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Entry version 66 (07 Apr 2021)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ56216, highly similar to Amyloid-like protein 2 (CDEIbox-binding protein) (CDEBP)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCopperARBA annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ56216, highly similar to Amyloid-like protein 2 (CDEIbox-binding protein) (CDEBP)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei620 – 642HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500280114926 – 689Sequence analysisAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 117PROSITE-ProRule annotation
Disulfide bondi143 ↔ 197PROSITE-ProRule annotation
Disulfide bondi154 ↔ 184PROSITE-ProRule annotation
Disulfide bondi168 ↔ 196PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4E3I5

PRoteomics IDEntifications database

More...
PRIDEi
B4E3I5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B4E3I5, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 199E1InterPro annotationAdd BLAST160
Domaini311 – 502E2InterPro annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 133GFLD subdomainPROSITE-ProRule annotationAdd BLAST94
Regioni141 – 199CuBD subdomainPROSITE-ProRule annotationAdd BLAST59
Regioni205 – 294DisorderedSequence analysisAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili369 – 389Sequence analysisAdd BLAST21
Coiled coili492 – 512Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 230AcidicSequence analysisAdd BLAST22
Compositional biasi239 – 264AcidicSequence analysisAdd BLAST26
Compositional biasi265 – 280PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APP family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCRSHIV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR011993, PH-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23103, PTHR23103, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00203, AMYLOIDA4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00006, A4_EXTRA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF89811, SSF89811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4E3I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAATGRLL LLLLVGLTAP ALALAGYIEA LAANAGTGFA VAEPQIAMFC
60 70 80 90 100
GKLNMHVNIQ TGKWEPDPTG TKSCFETKEE VLQYCQEMYP ELQITNVMEA
110 120 130 140 150
NQRVSIDNWC RRDKKQCKSR FVTPFKCLVG EFVSDVLLVP EKCQFFHKER
160 170 180 190 200
MEVCENHQHW HTVVKEACLT QGMTLYSYGM LLPCGVDQFH GTEYVCCPQT
210 220 230 240 250
KIIGSVSKEE EEEDEEEEEE EDEEEDYDVY KSEFPTEADL EDFTEAAVDE
260 270 280 290 300
DDEDEEEGEE VVEDRDYYYD TFKGDDYNEE NPTEPGSDGT MSDKEITHDV
310 320 330 340 350
KVPPTPLPTN DVDVYFETSA DDNEHARFQK AKEQLEIRHR NRMDRVKKEW
360 370 380 390 400
EEAELQAKNL PKAERQTLIQ HFQAMVKALE KEAASEKQQL VETHLARVEA
410 420 430 440 450
MLNDRRRMAL ENYLAALQSD PPRPHRILQA LRRYVRAENK DRLHTIRHYQ
460 470 480 490 500
HVLAVDPEKA AQMKSQVMTH LHVIEERRNQ SLSLLYKVPY VAQEIQEEID
510 520 530 540 550
ELLQEQRADM DQFTASISET PVDVRVSSEE SEEIPPFHPF HPFPALPENE
560 570 580 590 600
GSGVGEQDGG LIGAEEKVIN SKNKVDENMV IDETLDVKEM IFNAERVGGL
610 620 630 640 650
EEERESVGPL REDFSLSSSA LIGLLVIAVA IATVIVISLV MLRKRQYGTI
660 670 680
SHGIVEVDPM LTPEERHLNK MQNHGYENPT YKYLEQMQI
Length:689
Mass (Da):78,765
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAE94A167A8506E0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK304736 mRNA Translation: BAG65497.1

NCBI Reference Sequences

More...
RefSeqi
NP_001135749.1, NM_001142277.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
334

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304736 mRNA Translation: BAG65497.1
RefSeqiNP_001135749.1, NM_001142277.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4E3I5
PRIDEiB4E3I5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
334

Genome annotation databases

GeneIDi334

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
334
PharmGKBiPA24885

Phylogenomic databases

OMAiQCRSHIV

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
334, 7 hits in 1000 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
334

Gene expression databases

GenevisibleiB4E3I5, HS

Family and domain databases

Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
InterProiView protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR011993, PH-like_dom_sf
PANTHERiPTHR23103, PTHR23103, 2 hits
PfamiView protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit
PRINTSiPR00203, AMYLOIDA4
SMARTiView protein in SMART
SM00006, A4_EXTRA, 1 hit
SUPFAMiSSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF89811, SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4E3I5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4E3I5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 7, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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