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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27SubstrateUniRule annotation1
Active sitei80NucleophileUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei329SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciPMIR529507:G1GJY-2327-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:PMI2240
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001368441 – 350tRNA pseudouridine synthase DAdd BLAST350

Proteomic databases

PRIDEiB4F225

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2240

Structurei

3D structure databases

ProteinModelPortaliB4F225
SMRiB4F225
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 303TRUDUniRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
KOiK06176
OMAiGNRFFMR
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

B4F225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLPELHWL HGKPTATGRL KSTPEDFKVS EDLGFTLDGE GEHVMVRVRK
60 70 80 90 100
TGCNTAFVAE KLAKFAGIHP RDASYAGLKD RNAVTEQWFC LRMPGKEMPD
110 120 130 140 150
FSQFTLEGCE ILTTTRQQRK LRIGTLKGNH FTLVLRDISD VTSVETRLVE
160 170 180 190 200
IQKQGVPNYF GVQRFGRNGD NLRQAWRWAT NEIRVKERSK RSFYLSAARS
210 220 230 240 250
AMFNHLVSQR LERHIYTQVL CGDAMQLHGK RSWFVAEGAE LAQIQTRYEE
260 270 280 290 300
HDIHITAPLP GKGDLGTQAQ ALIFETDNLA DYEALWSLAQ QERVDTTRRA
310 320 330 340 350
INLLPENMSW HWLDDTTVSL SFFLPAGSFA TSVVRELILL GNIDAENISE
Length:350
Mass (Da):39,767
Last modified:September 23, 2008 - v1
Checksum:i1B2DBDC452A59330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA Translation: CAR44449.1
RefSeqiWP_012368295.1, NC_010554.1

Genome annotation databases

EnsemblBacteriaiCAR44449; CAR44449; PMI2240
GeneIDi6801955
KEGGipmr:PMI2240
PATRICifig|529507.6.peg.2187

Similar proteinsi

Entry informationi

Entry nameiTRUD_PROMH
AccessioniPrimary (citable) accession number: B4F225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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