisAdd BLAST512
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 647CytoplasmicSequence analysisAdd BLAST92

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000038657423 – 647Protein cueballAdd BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 389PROSITE-ProRule annotation
Disulfide bondi391 ↔ 400PROSITE-ProRule annotation
Disulfide bondi440 ↔ 450PROSITE-ProRule annotation
Disulfide bondi444 ↔ 461PROSITE-ProRule annotation
Disulfide bondi463 ↔ 472PROSITE-ProRule annotation
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiB4H1F5

Structurei

3D structure databases

ProteinModelPortaliB4H1F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati119 – 166LDL-receptor class B 1Sequence analysisAdd BLAST48
Repeati167 – 211LDL-receptor class B 2Sequence analysisAdd BLAST45
Repeati212 – 257LDL-receptor class B 3Sequence analysisAdd BLAST46
Domaini365 – 401EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini436 – 473EGF-like 2PROSITE-ProRule annotationAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 283Poly-ThrSequence analysis4

Sequence similaritiesi

Belongs to the cueball family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG091G0PM5

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00135 LY, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS51120 LDLRB, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4H1F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWCPSVLVP LIAVAACLPV LAIGTPLEWE FAITLKSKIL FVDEFWRTLA
60 70 80 90 100
SAAHEFDELS ALTFDETEEL IYFNDQQHRN GSIFSLRRDA LMASHIAEQA
110 120 130 140 150
IQRTGNESVG GLAYDPLNRN LFWSDTLQKK IFFASIDSKV TETPKVLVDL
160 170 180 190 200
SQEGARPDGV AVDVCRRKLY WTNSNITHPT VESIDLAGTN RQVIIDTDID
210 220 230 240 250
MPRGIVVDQL SDRIFWIDDL KGVFFALKSA RLDGSDRQLV LHDKHHEPLN
260 270 280 290 300
LAVTNDAIYW TDKTTKAVWS HPKVPIVKAT TTTSPVKAEE EDATETIPDI
310 320 330 340 350
EPEPVAEVSA LLRVANLSEE ARGIVARTGF YQRLQKDEHC ANIVRKVKER
360 370 380 390 400
LDLMTKKKQM RSLVDEKTAQ LERDHCLNGG TYIADRVLCI CPTGFKGSRC
410 420 430 440 450
EIRECHNFCV HGTCEISDRA YPKCYCQPGF SGERCEISKC SGLCLNGGHC
460 470 480 490 500
KLEDISEKPS CECPHNFAGE RCEQNSTEIC ALFCRLLKHE ADIYVPFGCH
510 520 530 540 550
DICEELAKDA SDKIAIPQYH HLEVCMTPSP WTSNVIIVLV LGIVSCFFLV
560 570 580 590 600
AVIVHGFRRL YKPKRPRIRK TFVVRKQART NSSGDTPLTN RPLATEQCEI
610 620 630 640
TIENCCNMNI CETPCFDPKL VEQTLAKSSN CKEDKKILIH NMDDDLY
Length:647
Mass (Da):72,914
Last modified:November 3, 2009 - v2
Checksum:i4607D0D5484CBFE5
GO

Sequence cautioni

The sequence EDW30132 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479202 Genomic DNA Translation: EDW30132.1 Sequence problems.
RefSeqiXP_002024684.1, XM_002024648.1

Genome annotation databases

GeneIDi6599578
KEGGidpe:Dper_GL22490

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479202 Genomic DNA Translation: EDW30132.1 Sequence problems.
RefSeqiXP_002024684.1, XM_002024648.1

3D structure databases

ProteinModelPortaliB4H1F5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4H1F5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6599578
KEGGidpe:Dper_GL22490

Organism-specific databases

FlyBaseiFBgn0160082 Dper\GL22490

Phylogenomic databases

OrthoDBiEOG091G0PM5

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00135 LY, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS51120 LDLRB, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCUE_DROPE
AccessioniPrimary (citable) accession number: B4H1F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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