UniProtKB - B4DWA2 (B4DWA2_HUMAN)
Protein
Submitted name:
cDNA FLJ52786, highly similar to Caspase-7
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Biological process | ApoptosisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ52786, highly similar to Caspase-7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Keywords - Cellular componenti
CytoplasmARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 198 | CASPASE_P20InterPro annotationAdd BLAST | 125 | |
Domaini | 217 – 311 | CASPASE_P10InterPro annotationAdd BLAST | 95 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 984395at2759 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DWA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRAVLKSRG LRIQQMKIQW MLSQTGPRLY RPSSAPDSGT LYFTSKKKKN
60 70 80 90 100
VTMRSIKTTR DRVPTYQYNM NFEKLGKCII INNKNFDKVT GMGVRNGTVK
110 120 130 140 150
DAEALFKCFR SLGFDVIVYN DCSCAKMQDL LKKASEEDHT NAACFACILL
160 170 180 190 200
SHGEENVIYG KDGVTPIKDL TAHFRGDRCK TLLEKPKLFF IQACRGTELD
210 220 230 240 250
DGVQADSGPI NDTDANPRYK IPVEADFLFA YSTVPGYYSW RSPGRGSWFV
260 270 280 290 300
QALCSILEEH GKDLEIMQIL TRVNDRVARH FESQSDDPHF HEKKQIPCVV
310
SMLTKELYFS Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301437 mRNA Translation: BAG62964.1 |
RefSeqi | NP_001253986.1, NM_001267057.1 |
Genome annotation databases
GeneIDi | 840 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301437 mRNA Translation: BAG62964.1 |
RefSeqi | NP_001253986.1, NM_001267057.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B4DWA2 |
Genome annotation databases
GeneIDi | 840 |
Organism-specific databases
CTDi | 840 |
Phylogenomic databases
OrthoDBi | 984395at2759 |
Miscellaneous databases
BioGRID-ORCSi | 840, 3 hits in 880 CRISPR screens |
GenomeRNAii | 840 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DWA2_HUMAN | |
Accessioni | B4DWA2Primary (citable) accession number: B4DWA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |