UniProtKB - B4E0T2 (B4E0T2_HUMAN)
Protein
PTS1-BP
Gene
PEX5
Organism
Homo sapiens (Human)
Status
Functioni
Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.ARBA annotation
GO - Biological processi
- cell development Source: Ensembl
- cerebral cortex cell migration Source: Ensembl
- cerebral cortex neuron differentiation Source: Ensembl
- endoplasmic reticulum organization Source: Ensembl
- fatty acid beta-oxidation Source: Ensembl
- mitochondrial membrane organization Source: Ensembl
- neuromuscular process Source: Ensembl
- neuron migration Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- protein import into peroxisome matrix Source: Ensembl
- very long-chain fatty acid metabolic process Source: Ensembl
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Recommended name: PTS1-BPARBA annotationAlternative name(s): Peroxin-5ARBA annotation Peroxisomal C-terminal targeting signal import receptorARBA annotation Peroxisomal targeting signal 1 receptorARBA annotation Peroxisome receptor 1ARBA annotation |
Gene namesi | Name:PEX5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9719, PEX5 |
VEuPathDBi | HostDB:ENSG00000139197.10 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Mitochondrion
- mitochondrion Source: GOC
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
PTM / Processingi
Keywords - PTMi
Thioester bondARBA annotationProteomic databases
MaxQBi | B4E0T2 |
PRIDEi | B4E0T2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139197, Expressed in medial globus pallidus and 243 other tissues |
ExpressionAtlasi | B4E0T2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 610 | TPR_REGIONInterPro annotationAdd BLAST | 255 | |
Repeati | 356 – 389 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 390 – 423 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 509 – 542 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 543 – 576 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 577 – 610 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 74 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the peroxisomal targeting signal receptor family.ARBA annotation
Keywords - Domaini
TPR repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156605 |
OMAi | QQHEMEQ |
OrthoDBi | 588648at2759 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024111, PEX5/PEX5L IPR024113, PEX5_animals IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit PTHR10130:SF2, PTHR10130:SF2, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
B4E0T2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLCRAHRVL GLRGARELAV TMAMRELVEA ECGGANPLMK LAGHFTQDKA
60 70 80 90 100
LRQEGLRPGP WPPGAPASEA ASKPLGVASE DELVAEFLQD QNAPLVSRAP
110 120 130 140 150
QTFKMDDLLA EMQQIEQSNF RQAPQRAPGV ADLALSENWA QEFLAAGDAV
160 170 180 190 200
DVTQDYNETD WSQEFISEVT DPLSVSPARW AEEYLEQSEE KLWLGEPEGT
210 220 230 240 250
ATDRWYDEYH PEEDLQHTAS DFVAKVDDPK LANSEFLKFV RQIGEGQVSL
260 270 280 290 300
ESGAGSGRAQ AEQWAAEFIQ QQGTSDAWVD QFTRPVNTSA LDMEFERAKS
310 320 330 340 350
AIESDVDFWD KLQAELEEMA KRDAEAHPWL SDYDDLTSAT YDKGYQFEEE
360 370 380 390 400
NPLRDHPQPF EEGLRRLQEG DLPNAVLLFE AAVQQDPKHM EAWQYLGTTQ
410 420 430 440 450
AENEQELLAI SALRRCLELK PDNQTALMAL AVSFTNESLQ RQACETLRDW
460 470 480 490 500
LRYTPAYAHL VTPAEEGAGG AGLGPSKRIL GSLLSDSLFL EVKELFLAAV
510 520 530 540 550
RLDPTSIDPD VQCGLGVLFN LSGEYDKAVD CFTAALSVRP NDYLLWNKLG
560 570 580 590 600
ATLANGNQSE EAVAAYRRAL ELQPGYIRSR YNLGISCINL GAHREAVEHF
610 620 630 640 650
LEALNMQRKS RGPRGEGGAM SENIWSTLRL ALSMLGQSDA YGAADARDLS
660
TLLTMFGLPQ
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP50542 | PEX5_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 PXR1 | 639 | Annotation score: | ||
J3KPV0 | J3KPV0_HUMAN | PTS1-BP | PEX5 | 410 | Annotation score: | ||
F5H3X7 | F5H3X7_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 248 | Annotation score: | ||
F5GZ41 | F5GZ41_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 115 | Annotation score: | ||
F5GYB4 | F5GYB4_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 128 | Annotation score: | ||
F5H5C0 | F5H5C0_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 272 | Annotation score: | ||
F5H0L9 | F5H0L9_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 118 | Annotation score: | ||
F5H205 | F5H205_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 114 | Annotation score: | ||
F5H637 | F5H637_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 168 | Annotation score: | ||
F5GXX3 | F5GXX3_HUMAN | Peroxisomal targeting signal 1 rece... | PEX5 | 104 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018653 Genomic DNA No translation available. AK303515 mRNA Translation: BAG64544.1 |
RefSeqi | NP_001287718.1, NM_001300789.1 |
Genome annotation databases
Ensembli | ENST00000412720; ENSP00000391601; ENSG00000139197 |
GeneIDi | 5830 |
UCSCi | uc010sgd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018653 Genomic DNA No translation available. AK303515 mRNA Translation: BAG64544.1 |
RefSeqi | NP_001287718.1, NM_001300789.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4E0T2 |
PRIDEi | B4E0T2 |
Protocols and materials databases
Antibodypediai | 22900, 268 antibodies |
DNASUi | 5830 |
Genome annotation databases
Ensembli | ENST00000412720; ENSP00000391601; ENSG00000139197 |
GeneIDi | 5830 |
UCSCi | uc010sgd.3, human |
Organism-specific databases
CTDi | 5830 |
HGNCi | HGNC:9719, PEX5 |
OpenTargetsi | ENSG00000139197 |
VEuPathDBi | HostDB:ENSG00000139197.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156605 |
OMAi | QQHEMEQ |
OrthoDBi | 588648at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5830, 54 hits in 1001 CRISPR screens |
ChiTaRSi | PEX5, human |
GenomeRNAii | 5830 |
Gene expression databases
Bgeei | ENSG00000139197, Expressed in medial globus pallidus and 243 other tissues |
ExpressionAtlasi | B4E0T2, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024111, PEX5/PEX5L IPR024113, PEX5_animals IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit PTHR10130:SF2, PTHR10130:SF2, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4E0T2_HUMAN | |
Accessioni | B4E0T2Primary (citable) accession number: B4E0T2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |