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UniProtKB - B4DXU5 (B4DXU5_HUMAN)
Protein
Submitted name:
Oxysterols receptor LXR-alpha
Gene
NR1H3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Oxysterols receptor LXR-alphaSubmitted name: cDNA FLJ56172, highly similar to Oxysterols receptor LXR-alphaImported |
Gene namesi | Name:NR1H3 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7966, NR1H3 |
VEuPathDBi | HostDB:ENSG00000025434 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000025434, Expressed in right lobe of liver and 183 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 176 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 215 – 453 | NR LBDInterPro annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 71 – 94 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 186 – 208 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159068 |
OrthoDBi | 1137281at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
B4DXU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQTSWNPLG GTCKQPPGRT HSAVELWKPG AQDASSQAQG GSSCILREEA
60 70 80 90 100
RMPHSAGGTA GVGLEAAEPT ALLTRAEPPS EPTEIRPQKR KKGPAPKMLG
110 120 130 140 150
NELCSVCGDK ASGFHYNVLS CEGCKGFFRR SVIKGAHYIC HSGGHCPMDT
160 170 180 190 200
YMRRKCQECR LRKCRQAGMR EECVLSEEQI RLKKLKRQEE EQAHATSLPP
210 220 230 240 250
RASSPPQILP QLSPEQLGMI EKLVAAQQQC NRRSFSDRLR VTPWPMAPDP
260 270 280 290 300
HSREARQQRF AHFTELAIVS VQEIVDFAKQ LPGFLQLSRE DQIALLKTSA
310 320 330 340 350
IEVMLLETSR RYNPGSESIT FLKDFSYNRE DFAKAGLQVE FINPIFEFSR
360 370 380 390 400
AMNELQLNDA EFALLIAISI FSADRPNVQD QLQVERLQHT YVEALHAYVS
410 420 430 440 450
IHHPHDRLMF PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD
VHE
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13133 | NR1H3_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 LXRA | 447 | Annotation score: | ||
C9JBS2 | C9JBS2_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 212 | Annotation score: | ||
C9J4R0 | C9J4R0_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 193 | Annotation score: | ||
C9JJ16 | C9JJ16_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 202 | Annotation score: | ||
C9JCS0 | C9JCS0_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 205 | Annotation score: | ||
E9PLL4 | E9PLL4_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 466 | Annotation score: | ||
B5MBY7 | B5MBY7_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 342 | Annotation score: | ||
E9PID2 | E9PID2_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 296 | Annotation score: | ||
E9PPA1 | E9PPA1_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 167 | Annotation score: | ||
C9J2C8 | C9J2C8_HUMAN | Oxysterols receptor LXR-alpha | NR1H3 | 134 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018410 Genomic DNA No translation available. AK302132 mRNA Translation: BAG63507.1 |
RefSeqi | NP_001238863.1, NM_001251934.1 NP_001238864.1, NM_001251935.1 NP_005684.2, NM_005693.3 |
Genome annotation databases
Ensembli | ENST00000616973.4; ENSP00000477707.1; ENSG00000025434.19 |
GeneIDi | 10062 |
KEGGi | hsa:10062 |
UCSCi | uc009yll.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018410 Genomic DNA No translation available. AK302132 mRNA Translation: BAG63507.1 |
RefSeqi | NP_001238863.1, NM_001251934.1 NP_001238864.1, NM_001251935.1 NP_005684.2, NM_005693.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 13611, 578 antibodies from 39 providers |
DNASUi | 10062 |
Genome annotation databases
Ensembli | ENST00000616973.4; ENSP00000477707.1; ENSG00000025434.19 |
GeneIDi | 10062 |
KEGGi | hsa:10062 |
UCSCi | uc009yll.3, human |
Organism-specific databases
CTDi | 10062 |
HGNCi | HGNC:7966, NR1H3 |
OpenTargetsi | ENSG00000025434 |
VEuPathDBi | HostDB:ENSG00000025434 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159068 |
OrthoDBi | 1137281at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10062, 26 hits in 1108 CRISPR screens |
GenomeRNAii | 10062 |
Gene expression databases
Bgeei | ENSG00000025434, Expressed in right lobe of liver and 183 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DXU5_HUMAN | |
Accessioni | B4DXU5Primary (citable) accession number: B4DXU5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |