UniProtKB - B4DWA1 (B4DWA1_HUMAN)
Protein
Brain-specific angiogenesis inhibitor 1-associated protein 2
Gene
BAIAP2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytoskeletal anchor activity Source: InterPro
GO - Biological processi
- plasma membrane organization Source: InterPro
- regulation of actin cytoskeleton organization Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Brain-specific angiogenesis inhibitor 1-associated protein 2ARBA annotation |
Gene namesi | Name:BAIAP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:947, BAIAP2 |
VEuPathDBi | HostDB:ENSG00000175866.15 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- filopodium ARBA annotation
- ruffle ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- filopodium Source: UniProtKB-SubCell
- ruffle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, MembraneARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | B4DWA1 |
PRIDEi | B4DWA1 |
ProteomicsDBi | 5325 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175866, Expressed in Brodmann (1909) area 10 and 207 other tissues |
ExpressionAtlasi | B4DWA1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 113 | IMDInterPro annotationAdd BLAST | 113 | |
Domaini | 237 – 300 | SH3InterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 232 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 308 – 340 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 185 – 230 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 308 – 322 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153560 |
Family and domain databases
CDDi | cd11915, SH3_Irsp53, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR013606, I-BAR_dom IPR030128, IRSp53 IPR027681, IRSp53/IRTKS/Pinkbar IPR035594, Irsp53_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR14206, PTHR14206, 1 hit PTHR14206:SF3, PTHR14206:SF3, 1 hit |
Pfami | View protein in Pfam PF08397, IMD, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51338, IMD, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All
B4DWA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLPEGQRQR ALGFGTVTST YSPVGQYIDA ISNKQGELEN YVSDGYKTAL
60 70 80 90 100
TEERRRFCFL VEKQCAVAKN SAAYHSKGKE LLAQKLPLWQ QACADPSKIP
110 120 130 140 150
ERAVQLMQQV ASNGATLPSA LSASKSNLVI SDPIPGAKPL PVPPELAPFV
160 170 180 190 200
GRMSAQESTP IMNGVTGPDG EDYSPWADRK AAQPKSLSPP QSQSKLSDSY
210 220 230 240 250
SNTLPVRKSV TPKNSYATTE NKTLPRSSSM AAGLERNGRM RVKAIFSHAA
260 270 280 290 300
GDNSTLLSFK EGDLITLLVP EARDGWHYGE SEKTKMRGWF PFSYTRVLDS
310 320 330 340 350
DGSDRLHMSL QQGKSSSTGN LLDKDDLAIP PPDYGAASRA FPAQTASGFK
360 370
QRPYSVAVPA FSQGLDDYGA RSMSR
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UQB8 | BAIP2_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 552 | Annotation score: | ||
I3L4C2 | I3L4C2_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 553 | Annotation score: | ||
I3L526 | I3L526_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 114 | Annotation score: | ||
I3L4A3 | I3L4A3_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 97 | Annotation score: | ||
I3L0M4 | I3L0M4_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 140 | Annotation score: | ||
I3L113 | I3L113_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 79 | Annotation score: | ||
I3L125 | I3L125_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 135 | Annotation score: | ||
I3L1C8 | I3L1C8_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 180 | Annotation score: | ||
I3L2M4 | I3L2M4_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 234 | Annotation score: | ||
I3L327 | I3L327_HUMAN | Brain-specific angiogenesis inhibit... | BAIAP2 | 175 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC115099 Genomic DNA No translation available. AC127496 Genomic DNA No translation available. KC877672 Genomic DNA No translation available. AK301436 mRNA Translation: BAG62963.1 |
Genome annotation databases
Ensembli | ENST00000416299; ENSP00000391837; ENSG00000175866 |
UCSCi | uc060lgt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC115099 Genomic DNA No translation available. AC127496 Genomic DNA No translation available. KC877672 Genomic DNA No translation available. AK301436 mRNA Translation: BAG62963.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4DWA1 |
PRIDEi | B4DWA1 |
ProteomicsDBi | 5325 |
Protocols and materials databases
Antibodypediai | 19790, 539 antibodies |
Genome annotation databases
Ensembli | ENST00000416299; ENSP00000391837; ENSG00000175866 |
UCSCi | uc060lgt.1, human |
Organism-specific databases
HGNCi | HGNC:947, BAIAP2 |
OpenTargetsi | ENSG00000175866 |
VEuPathDBi | HostDB:ENSG00000175866.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153560 |
Miscellaneous databases
ChiTaRSi | BAIAP2, human |
Gene expression databases
Bgeei | ENSG00000175866, Expressed in Brodmann (1909) area 10 and 207 other tissues |
ExpressionAtlasi | B4DWA1, baseline and differential |
Family and domain databases
CDDi | cd11915, SH3_Irsp53, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR013606, I-BAR_dom IPR030128, IRSp53 IPR027681, IRSp53/IRTKS/Pinkbar IPR035594, Irsp53_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR14206, PTHR14206, 1 hit PTHR14206:SF3, PTHR14206:SF3, 1 hit |
Pfami | View protein in Pfam PF08397, IMD, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51338, IMD, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DWA1_HUMAN | |
Accessioni | B4DWA1Primary (citable) accession number: B4DWA1 Secondary accession number(s): E9PCF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |