UniProtKB - B4DX41 (B4DX41_HUMAN)
Protein
Submitted name:
Cyclin-dependent kinase-like 3
Gene
CDKL3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase-like 3ImportedSubmitted name: cDNA FLJ50724, highly similar to Cyclin-dependent kinase-like 3Imported |
Gene namesi | Name:CDKL3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15483, CDKL3 |
VEuPathDBi | HostDB:ENSG00000006837.11 |
Expressioni
Gene expression databases
Bgeei | ENSG00000006837, Expressed in testis and 121 other tissues |
ExpressionAtlasi | B4DX41, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 178 – 201 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 270 – 297 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 357 – 401 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 178 – 193 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 277 – 295 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 368 – 393 | PolarSequence analysisAdd BLAST | 26 |
Phylogenomic databases
GeneTreei | ENSGT00940000161317 |
HOGENOMi | CLU_720682_0_0_1 |
OrthoDBi | 398098at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
B4DX41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIIEMATGNP YLPSSSDLDL LHKIVLKVGN LSPHLQNIFS KSPIFAGVVL
60 70 80 90 100
PQVQHPKNAR KKYPKLNGLL ADIVHACLQI DPADRISSSD LLHHEYFTRD
110 120 130 140 150
GFIEKFMPEL KAKLLQEAKV NSLIKPKESS KENELRKDER KTVYTNTLLS
160 170 180 190 200
SSVLGKEIEK EKKPKEIKVR VIKVKGGRGD ISEPKKKEYE GGLGQQDANE
210 220 230 240 250
NVHPMSPDTK LVTIEPPNPI NPSTNCNGLK ENPHCGGSVT MPPINLTNSN
260 270 280 290 300
LMAANLSSNL FHPSVRLTER AKKRRTSSQS IGQVMPNSRQ EDPGPIQSQM
310 320 330 340 350
EKGIFNERTG HSDQMANENK RKLNFSRSDR KEFHFPELPV TIQSKDTKGM
360 370 380 390 400
EVKQIKMLKR ESKKTESSKI PTLLNVDQNQ EKQENTGNAQ TERKKNLPDV
E
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IVW4 | CDKL3_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 NKIAMRE | 592 | Annotation score: | ||
E7ET86 | E7ET86_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 590 | Annotation score: | ||
E5RGK4 | E5RGK4_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 106 | Annotation score: | ||
H0YAP8 | H0YAP8_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 73 | Annotation score: | ||
E5RFT9 | E5RFT9_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 44 | Annotation score: | ||
E5RI54 | E5RI54_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 82 | Annotation score: | ||
H0YB17 | H0YB17_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 18 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104109 Genomic DNA No translation available. AC109454 Genomic DNA No translation available. AK301802 mRNA Translation: BAG63253.1 |
RefSeqi | NP_001287782.1, NM_001300853.1 |
Genome annotation databases
Ensembli | ENST00000523054; ENSP00000428500; ENSG00000006837 |
GeneIDi | 51265 |
UCSCi | uc063hax.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104109 Genomic DNA No translation available. AC109454 Genomic DNA No translation available. AK301802 mRNA Translation: BAG63253.1 |
RefSeqi | NP_001287782.1, NM_001300853.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4DX41 |
PRIDEi | B4DX41 |
ProteomicsDBi | 5406 |
Protocols and materials databases
Antibodypediai | 2061, 190 antibodies |
Genome annotation databases
Ensembli | ENST00000523054; ENSP00000428500; ENSG00000006837 |
GeneIDi | 51265 |
UCSCi | uc063hax.1, human |
Organism-specific databases
CTDi | 51265 |
HGNCi | HGNC:15483, CDKL3 |
OpenTargetsi | ENSG00000006837 |
VEuPathDBi | HostDB:ENSG00000006837.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161317 |
HOGENOMi | CLU_720682_0_0_1 |
OrthoDBi | 398098at2759 |
Miscellaneous databases
BioGRID-ORCSi | 51265, 5 hits in 900 CRISPR screens |
ChiTaRSi | CDKL3, human |
GenomeRNAii | 51265 |
Gene expression databases
Bgeei | ENSG00000006837, Expressed in testis and 121 other tissues |
ExpressionAtlasi | B4DX41, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DX41_HUMAN | |
Accessioni | B4DX41Primary (citable) accession number: B4DX41 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |