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Entry version 54 (16 Jan 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ57017, highly similar to Atrial natriuteric peptide-converting enzyme

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ57017, highly similar to Atrial natriuteric peptide-converting enzymeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei46 – 69HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi216 ↔ 240PROSITE-ProRule annotation
Disulfide bondi277 ↔ 295PROSITE-ProRule annotation
Disulfide bondi289 ↔ 304PROSITE-ProRule annotation
Disulfide bondi306 ↔ 318PROSITE-ProRule annotation
Disulfide bondi313 ↔ 331PROSITE-ProRule annotation
Disulfide bondi325 ↔ 340PROSITE-ProRule annotation
Disulfide bondi350 ↔ 368PROSITE-ProRule annotation
Disulfide bondi362 ↔ 377PROSITE-ProRule annotation
Disulfide bondi465 ↔ 503PROSITE-ProRule annotation
Disulfide bondi492 ↔ 533PROSITE-ProRule annotation
Disulfide bondi496 ↔ 520PROSITE-ProRule annotation
Disulfide bondi543 ↔ 555PROSITE-ProRule annotation
Disulfide bondi550 ↔ 568PROSITE-ProRule annotation
Disulfide bondi562 ↔ 577PROSITE-ProRule annotation
Disulfide bondi600 ↔ 615PROSITE-ProRule annotation
Disulfide bondi618 ↔ 630PROSITE-ProRule annotation
Disulfide bondi625 ↔ 643PROSITE-ProRule annotation
Disulfide bondi637 ↔ 652PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4E2W9

PRoteomics IDEntifications database

More...
PRIDEi
B4E2W9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B4E2W9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 259FZInterPro annotationAdd BLAST126
Domaini413 – 536FZInterPro annotationAdd BLAST124

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051079

KEGG Orthology (KO)

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KOi
K09614

Database of Orthologous Groups

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OrthoDBi
1314811at2759

Family and domain databases

Conserved Domains Database

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CDDi
cd00112 LDLa, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 6 hits
SSF63501 SSF63501, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4E2W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV
60 70 80 90 100
LIPCICALVL LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN
110 120 130 140 150
TIYNQSTVVS TAHPDQHVPA WTTDASLPGD QSHRNTSACM NITHSQCQML
160 170 180 190 200
PYHATLTPLL SVVRNMEMEK FLKFFTYLHR LSCYQHIMLF GCTLAFPECI
210 220 230 240 250
IDGDDSHGLL PCRSFCEAAK EGCESVLGMV NYSWPDFLRC SQFRNQTESS
260 270 280 290 300
NVSRICFSPQ QENGKQLLCG RGENFLCASG ICIPGKLQCN GYNDCDDWSD
310 320 330 340 350
EAHCNCSENL FHCHTGKCLN YSLVCDGYDD CGDLSDEQNC ACHSQGLVEC
360 370 380 390 400
RNGQCIPSTF QCDGDEDCKD GSDEENCSVI QTSCQEGDQR CLYNPCLDSC
410 420 430 440 450
GGSSLCDPNN SLNNCSQCEP ITLELCMNLP YNSTSYPNYF GHRTQKEASI
460 470 480 490 500
SWESSLFPAL VQTNCYKYLM FFSCTILVPK CDVNTGEHIP PCRALCEHSK
510 520 530 540 550
ERCESVLGIV GLQWPEDTDC SQFPEENSDN QTCLMPDEYV EECSPSHFKC
560 570 580 590 600
RSGQCVLASR RCDGQADCDD DSDEENCGCK ERDLWECPSN KQCLKHTVIC
610 620 630 640 650
DGFPDCPDYM DEKNCSFCQD DELECANHAC VSRDLWCDGE ADCSDSSDEW
660 670 680 690 700
DCGELLVSAI CCTLSCLSAT EAEWILNYFL YFTDQVHLFC FTVIKADSAD
710 720 730
LCVLFPTHRK FPHEATSLFE ISILYGKTFG FKML
Length:734
Mass (Da):81,882
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1A51E329D885E97
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK304466 mRNA Translation: BAG65281.1

NCBI Reference Sequences

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RefSeqi
NP_001265514.1, NM_001278585.1
NP_001265515.1, NM_001278586.1
NP_006578.2, NM_006587.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.518618
Hs.604887

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
10699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10699

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304466 mRNA Translation: BAG65281.1
RefSeqiNP_001265514.1, NM_001278585.1
NP_001265515.1, NM_001278586.1
NP_006578.2, NM_006587.3
UniGeneiHs.518618
Hs.604887

3D structure databases

ProteinModelPortaliB4E2W9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB4E2W9
PRIDEiB4E2W9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10699
KEGGihsa:10699

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10699

Phylogenomic databases

HOVERGENiHBG051079
KOiK09614
OrthoDBi1314811at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10699

Family and domain databases

CDDicd00112 LDLa, 6 hits
Gene3Di1.10.2000.10, 2 hits
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 6 hits
SUPFAMiSSF57424 SSF57424, 6 hits
SSF63501 SSF63501, 2 hits
PROSITEiView protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4E2W9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4E2W9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 16, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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