UniProtKB - B4E1C1 (B4E1C1_HUMAN)
Protein
Daxx
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
Keywordsi
Molecular function | ChaperoneARBA annotation, Chromatin regulatorARBA annotation, RepressorARBA annotation |
Biological process | ApoptosisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: DaxxARBA annotationAlternative name(s): Death domain-associated protein 6ARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Nucleus
- PML body ARBA annotation
- nucleolus ARBA annotation
- nucleoplasm ARBA annotation
Other locations
- centromere ARBA annotation
Nucleus
Other locations
- chromosome, centromeric region Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CentromereARBA annotation, ChromosomeARBA annotation, CytoplasmARBA annotation, NucleusARBA annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationProteomic databases
MaxQBi | B4E1C1 |
PeptideAtlasi | B4E1C1 |
PRIDEi | B4E1C1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 157 | DaxxInterPro annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 67 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 159 – 197 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 396 – 736 | DisorderedSequence analysisAdd BLAST | 341 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 200 – 220 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 159 – 196 | PolarSequence analysisAdd BLAST | 38 | |
Compositional biasi | 446 – 499 | AcidicSequence analysisAdd BLAST | 54 | |
Compositional biasi | 508 – 541 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 592 – 631 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 689 – 736 | PolarSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the DAXX family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
OMAi | AMMQDKS |
OrthoDBi | 557255at2759 |
Family and domain databases
CDDi | cd13151, DAXX_helical_bundle, 1 hit |
Gene3Di | 1.10.8.810, 1 hit |
InterProi | View protein in InterPro IPR005012, Daxx IPR031333, Daxx_N IPR038298, Daxx_N_sf |
PANTHERi | PTHR12766:SF7, PTHR12766:SF7, 1 hit |
Pfami | View protein in Pfam PF03344, Daxx, 1 hit |
i Sequence
Sequence statusi: Complete.
B4E1C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGSENCGEG RLERRFLSII VLDDDDEDEA AAQPGPSHPL PNAASPGAEA
60 70 80 90 100
PSSSEPHGAR GSSSSGGKKC YKLENEKLFE EFLELCKMQT ADHPEVVPFL
110 120 130 140 150
YNRQQRAHSL FLASAEFCNI LSRVLSRARS RPAKLYVYIN ELCTVLKAHS
160 170 180 190 200
AKKKLNLAPA ATTSNEPSGN NPPTHLSLDP TNAENTASQS PRTRGSRRQI
210 220 230 240 250
QRLEQLLALY VAEIRRLQEK ELDLSELDDP DSAYLQEARL KRKLIRLFGR
260 270 280 290 300
LCELKDCSSL TGRVIEQRIP YRGTRYPEVN RRIERLINKP GPDTFPDYGD
310 320 330 340 350
VLRAVEKAAA RHSLGLPRQQ LQLMAQDAFR DVGIRLQERR HLDLIYNFGC
360 370 380 390 400
HLTDDYRPGV DPALSDPVLA RRLRENRSLA MSRLDEVISK YAMLQDKSEE
410 420 430 440 450
GERKKRRARL QGTSSHSADT PEASLDSGEG PSGMASQGCP SASRAETDDE
460 470 480 490 500
DDEESDEEEE EEEEEEEEEA TDSEEEEDLE QMQEGQEDDE EEDEEEEAAA
510 520 530 540 550
GKDGDKSPMS SLQISNEKNL EPGKQISRSS GEQQNKGRIV SPSLLSEEPL
560 570 580 590 600
APSSIDAESN GEQPEELTLE EESPVSQLFE LEIEALPLDT PSSVETDISS
610 620 630 640 650
SRKQSEEPFT TVLENGAGMV SSTSFNGGVS PHNWGDSGPP CKKSRKEKKQ
660 670 680 690 700
TGSGPLGNSY VERQRSVHEK NGKKICTLPS PPSPLASLAP VADSSTRVDS
710 720 730 740 750
PSHGLVTSSL CIPSPARLSQ TPHSQPPRPG TCKTSVATQC DPEEIIVLSD
SD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303767 mRNA Translation: BAG64733.1 |
RefSeqi | NP_001135442.1, NM_001141970.1 |
Genome annotation databases
GeneIDi | 1616 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303767 mRNA Translation: BAG64733.1 |
RefSeqi | NP_001135442.1, NM_001141970.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4E1C1 |
PeptideAtlasi | B4E1C1 |
PRIDEi | B4E1C1 |
Protocols and materials databases
DNASUi | 1616 |
Genome annotation databases
GeneIDi | 1616 |
Organism-specific databases
CTDi | 1616 |
PharmGKBi | PA27148 |
Phylogenomic databases
OMAi | AMMQDKS |
OrthoDBi | 557255at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1616, 110 hits in 995 CRISPR screens |
GenomeRNAii | 1616 |
Gene expression databases
Genevisiblei | B4E1C1, HS |
Family and domain databases
CDDi | cd13151, DAXX_helical_bundle, 1 hit |
Gene3Di | 1.10.8.810, 1 hit |
InterProi | View protein in InterPro IPR005012, Daxx IPR031333, Daxx_N IPR038298, Daxx_N_sf |
PANTHERi | PTHR12766:SF7, PTHR12766:SF7, 1 hit |
Pfami | View protein in Pfam PF03344, Daxx, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4E1C1_HUMAN | |
Accessioni | B4E1C1Primary (citable) accession number: B4E1C1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |