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Entry version 57 (31 Jul 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ53590, highly similar to Nuclear receptor coactivator 3

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ53590, highly similar to Nuclear receptor coactivator 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4DYT5

PRoteomics IDEntifications database

More...
PRIDEi
B4DYT5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1085 – 1142DUF1518InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni202 – 288DisorderedSequence analysisAdd BLAST87
Regioni296 – 315DisorderedSequence analysisAdd BLAST20
Regioni332 – 469DisorderedSequence analysisAdd BLAST138
Regioni543 – 594DisorderedSequence analysisAdd BLAST52
Regioni706 – 742DisorderedSequence analysisAdd BLAST37
Regioni1067 – 1128DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 315PolarSequence analysisAdd BLAST18
Compositional biasi332 – 367PolarSequence analysisAdd BLAST36
Compositional biasi385 – 399PolyampholyteSequence analysisAdd BLAST15
Compositional biasi423 – 469PolarSequence analysisAdd BLAST47
Compositional biasi556 – 575PolarSequence analysisAdd BLAST20
Compositional biasi1067 – 1082PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ5R Eukaryota
ENOG410ZDZC LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.1070, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010011 DUF1518
IPR032565 DUF4927
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR035965 PAS-like_dom_sf
IPR014935 SRC/p160_LXXLL

The PANTHER Classification System

More...
PANTHERi
PTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF08832 SRC-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01151 DUF1518, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55785 SSF55785, 1 hit
SSF69125 SSF69125, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DYT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMKTPHDIL EDINASPEMR QRYETMQCFA LSQPRAMMEE GEDLQSCMIC
60 70 80 90 100
VARRITTGER TFPSNPESFI TRHDLSGKVV NIDTNSLRSS MRPGFEDIIR
110 120 130 140 150
RCIQRFFSLN DGQSWSQKRH YQEETPVYRF SLADGTIVTA QTKSKLFRNP
160 170 180 190 200
VTNDRHGFVS THFLQREQNG YRPNPNPVGQ GIRPPMAGCN SSVGGMSMSP
210 220 230 240 250
NQGLQMPSSR AYGLADPSTT GQMSGARYGG SSNIASLTPG PGMQSPSSYQ
260 270 280 290 300
NNNYGLNMSS PPHGSPGLAP NQQNIMISPR NRGSPKIASH QFSPVAGVHS
310 320 330 340 350
PMASSGNTGN HSFSSSSLSA LQAISEGVGT SLLSTLSSPG PKLDNSPNMN
360 370 380 390 400
ITQPSKVSNQ DSKSPLGFYC DQNPVESSMC QSNSRDHLSD KESKESSVEG
410 420 430 440 450
AENQRGPLES KGHKKLLQLL TCSSDDRGHS SLTNSPLDSS CKESSVSVTS
460 470 480 490 500
PSGVSSSTSG GVSSTSNMHG SLLQEKHRIL HKLLQNGNSP AEVAKITAEA
510 520 530 540 550
TGKDTSSITS CGDGNVVKQE QLSPKKKENN ALLRYLLDRD DPSDALSKEL
560 570 580 590 600
QPQVEGVDNK MSQCTSSTIP SSSQEKDPKI KTETSEEGSG DLDNLDAILG
610 620 630 640 650
DLTSSDFYNN SISSNGSHLG TKQQVFQGTN SLGLKSSQSV QSIRPPYNRA
660 670 680 690 700
VSLDSPVSVG SSPPVKNISA FPMLPKQPML GGNPRMMDSQ ENYGSSMGGP
710 720 730 740 750
NRNVTVTQTP SSGDWGLPNS KAGRMEPMNS NSMGRPGGDY NTSLPRPALG
760 770 780 790 800
GSIPTLPLRS NSIPGARPVL QQQQQMLQMR PGEIPMGMGA NPYGQAAASN
810 820 830 840 850
QLGSWPDGML SMEQVSHGTQ NRPLLRNSLD DLVGPPSNLE GQSDERALLD
860 870 880 890 900
QLHTLLSNTD ATGLEEIDRA LGIPELVNQG QALEPKQDAF QGQEAAVMMD
910 920 930 940 950
QKAGLYGQTY PAQGPPMQGG FHLQGQSPSF NSMMNQMNQQ GNFPLQGMHP
960 970 980 990 1000
RANIMRPRTN TPKQLRMQLQ QRLQGQQFLN QSRQALELKM ENPTAGGAAV
1010 1020 1030 1040 1050
MRPMMQPQVS SQQGFLNAQM VAQRSRELLS HHFRQQRVAM MMQQQQQQQQ
1060 1070 1080 1090 1100
QQQQQQQQQQ QQQQQQQQQQ TQAFSPPPNV TASPSMDGLL AGPTMPQAPP
1110 1120 1130 1140 1150
QQFPYQPNYG MGQQPDPAFG RVSSPPNAMM SSRMGPSQNP MMQHPQAASI
1160 1170 1180 1190 1200
YQSSEMKGWP SGNLARNSSF SQQQFAHQGN PAVYSMVHMN GSSGHMGQMN
1210
MNPMPMSGMP MGPDQKYC
Length:1,218
Mass (Da):132,120
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AD99882A9D5BF97
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK302595 mRNA Translation: BAG63847.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302595 mRNA Translation: BAG63847.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4DYT5
PRIDEiB4DYT5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IQ5R Eukaryota
ENOG410ZDZC LUCA

Family and domain databases

Gene3Di1.10.287.1070, 1 hit
InterProiView protein in InterPro
IPR010011 DUF1518
IPR032565 DUF4927
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR035965 PAS-like_dom_sf
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF08832 SRC-1, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
SSF69125 SSF69125, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DYT5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DYT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 31, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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