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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS3

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei600For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmS3Imported
Synonyms:glmSUniRule annotation
ORF Names:BCAL1321Imported
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Imported
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi216591.BCAL1321

Structurei

3D structure databases

ProteinModelPortaliB4E5K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 224Glutamine amidotransferase type-2InterPro annotationAdd BLAST223
Domaini281 – 421SISInterPro annotationAdd BLAST141
Domaini454 – 595SISInterPro annotationAdd BLAST142

Phylogenomic databases

eggNOGiCOG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiGTSHYAG
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4E5K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGAVAQ RDIVPILIEG LRRLEYRGYD SCGVATVVNG QARRERSMSR
60 70 80 90 100
VADLDAHVRS AGLTGSTGIA HTRWATHGAP ATCNAHPIFS RDEIALVHNG
110 120 130 140 150
IIENHETLRK QLADEHYEFD GQTDTEVVAH LIHSKYRGDL LAAVRDATSQ
160 170 180 190 200
LHGAYAIAVF SKHEPQRLIG ARAGSPLVVG VKDGECYLAS DALALAGITD
210 220 230 240 250
RFIFLEEGDI VELTPGGVRV LDRSGAPIER AIQTVSSAQG VVELGPYRHF
260 270 280 290 300
MQKEIFEQPQ AVAATIPDAG LFDPAVFGPD AARAFEQIDN VLILACGTSH
310 320 330 340 350
YSGLTARRWL ETIARIPAQV EIASEYRYSD ALAMPNTLVV SVSQSGETAD
360 370 380 390 400
TLAALKYAQA LGHIDTLAIC NVPTSAMMRQ TGLRFLTRAG PEIGVASTKA
410 420 430 440 450
FTTQLVALFI LAVTLGRLRG YVDDAQLARY TTQLRRLPGA LEDVLGLEPQ
460 470 480 490 500
IERWAAEFSQ HENALFLGRG LHYPIALEGA LKLKEISYIH AEAYPAGELK
510 520 530 540 550
HGPLALVTHT MPVATIAPND ALLEKLKSNM QEVRARGGQL YVFADADTRI
560 570 580 590 600
DNGEGVSVLR MPDYYGLLSP ILHVVPLQLL AYHAACLRGA DIDKPRNLAK

SVTVE
Length:605
Mass (Da):65,521
Last modified:September 23, 2008 - v1
Checksum:iA4D40A5769BBECC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA Translation: CAR51619.1
RefSeqiWP_006490513.1, NC_011000.1

Genome annotation databases

EnsemblBacteriaiCAR51619; CAR51619; BCAL1321
KEGGibcj:BCAL1321

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA Translation: CAR51619.1
RefSeqiWP_006490513.1, NC_011000.1

3D structure databases

ProteinModelPortaliB4E5K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216591.BCAL1321

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR51619; CAR51619; BCAL1321
KEGGibcj:BCAL1321

Phylogenomic databases

eggNOGiCOG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiGTSHYAG
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB4E5K1_BURCJ
AccessioniPrimary (citable) accession number: B4E5K1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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