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UniProtKB - B4EYY4 (MDTG_PROMH)
Protein
Multidrug resistance protein MdtG
Gene
mdtG
Organism
Proteus mirabilis (strain HI4320)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtGUniRule annotation |
Gene namesi | Name:mdtGUniRule annotation Ordered Locus Names:PMI1687 |
Organismi | Proteus mirabilis (strain HI4320) |
Taxonomic identifieri | 529507 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Morganellaceae › Proteus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 113 – 133 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 219 – 239 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 254 – 274 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 318 – 338 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 376 – 396 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000414581 | 1 – 402 | Multidrug resistance protein MdtGAdd BLAST | 402 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_57_3_6 |
OMAi | VCNSYSN |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
HAMAPi | MF_01528, MFS_MdtG, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023692, Mutidrug-R_MdtG IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
B4EYY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLKPRNNSW KQNLYIVWFG CFLTGAGFSL IMPFLPLYVE ELGIKDHESL
60 70 80 90 100
NLWTGVAFSI TFLFSAIAAP FWGKLSDRKG RKLMLLRSAL GMAIVMVLIG
110 120 130 140 150
FAQNIWQLLI LRALLGVLGG FVPNANALIA TQVPVKKSGW ALGTLSTGAV
160 170 180 190 200
SGALIGPLIG GILADLYGLR PVFFITAAVL FICFIVTLFF VSENFTPVSK
210 220 230 240 250
KDALSTQQVF SSLKNKRLVI CLFFTTMIIQ VATGSVTPIL TLYIRDLAGS
260 270 280 290 300
ISNLAFISGV IASVPGIAAL ISAPRFGKLG DRIGPDKVLI FTLGLSIFML
310 320 330 340 350
IPMALVSNYW ELGALRFLLG AVNAAMLPAV QTLILYNITP AIAGRIFSYN
360 370 380 390 400
QALRDVGNVT GPLMGAFVAA NYGFRAVFYF TAAVVFFNLI YSWISFRTPQ
RK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM942759 Genomic DNA Translation: CAR43519.1 |
RefSeqi | WP_012368071.1, NC_010554.1 |
Genome annotation databases
EnsemblBacteriai | CAR43519; CAR43519; PMI1687 |
GeneIDi | 6801162 |
KEGGi | pmr:PMI1687 |
PATRICi | fig|529507.6.peg.1638 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM942759 Genomic DNA Translation: CAR43519.1 |
RefSeqi | WP_012368071.1, NC_010554.1 |
3D structure databases
SMRi | B4EYY4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 529507.PMI1687 |
Genome annotation databases
EnsemblBacteriai | CAR43519; CAR43519; PMI1687 |
GeneIDi | 6801162 |
KEGGi | pmr:PMI1687 |
PATRICi | fig|529507.6.peg.1638 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_57_3_6 |
OMAi | VCNSYSN |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
HAMAPi | MF_01528, MFS_MdtG, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023692, Mutidrug-R_MdtG IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTG_PROMH | |
Accessioni | B4EYY4Primary (citable) accession number: B4EYY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 14, 2011 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 23, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families