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Entry version 73 (10 Feb 2021)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ61597, highly similar to Fibrillin-1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ61597, highly similar to Fibrillin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500280116928 – 1149Sequence analysisAdd BLAST1122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi150 ↔ 160PROSITE-ProRule annotation
Disulfide bondi168 ↔ 177PROSITE-ProRule annotation
Disulfide bondi785 ↔ 795PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4E3I6

PRoteomics IDEntifications database

More...
PRIDEi
B4E3I6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 178EGF-likeInterPro annotationAdd BLAST33
Domaini184 – 216TBInterPro annotationAdd BLAST33
Domaini212 – 252EGF-likeInterPro annotationAdd BLAST41
Domaini253 – 291EGF-likeInterPro annotationAdd BLAST39
Domaini294 – 335EGF-likeInterPro annotationAdd BLAST42
Domaini336 – 372EGF-likeInterPro annotationAdd BLAST37
Domaini377 – 417EGF-likeInterPro annotationAdd BLAST41
Domaini422 – 479TBInterPro annotationAdd BLAST58
Domaini496 – 537EGF-likeInterPro annotationAdd BLAST42
Domaini538 – 574EGF-likeInterPro annotationAdd BLAST37
Domaini583 – 638TBInterPro annotationAdd BLAST56
Domaini656 – 697EGF-likeInterPro annotationAdd BLAST42
Domaini698 – 738EGF-likeInterPro annotationAdd BLAST41
Domaini739 – 776EGF-likeInterPro annotationAdd BLAST38
Domaini781 – 816EGF-likeInterPro annotationAdd BLAST36
Domaini820 – 862EGF-likeInterPro annotationAdd BLAST43
Domaini863 – 902EGF-likeInterPro annotationAdd BLAST40
Domaini903 – 944EGF-likeInterPro annotationAdd BLAST42
Domaini949 – 1001TBInterPro annotationAdd BLAST53
Domaini1017 – 1055EGF-likeInterPro annotationAdd BLAST39
Domaini1056 – 1095EGF-likeInterPro annotationAdd BLAST40
Domaini1096 – 1136EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR040872, Fibrillin_U_N
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 17 hits
PF18193, Fibrillin_U_N, 1 hit
PF00683, TB, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 20 hits
SM00179, EGF_CA, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 4 hits
SSF57581, SSF57581, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 17 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 12 hits
PS50026, EGF_3, 18 hits
PS01187, EGF_CA, 7 hits
PS51364, TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B4E3I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGRLLEIA LGFTVLLASY TSHGADANLE AGNVKETRAS RAKRRGGGGH
60 70 80 90 100
DALKGPNVCG SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC
110 120 130 140 150
TCPSGQIAPS CGSRSIQHCN IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC
160 170 180 190 200
ESGCLNGGRC VAPNRCACTY GFTGPQCERD YRTGPCFTVI SNQMCQGQLS
210 220 230 240 250
GIVCTKTLCC TDINECEIGA HNCGKHAVCT NTAGSFKCSC SPGWIGDGIK
260 270 280 290 300
CTDLDECSNG THMCSQHADC KNTMGSYRCL CKEGYTGDGF TCTDLDECSE
310 320 330 340 350
NLNLCGNGQC LNAPGGYRCE CDMGFVPSAD GKACEDIDEC SLPNICVFGT
360 370 380 390 400
CHNLPGLFRC ECEIGYELDR SGGNCTDVNE CLDPTTCISG NCVNTPGSYI
410 420 430 440 450
CDCPPDFELN PTRVGCVDTR SGNCYLDIRP RGDNGDTACS NEIGVGVSKA
460 470 480 490 500
SCCCSLGKAW GTPCEMCPAV NTSEYKILCP GGEGFRPNPI TVILEDIDEC
510 520 530 540 550
QELPGLCQGG KCINTFGSFQ CRCPTGYYLN EDTRVCDDVN ECETPGICGP
560 570 580 590 600
GTCYNTVGNY TCICPPDYMQ VNGGNNCMDM RRSLCYRNYY ADNQTCDGEL
610 620 630 640 650
LFNMTKKMCC CSYNIGRAWN KPCEQCPIPS TDEFATLCGS QRPGFVIDIY
660 670 680 690 700
TGLPVDIDEC REIPGVCENG VCINMVGSFR CECPVGFFYN DKLLVCEDID
710 720 730 740 750
ECQNGPVCQR NAECINTAGS YRCDCKPGYR FTSTGQCNDR NECQEIPNIC
760 770 780 790 800
SHGQCIDTVG SFYCLCHTGF KTNDDQTMCL DINECERDAC GNGTCRNTIG
810 820 830 840 850
SFNCRCNHGF ILSHNNDCID VDECASGNGN LCRNGQCINT VGSFQCQCNE
860 870 880 890 900
GYEVAPDGRT CVDINECLLE PRKCAPGTCQ NLDGSYRCIC PPGYSLQNEK
910 920 930 940 950
CEDIDECVEE PEICALGTCS NTEGSFKCLC PEGFSLSSSG RRCQDLRMSY
960 970 980 990 1000
CYAKFEGGKC SSPKSRNHSK QECCCALKGE GWGDPCELCP TEPDEAFRQI
1010 1020 1030 1040 1050
CPYGSGIIVG PDDSAVDMDE CKEPDVCKHG QCINTDGSYR CECPFGYILA
1060 1070 1080 1090 1100
GNECVDTDEC SVGNPCGNGT CKNVIGGFEC TCEEGFEPGP MMTCEDINEC
1110 1120 1130 1140
AQNPLLCAFR CVNTYGSYEC KCPVGYVLRE DRRMCKDEDE CEEGKHDCT
Length:1,149
Mass (Da):124,381
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF01F8A9557815DE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1149Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK304737 mRNA Translation: BAG65498.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304737 mRNA Translation: BAG65498.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4E3I6
PRIDEiB4E3I6

Family and domain databases

Gene3Di3.90.290.10, 3 hits
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR040872, Fibrillin_U_N
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf
PfamiView protein in Pfam
PF07645, EGF_CA, 17 hits
PF18193, Fibrillin_U_N, 1 hit
PF00683, TB, 3 hits
SMARTiView protein in SMART
SM00181, EGF, 20 hits
SM00179, EGF_CA, 17 hits
SUPFAMiSSF57184, SSF57184, 4 hits
SSF57581, SSF57581, 3 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 17 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 12 hits
PS50026, EGF_3, 18 hits
PS01187, EGF_CA, 7 hits
PS51364, TB, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4E3I6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4E3I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 10, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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