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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:PMI1357
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000989091 – 486Cardiolipin synthase AAdd BLAST486

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI1357

Structurei

3D structure databases

ProteinModelPortaliB4EWI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

B4EWI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTFYTVLSW LTFFFYWLLI AGVTFRVLMH RRPVTSTMTW LLIIYILPLV
60 70 80 90 100
GVIAYFAFGE LHLGKRRVEH ARQMWPSVVA WLEELKKCKH IFAKHYSDVA
110 120 130 140 150
EPIFQLTAKR QGINGVKGNK IQLLTTCEDS LNAITRDINN ARDNIEMVFY
160 170 180 190 200
IWQSGGLVEE VTEALIQAAK RGVKCRIMVD SAGSRSFFRT NGPARMRAAG
210 220 230 240 250
IEFVESLQVN LFRFFLRRMD LRQHRKIVLI DNYISYTGSM NMVDPRYFKQ
260 270 280 290 300
DAGVGQWIDI MVRMEGPVST TLGIIYAFDW EMETGERHLP PPPDNNIMPF
310 320 330 340 350
EQANGHTTQV IASGPGFPEE LIQQSLITAI YSARKELVMT TPYFVPSDDL
360 370 380 390 400
AHAISTAAMR GVDVSIIVPR SNDSFLVRWA SRAFFTEILE AGVKVFQFED
410 420 430 440 450
GLLHTKSVMV DGQLSMVGSV NLDMRSLWLN FEITVVIDDE CFASDLSIVQ
460 470 480
YDYIARSTQL TLDEWEKRPF MNRVLERLCY FFSPLL
Length:486
Mass (Da):55,752
Last modified:September 23, 2008 - v1
Checksum:iCCDB60E95AB11863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA Translation: CAR42873.1
RefSeqiWP_004248139.1, NC_010554.1

Genome annotation databases

EnsemblBacteriaiCAR42873; CAR42873; PMI1357
GeneIDi6802116
KEGGipmr:PMI1357

Similar proteinsi

Entry informationi

Entry nameiCLSA_PROMH
AccessioniPrimary (citable) accession number: B4EWI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: July 18, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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