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Entry version 58 (10 Feb 2021)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

Type III secretion system protein

Gene

bcscV

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BCEN216591:G1G1V-6120-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Type III secretion system proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bcscVImported
ORF Names:BCAM2057Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri216591 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001035 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 53HelicalSequence analysisAdd BLAST19
Transmembranei59 – 78HelicalSequence analysisAdd BLAST20
Transmembranei90 – 111HelicalSequence analysisAdd BLAST22
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Transmembranei218 – 239HelicalSequence analysisAdd BLAST22
Transmembranei259 – 280HelicalSequence analysisAdd BLAST22
Transmembranei301 – 317HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneARBA annotation, Cell membrane, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
216591.BCAM2057

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni716 – 735DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili179 – 206Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG4789, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015346_3_0_4

Identification of Orthologs from Complete Genome Data

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OMAi
VNFIVIS

Database of Orthologous Groups

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OrthoDBi
436367at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.490.80, 1 hit
1.10.8.540, 1 hit
3.40.30.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042194, FHIPEP_1
IPR042193, FHIPEP_3
IPR042196, FHIPEP_4
IPR025505, FHIPEP_CS
IPR001712, T3SS_FHIPEP
IPR006302, T3SS_HrcV

The PANTHER Classification System

More...
PANTHERi
PTHR30161, PTHR30161, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00771, FHIPEP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005419, FlhA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00949, TYPE3IMAPROT

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01399, hrcV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00994, FHIPEP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4EFC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPKALPRD WQRLFSAGRG VSGRRLGGAS PRADLFLATF IVAVVALFIL
60 70 80 90 100
PLPQAALDGM ISLNLAASVV LLTVSTYVPS AVSFSSFPAL LLFTTLFRLA
110 120 130 140 150
LNIASCKLIL LHANAGHVID AFGRLVVGNN VVVGGVVFLV IAVVQFIVIA
160 170 180 190 200
KGSERVAEVG ARFSLDAMPG KQMSIDADLR AGIISADEAR ERREKLEQES
210 220 230 240 250
QMHGAMDGAM KFVKGDAIAG LVIAFINIVA GIAVGTLMHG MDIGEALQRY
260 270 280 290 300
AILTVGDGMA SQIPSLLVSI AAGIVTTRVA TRDARQRQLG EQLGEQLGAH
310 320 330 340 350
PRALLIAAFV LSGFLVVPGF PKWSFALIAL GLGAFAFSQL KRKTSAPSFN
360 370 380 390 400
LIHVAGRVGA ADDGQPAKVS HAAGVTSLIA VSLSDDLRTN LNLAQLQAAL
410 420 430 440 450
SSAKARVDAD IGTVFPRITL NDDEGAPAGT YRIYLQDVLV AHGALKPGWL
460 470 480 490 500
LWDGVAPLPE RAERQPAEAF GPFATALWIK PDGAAPDGKW LSSESALAAH
510 520 530 540 550
VEQIVRQHAD ELLGIQETQA LVHLVRRDHP ELVGELTRLV PLQRVTEVLR
560 570 580 590 600
RLLAEQVPIR NLRVIFESLI TWAPNEPDDV IALVELVRVD LRRMITDRHA
610 620 630 640 650
GTARQLRVVL FEQNLQERIE SAVMRTKQGN FLALSSAVKQ DIGEQVRAIV
660 670 680 690 700
QAAQAAGPGG HGNAQGGARL AVMVALGARR YVKTILQPVL PELAVLSYQE
710 720 730
VEEDVQLHTV GWVKNPPDDG TVGAGADVRA PGAVQ
Length:735
Mass (Da):78,356
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF257FCA0E9C0BCB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AM747721 Genomic DNA Translation: CAR55916.1

NCBI Reference Sequences

More...
RefSeqi
WP_006487865.1, NC_011001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAR55916; CAR55916; BCAM2057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bcj:BCAM2057

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747721 Genomic DNA Translation: CAR55916.1
RefSeqiWP_006487865.1, NC_011001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi216591.BCAM2057

Genome annotation databases

EnsemblBacteriaiCAR55916; CAR55916; BCAM2057
KEGGibcj:BCAM2057

Phylogenomic databases

eggNOGiCOG4789, Bacteria
HOGENOMiCLU_015346_3_0_4
OMAiVNFIVIS
OrthoDBi436367at2

Enzyme and pathway databases

BioCyciBCEN216591:G1G1V-6120-MONOMER

Family and domain databases

Gene3Di1.10.490.80, 1 hit
1.10.8.540, 1 hit
3.40.30.60, 1 hit
InterProiView protein in InterPro
IPR042194, FHIPEP_1
IPR042193, FHIPEP_3
IPR042196, FHIPEP_4
IPR025505, FHIPEP_CS
IPR001712, T3SS_FHIPEP
IPR006302, T3SS_HrcV
PANTHERiPTHR30161, PTHR30161, 1 hit
PfamiView protein in Pfam
PF00771, FHIPEP, 1 hit
PIRSFiPIRSF005419, FlhA, 1 hit
PRINTSiPR00949, TYPE3IMAPROT
TIGRFAMsiTIGR01399, hrcV, 1 hit
PROSITEiView protein in PROSITE
PS00994, FHIPEP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4EFC6_BURCJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4EFC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 10, 2021
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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