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Protein
Submitted name:

cDNA FLJ58227, highly similar to Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2)

Gene

GCLC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ58227, highly similar to Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2)Imported
Gene namesi
Name:GCLCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000001084.10
HGNCiHGNC:4311 GCLC

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000001084

PTM / Processingi

Proteomic databases

PeptideAtlasiB4E2I4
PRIDEiB4E2I4

Expressioni

Gene expression databases

BgeeiENSG00000001084

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3754 Eukaryota
ENOG410XQIG LUCA
GeneTreeiENSGT00390000011908
HOVERGENiHBG005924

Family and domain databases

InterProiView protein in InterPro
IPR004308 GCS
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11164 PTHR11164, 1 hit
PfamiView protein in Pfam
PF03074 GCS, 1 hit
SUPFAMiSSF55931 SSF55931, 3 hits

Sequencei

Sequence statusi: Complete.

B4E2I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSFDHENK KVRLVLSGEK VLETLQEKGE RTNPNHPTLW RPEYGSYMIE
60 70 80 90 100
GTPGQPYGGT MSEFNTVEAN MRKRRKEATS ILEENQALCT ITSFPRLGCP
110 120 130 140 150
GFTLPEVKPN PVEGGASKSL FFPDEAINKH PRFSTLTRNI RHRRGEKVVI
160 170 180 190 200
NVPIFKDKNT PSPFIETFTE DDEASRASKP DHIYMDAMGF GMGNCCLQVT
210 220 230 240 250
FQACSISEAR YLYDQLATIC PIVMALSAAS PFYRGYVSDI DCRWGVISAS
260 270 280 290 300
VDDRTREERG LEPLKNNNYR ISKSRYDSID SYLSKCGEKY NDIDLTIDKE
310 320 330 340 350
IYEQLLQEGI DHLLAQHVAH LFIRDPLTLF EEKIHLDDAN ESDHFENIQS
360 370 380 390 400
TNWQTMRFKP PPPNSDIGWR VEFRPMEVQL TDFENSAYVV FVVLLTRVIL
410 420 430 440 450
SYKLDFLIPL SKVDENMKVA QKRDAVLQGM FYFRKDICKG GNAVVDGCGK
460 470 480 490 500
AQNSTELAAE EYTLMSIDTI INGKEGVFPG LIPILNSYLE NMEVDVDTRC
510 520 530 540 550
SILNYLKLIK KRASGELMTV ARWMREFIAN HPDYKQDSVI TDEMNYSLIL
560 570 580
KCNQIANELC ECPELLGSAF RKVKYSGSKT DSSN
Length:584
Mass (Da):66,464
Last modified:September 23, 2008 - v1
Checksum:i1788ED4325E8127B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033397 Genomic DNA No translation available.
AK304288 mRNA Translation: BAG65146.1
RefSeqiNP_001184044.1, NM_001197115.1
UniGeneiHs.654465

Genome annotation databases

EnsembliENST00000616923; ENSP00000482756; ENSG00000001084
GeneIDi2729
UCSCiuc021zau.3 human

Similar proteinsi

Entry informationi

Entry nameiB4E2I4_HUMAN
AccessioniPrimary (citable) accession number: B4E2I4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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