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Entry version 72 (07 Oct 2020)
Sequence version 1 (23 Sep 2008)
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Protein

E3 ubiquitin-protein ligase TRIP12

Gene

trip12

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2023Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIP12 (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase TRIP12
Thyroid receptor-interacting protein 12
Short name:
TR-interacting protein 12
Short name:
TRIP-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trip12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6071044, trip12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004196921 – 2056E3 ubiquitin-protein ligase TRIP12Add BLAST2056

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B4F6W9

PRoteomics IDEntifications database

More...
PRIDEi
B4F6W9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B4F6W9, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000063204

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini791 – 905WWEPROSITE-ProRule annotationAdd BLAST115
Domaini1949 – 2056HECTPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1560 – 1634K-boxBy similarityAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0168, Eukaryota
KOG0170, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156517

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B4F6W9

KEGG Orthology (KO)

More...
KOi
K10590

Database of Orthologous Groups

More...
OrthoDBi
34110at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632, HECT, 1 hit
PF02825, WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00678, WWE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: B4F6W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRPNNNPG GSLRRSQRNT AGAQPQEDTA GGRSNLEQAE NKTHSLPESR
60 70 80 90 100
KSHFKTPKVQ SNTTSGPSKG HSSKRGCSSS NLLPNPEDTE RINTTDTQRP
110 120 130 140 150
KKDHVRGVKR SASPDHSRTN SPSSAKKPKA LQHPEPSSGP RRPNNKPKKR
160 170 180 190 200
QGSQEQPFPS ASLPSTSKAH SRKGGSQGTS PLPKRKRTEL SPCVKSSSAA
210 220 230 240 250
VISTGAEDRP PKLSKLASKS ATSAKAGCSN ITDSSSSAST SSSSSAVASV
260 270 280 290 300
SAAPPGARVK QGKDQNKARR SRSASSPSPR RSSREKEQTK TSSSSKFDWA
310 320 330 340 350
ARFSPKVSLP KTKLSLPGSS KTETSKPGPS GLQAKLANLR KSTKKRSESP
360 370 380 390 400
PAELPSLRRS TRQKTTGSCA STSRRGSGLG KRAAAEARRQ EKMADPDNQE
410 420 430 440 450
GANSSAARTD ETAQGAAASS SVAGAVGMTT SGESESDDSE MGRLQALLEA
460 470 480 490 500
RGLPPHLFGP LGPRMSQLFH RTIGSGASSK AQQLLQGLQA TDESQQLQAV
510 520 530 540 550
IEMCQLLVMG NEETLGGFPV KSVVPALITL LQMEHNFDIM NHACRALTYM
560 570 580 590 600
MEALPRSSAV VVDAIPVFLE KLQVIQCIDV AEQALTALEM LSRRHSKAIL
610 620 630 640 650
QAGGLADCLL YLEFFSINAQ RNALAIAANC CQSISPDEFH FVADSLPLLT
660 670 680 690 700
QRLTHQDKKS VESTCLCFAR LVDNFQHEEN LLQQVASRDL LTNIQQLLVV
710 720 730 740 750
TPPILSSGMF IMVVRMFSLM CSNCPTLAVQ LMKQNIAETL HFLLCGASNG
760 770 780 790 800
SCLEQIDLVP RSPQELYELT SLICELMPCL PKEGIFAVDT MLKKGNAQNT
810 820 830 840 850
DGAIWQWRDD RGLWHPYSRI DSRIIEAAHQ VGEDEISLST LGRVYTIDFN
860 870 880 890 900
SMQQINEDTG TARAIQRKPN PVANANTTGH SELKRDDARA QLMKEDPELA
910 920 930 940 950
KSFIKTLFGV LYEVYSSSAG PAVRHKCLRA ILRIIYFADA ELLKDVLKNH
960 970 980 990 1000
AVSSHIASML SSQDLKIVVG ALQMAEILMQ KLPDIFSVYF RREGVMHQVK
1010 1020 1030 1040 1050
NLAESEALLT SPPKVCTNGS GSLASTTTIS TGSGTASGNS AADLGSPSLQ
1060 1070 1080 1090 1100
HRDDSLDLSP PGRLSDVLKR KRLPKRGPRR PKYSPPRDED KVDNQAKSPT
1110 1120 1130 1140 1150
TTQSPKSFLA SLNPKTWGRL STQSNSNNIE PARTAGVSGL ARAASKDTIS
1160 1170 1180 1190 1200
NNRERIRGWI KEQAHKFVER YFSSENMDGS NPALNVLQRL CNATEQLNLQ
1210 1220 1230 1240 1250
VDGGVECLVE IRSIVSESDV SSFEIQHSGF VKQLLLYLTS KSDKDIVSRD
1260 1270 1280 1290 1300
IRLKRFLHVF FGTPLPGEEP LAKLDPTENR HLLALVHKMN NCLSQMEQFP
1310 1320 1330 1340 1350
VKVHDFPSGN GTGSRGSQAL KFFNTHQLKC QLQRHPDCTN VKQWKGGPVK
1360 1370 1380 1390 1400
IDPLALVQAI ERYLVVRGYG RVREDDEDSD DDGSDEEIDE SLAAQFLNSG
1410 1420 1430 1440 1450
NVRHRLQFYI GDHLLPYNMT VYQAVRQYSI QTEEERESTD DESNPLGRAG
1460 1470 1480 1490 1500
IWTKTHTIWY KPVREEEESA KDTVGGKRGR AQTAPTKTSP RNSKKHDELW
1510 1520 1530 1540 1550
HGKDGVCPRI LNPLEVYLIS GPPENITFDD PSLDVVILLR VLHAISRYWY
1560 1570 1580 1590 1600
YLYDNAVCKE IIPTSEFNNS KLTAKANRQL QDPLVIMTGN IPTWLTELGK
1610 1620 1630 1640 1650
SCPFFFPFDT RQMLFYVTAF DRDRAMQRLL DTNPEINQSD SQDSRVAPRL
1660 1670 1680 1690 1700
DRKKRTVNRE DLLKQAESVM QDLGSSRAML EIQYENEVGT GLGPTLEFYA
1710 1720 1730 1740 1750
LVSQELQRAD LGLWRGEEVT LPNPKGSQEG TKYIHNLQGL FALPFGRTAK
1760 1770 1780 1790 1800
PAHIAKVKMK FRFLGKLMAK AIMDFRLVDI PLGLPFYKWM LRQESSLATH
1810 1820 1830 1840 1850
DLVNIDPVVA KSVYHLEDIV RQKKRLEQDK AQTKESLQFA LESLNMNGCS
1860 1870 1880 1890 1900
VEDLGLDFTL PGFPNIELKK GGKDVPVTIH NLEDYVRLVI YWALNEGVSR
1910 1920 1930 1940 1950
QLDSFRDGFE SVFPLNHLQY FYPEELDQLL CGSRADPWDV KTLMECCRPD
1960 1970 1980 1990 2000
HGYTHDSRAV KFLFEILSSF DKEQQRLFLQ FVTGSPRLPV GGFRSLNPPL
2010 2020 2030 2040 2050
TIVRKTFEAT ENPDDFLPSV MTCVNYLKLP DYSSIDNMRE KLLMAAREGQ

QSFHLS
Length:2,056
Mass (Da):227,673
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FE6E01AE1F48D57
GO
Isoform 2 (identifier: B4F6W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-74: Missing.

Show »
Length:2,014
Mass (Da):223,057
Checksum:iE9F7007933186669
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI66201 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04433333 – 74Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01022090 Genomic DNA No translation available.
AAMC01022091 Genomic DNA No translation available.
AAMC01022092 Genomic DNA No translation available.
AAMC01022093 Genomic DNA No translation available.
AAMC01022094 Genomic DNA No translation available.
AAMC01022095 Genomic DNA No translation available.
AAMC01022096 Genomic DNA No translation available.
BC168042 mRNA Translation: AAI68042.1
BC166201 mRNA Translation: AAI66201.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001136384.1, NM_001142912.1 [B4F6W9-1]
XP_012825572.1, XM_012970118.2 [B4F6W9-1]
XP_012825576.1, XM_012970122.2 [B4F6W9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000085319; ENSXETP00000089852; ENSXETG00000014757 [B4F6W9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100158539

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100158539

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01022090 Genomic DNA No translation available.
AAMC01022091 Genomic DNA No translation available.
AAMC01022092 Genomic DNA No translation available.
AAMC01022093 Genomic DNA No translation available.
AAMC01022094 Genomic DNA No translation available.
AAMC01022095 Genomic DNA No translation available.
AAMC01022096 Genomic DNA No translation available.
BC168042 mRNA Translation: AAI68042.1
BC166201 mRNA Translation: AAI66201.1 Sequence problems.
RefSeqiNP_001136384.1, NM_001142912.1 [B4F6W9-1]
XP_012825572.1, XM_012970118.2 [B4F6W9-1]
XP_012825576.1, XM_012970122.2 [B4F6W9-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000063204

Proteomic databases

PaxDbiB4F6W9
PRIDEiB4F6W9

Genome annotation databases

EnsembliENSXETT00000085319; ENSXETP00000089852; ENSXETG00000014757 [B4F6W9-1]
GeneIDi100158539
KEGGixtr:100158539

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9320
XenbaseiXB-GENE-6071044, trip12

Phylogenomic databases

eggNOGiKOG0168, Eukaryota
KOG0170, Eukaryota
GeneTreeiENSGT00940000156517
InParanoidiB4F6W9
KOiK10590
OrthoDBi34110at2759

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-XTR-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

ExpressionAtlasiB4F6W9, baseline

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF00632, HECT, 1 hit
PF02825, WWE, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00678, WWE, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50918, WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIPC_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4F6W9
Secondary accession number(s): B2GUA6, F7CNG9, F7D1U0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: September 23, 2008
Last modified: October 7, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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