UniProtKB - B4DZK0 (B4DZK0_HUMAN)
Protein
Cysteine protease
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 191 | NucleophileUniRule annotation | 1 | |
Active sitei | 395 | UniRule annotation | 1 | |
Active sitei | 397 | UniRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- autophagy Source: UniProtKB-KW
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Biological process | AutophagyUniRule annotationARBA annotation, Protein transportUniRule annotation, Transport, Ubl conjugation pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 65 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 65 | BasicSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR032916, ATG4B_met IPR038765, Papain-like_cys_pep_sf IPR005078, Peptidase_C54 |
PANTHERi | PTHR22624, PTHR22624, 1 hit PTHR22624:SF39, PTHR22624:SF39, 1 hit |
Pfami | View protein in Pfam PF03416, Peptidase_C54, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DZK0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGGVAPAGQ VRTATWARRA RPYRKMAART GTELASAAST TAPGSSKRRK
60 70 80 90 100
RHPWHTVSRR PGRTPKWRLP RISARAPYRL RRLRRHTYWP PRRPVAASRC
110 120 130 140 150
WPVGATPLGS VGGRTGKMDA ATLTYDTLRF AEFEDFPETS EPVWILGRKY
160 170 180 190 200
SIFTEKDEIL SDVASRLWFT YRKNFPAIGG TGPTSDTGWG CMLRCGQMIF
210 220 230 240 250
AQALVCRHLG RDWRWTQRKR QPDSYFSVLN AFIDRKDSYY SIHQIAQMGV
260 270 280 290 300
GEGKSIGQWY GPNTVAQVLK KLAVFDTWSS LAVHIAMDNT VVMEEIRRLC
310 320 330 340 350
RTSVPCAGAT AFPADSDRHC NGFPAGAEVT NRPSPWRPLV LLIPLRLGLT
360 370 380 390 400
DINEAYVETL KHCFMMPQSL GVIGGKPNSA HYFIGYVGEE LIYLDPHTTQ
410 420 430 440 450
PAVEPTDGCF IPDESFHCQH PPCRMSIAEL DPSIAVGFFC KTEDDFNDWC
460 470 480 490 500
QQVKKLSLLG GALPMFELVE QQPSHLACPD VLNLSLDSSD VERLERFFDS
510
EDEDFEILSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302963 mRNA Translation: BAG64112.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302963 mRNA Translation: BAG64112.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4DZK0 |
PeptideAtlasi | B4DZK0 |
PRIDEi | B4DZK0 |
Family and domain databases
InterProi | View protein in InterPro IPR032916, ATG4B_met IPR038765, Papain-like_cys_pep_sf IPR005078, Peptidase_C54 |
PANTHERi | PTHR22624, PTHR22624, 1 hit PTHR22624:SF39, PTHR22624:SF39, 1 hit |
Pfami | View protein in Pfam PF03416, Peptidase_C54, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DZK0_HUMAN | |
Accessioni | B4DZK0Primary (citable) accession number: B4DZK0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |