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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateUniRule annotation1
Sitei78Transition state stabilizerUniRule annotation1
Binding sitei160SubstrateUniRule annotation1
Binding sitei215SubstrateUniRule annotation1
Binding sitei333SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:BceJ2315_00400
ORF Names:BCAL0040
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000999761 – 364Uroporphyrinogen decarboxylaseAdd BLAST364

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi216591.BCAL0040

Structurei

3D structure databases

SMRiB4EEZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 32Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFZ Bacteria
COG0407 LUCA
HOGENOMiHOG000253896
KOiK01599
OMAiSWAGQLS
OrthoDBiPOG091H040E

Family and domain databases

CDDicd00717 URO-D, 1 hit
Gene3Di3.20.20.210, 1 hit
HAMAPiMF_00218 URO_D, 1 hit
InterProiView protein in InterPro
IPR038071 UROD/MetE-like_sf
IPR006361 Uroporphyrinogen_deCO2ase_HemE
IPR000257 Uroporphyrinogen_deCOase
PfamiView protein in Pfam
PF01208 URO-D, 1 hit
SUPFAMiSSF51726 SSF51726, 1 hit
TIGRFAMsiTIGR01464 hemE, 1 hit
PROSITEiView protein in PROSITE
PS00906 UROD_1, 1 hit
PS00907 UROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4EEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHNLLNDTF LRALLREPTD YTPIWLMRQA GRYLPEYNAT RARAGSFLGL
60 70 80 90 100
AKNPDYATEV TLQPLERFPL DAAILFSDIL TIPDAMGLGL DFQVGEGPKF
110 120 130 140 150
AHPVRTEADV AKLAVPDIEA TLGYVTGAVR EIRRALTDAQ GRQRVPLIGF
160 170 180 190 200
SGSPWTLACY MVEGGGSDDF RTVKSMAYSR PDLMHRILDV NAQAVAAYLN
210 220 230 240 250
AQIEAGAQAV MIFDTWGGAL ADGAYQRFSL DYIRRVVSQL KREHDGERVP
260 270 280 290 300
VITFTKGGGL WLEEIAATGV DAVGLDWTVN LGAARERVAG RVALQGNLDP
310 320 330 340 350
TILFAPPAAV REQARAVLDS YGNHPGHVFN LGHGISQFTS PDHVAELVDE
360
VHTHSRAIRS GAAG
Length:364
Mass (Da):39,545
Last modified:September 23, 2008 - v1
Checksum:iEBBF97E54FC6B9CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA Translation: CAR50346.1

Genome annotation databases

EnsemblBacteriaiCAR50346; CAR50346; BCAL0040
KEGGibcj:BCAL0040

Similar proteinsi

Entry informationi

Entry nameiDCUP_BURCJ
AccessioniPrimary (citable) accession number: B4EEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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