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Protein

Zinc finger protein 76

Gene

Znf76

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene namesi
Name:Znf76
Synonyms:Zfp523
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306239 Zfp523

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003530971 – 568Zinc finger protein 76Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiB4F7E9
PeptideAtlasiB4F7E9
PRIDEiB4F7E9

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000595

Structurei

3D structure databases

SMRiB4F7E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 451Add BLAST12
Repeati62 – 732Add BLAST12
Repeati88 – 993Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 993 X 12 AA approximate repeatsAdd BLAST66

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiB4F7E9
KOiK20828
PhylomeDBiB4F7E9

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B4F7E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLGLQTVT LSDGTTAYVQ QAIKGEKLLE GQVIQLEDGT TAYIHQVTIQ
60 70 80 90 100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGY DPSALEAVQL EDGSTAYIHH
110 120 130 140 150
PVSVPPDSTI LAVQTEVGLE DLAAEEEEGF GADTVVALEQ YASKVLHDSP
160 170 180 190 200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRSYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPSPK
410 420 430 440 450
PTHIAYLSEV KEESSDIPTQ VAMVTEEDGA PQVALITQDG TQQVSLSPED
460 470 480 490 500
LQALGSAISV VTQHRSTTLT IPGHQEELAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ QTLEEVISVA
560
TSAMQQGAVT LETTESGC
Length:568
Mass (Da):61,647
Last modified:September 23, 2008 - v1
Checksum:iC451DFF75302EE8B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LNL6F1LNL6_RAT
Zinc finger protein 523
Zfp523
568Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168249 mRNA Translation: AAI68249.1
RefSeqiNP_001128227.1, NM_001134755.1
UniGeneiRn.13446

Genome annotation databases

GeneIDi361809
KEGGirno:361809
UCSCiRGD:1306239 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168249 mRNA Translation: AAI68249.1
RefSeqiNP_001128227.1, NM_001134755.1
UniGeneiRn.13446

3D structure databases

SMRiB4F7E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000595

Proteomic databases

PaxDbiB4F7E9
PeptideAtlasiB4F7E9
PRIDEiB4F7E9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361809
KEGGirno:361809
UCSCiRGD:1306239 rat

Organism-specific databases

CTDi224656
RGDi1306239 Zfp523

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiB4F7E9
KOiK20828
PhylomeDBiB4F7E9

Miscellaneous databases

PROiPR:B4F7E9

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF76_RAT
AccessioniPrimary (citable) accession number: B4F7E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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