UniProtKB - B4DXG3 (B4DXG3_HUMAN)
Protein
Growth/differentiation factor 9
Gene
GDF9
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Growth/differentiation factor 9ARBA annotation |
Gene namesi | Name:GDF9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4224, GDF9 |
VEuPathDBi | HostDB:ENSG00000164404.8 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000164404, Expressed in oocyte and 117 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 228 – 366 | TGF_BETA_2InterPro annotationAdd BLAST | 139 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 215 – 242 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 219 – 237 | PolyampholyteSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159784 |
HOGENOMi | CLU_055377_1_0_1 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR015617, Growth_differentiation_fac-9 IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit PTHR11848:SF19, PTHR11848:SF19, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B4DXG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKLYKTYAT KEGIPKSNRS HLYNTVRLFT PCTRHKQAPG DQVTGILPSV
60 70 80 90 100
ELLFNLDRIT TVEHLLKSVL LYNINNSVSF SSAVKCVCNL MIKEPKSSSR
110 120 130 140 150
TLGRAPYSFT FNSQFEFGKK HKWIQIDVTS LLQPLVASNK RSIHMSINFT
160 170 180 190 200
CMKDQLEHPS AQNGLFNMTL VSPSLILYLN DTSAQAYHSW YSLHYKRRPS
210 220 230 240 250
QGPDQERSLS AYPVGEEAAE DGRSSHHRHR RGQETVSSEL KKPLGPASFN
260 270 280 290 300
LSEYFRQFLL PQNECELHDF RLSFSQLKWD NWIVAPHRYN PRYCKGDCPR
310 320 330 340 350
AVGHRYGSPV HTMVQNIIYE KLDSSVPRPS CVPAKYSPLS VLTIEPDGSI
360
AYKEYEDMIA TKCTCR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO60383 | GDF9_HUMAN | Growth/differentiation factor 9 | GDF9 | 454 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004500 Genomic DNA No translation available. AK301962 mRNA Translation: BAG63375.1 AK315973 mRNA Translation: BAH14344.1 |
RefSeqi | NP_001275753.1, NM_001288824.2 NP_001275754.1, NM_001288825.2 NP_001275755.1, NM_001288826.2 NP_001275756.1, NM_001288827.2 NP_001275757.1, NM_001288828.2 XP_005272014.1, XM_005271957.4 XP_006714648.1, XM_006714585.3 XP_011541611.1, XM_011543309.1 XP_011541612.1, XM_011543310.1 |
Genome annotation databases
Ensembli | ENST00000296875; ENSP00000296875; ENSG00000164404 ENST00000621295; ENSP00000484339; ENSG00000164404 ENST00000624492; ENSP00000485037; ENSG00000164404 ENST00000624495; ENSP00000485231; ENSG00000164404 |
GeneIDi | 2661 |
UCSCi | uc011cxj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004500 Genomic DNA No translation available. AK301962 mRNA Translation: BAG63375.1 AK315973 mRNA Translation: BAH14344.1 |
RefSeqi | NP_001275753.1, NM_001288824.2 NP_001275754.1, NM_001288825.2 NP_001275755.1, NM_001288826.2 NP_001275756.1, NM_001288827.2 NP_001275757.1, NM_001288828.2 XP_005272014.1, XM_005271957.4 XP_006714648.1, XM_006714585.3 XP_011541611.1, XM_011543309.1 XP_011541612.1, XM_011543310.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 26178, 555 antibodies |
DNASUi | 2661 |
Genome annotation databases
Ensembli | ENST00000296875; ENSP00000296875; ENSG00000164404 ENST00000621295; ENSP00000484339; ENSG00000164404 ENST00000624492; ENSP00000485037; ENSG00000164404 ENST00000624495; ENSP00000485231; ENSG00000164404 |
GeneIDi | 2661 |
UCSCi | uc011cxj.3, human |
Organism-specific databases
CTDi | 2661 |
HGNCi | HGNC:4224, GDF9 |
OpenTargetsi | ENSG00000164404 |
VEuPathDBi | HostDB:ENSG00000164404.8 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159784 |
HOGENOMi | CLU_055377_1_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 2661, 3 hits in 985 CRISPR screens |
ChiTaRSi | GDF9, human |
GenomeRNAii | 2661 |
Gene expression databases
Bgeei | ENSG00000164404, Expressed in oocyte and 117 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR015617, Growth_differentiation_fac-9 IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit PTHR11848:SF19, PTHR11848:SF19, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DXG3_HUMAN | |
Accessioni | B4DXG3Primary (citable) accession number: B4DXG3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |