Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 736

Gene

ZNF736

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 736
Gene namesi
Name:ZNF736
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000234444.9
HGNCiHGNC:32467 ZNF736
neXtProtiNX_B4DX44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234444

Polymorphism and mutation databases

BioMutaiZNF736

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953431 – 427Zinc finger protein 736Add BLAST427

Proteomic databases

PaxDbiB4DX44
PRIDEiB4DX44
ProteomicsDBi5408

PTM databases

iPTMnetiB4DX44
PhosphoSitePlusiB4DX44

Expressioni

Gene expression databases

BgeeiENSG00000234444 Expressed in 187 organ(s), highest expression level in kidney
ExpressionAtlasiB4DX44 baseline and differential
GenevisibleiB4DX44 HS

Organism-specific databases

HPAiHPA051027
HPA061215

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347210

Structurei

3D structure databases

ProteinModelPortaliB4DX44
SMRiB4DX44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiB4DX44
KOiK09228
OMAiERCYKCE
OrthoDBiEOG091G02KC
PhylomeDBiB4DX44
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

B4DX44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL VSLGLAIFKP
60 70 80 90 100
DLMTCLEQRK EPWKVKRQEA VAKHPAGSFH FTAEILPDHD IKDSFQKVIL
110 120 130 140 150
RKYGSCDLNN LHLKKDYQSV GNCKGQKSSY NGLHQCLSAT HSKTCQCNKC
160 170 180 190 200
GRGFQLCSIF TEHKDIFSRE KCHKCEECGK DCRLFSDFTR HKKIHTVERC
210 220 230 240 250
YKCEECGKAF KKFSNLTEHK RVHTGEKPYK CEGCGKTFTC SSTLVKHKRN
260 270 280 290 300
HTGDRPYKCE ECGKAFKCFS DLTNHKRIHT GEKPYKCEEC NKAYRWFSDL
310 320 330 340 350
AKHKIIHTGD KPYTCNECGK AFKWFSALSK HKRIHTGEKP YICEECGKAF
360 370 380 390 400
TRSSTLFNHK RIHMEERPYK CEECSKTFKC FSDLTNHKRI HTGEKPYKCE
410 420
ECGKASSWFS HLIRHKRIHT REKLHKC
Length:427
Mass (Da):49,868
Last modified:June 28, 2011 - v2
Checksum:i6C26A8CCF635DD88
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMN6A0A1D5RMN6_HUMAN
Zinc finger protein 736
ZNF736
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268C → R in BAG63256 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301806 mRNA Translation: BAG63256.1
AC073270 Genomic DNA No translation available.
CCDSiCCDS55114.1
RefSeqiNP_001164376.1, NM_001170905.2
UniGeneiHs.386162
Hs.734771

Genome annotation databases

EnsembliENST00000355095; ENSP00000347210; ENSG00000234444
ENST00000423484; ENSP00000400852; ENSG00000234444
GeneIDi728927
KEGGihsa:728927
UCSCiuc003tsz.5 human

Similar proteinsi

Entry informationi

Entry nameiZN736_HUMAN
AccessioniPrimary (citable) accession number: B4DX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again