UniProtKB - B4DW13 (B4DW13_HUMAN)
Protein
Cysteine-S-conjugate beta-lyase 2
Gene
hCG_23341
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:4.4.1.13ARBA annotation
Cofactori
pyridoxal 5'-phosphateARBA annotation
GO - Molecular functioni
- cysteine-S-conjugate beta-lyase activity Source: UniProtKB-EC
- kynurenine-glyoxylate transaminase activity Source: UniProtKB-EC
- kynurenine-oxoglutarate transaminase activity Source: UniProtKB-EC
- protein homodimerization activity Source: Ensembl
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- 2-oxoglutarate metabolic process Source: Ensembl
- biosynthetic process Source: InterPro
Keywordsi
Molecular function | AminotransferaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-S-conjugate beta-lyase 2ARBA annotation (EC:2.6.1.63ARBA annotation, EC:2.6.1.7ARBA annotation, EC:4.4.1.13ARBA annotation)Alternative name(s): Kynurenine aminotransferase 3ARBA annotation Kynurenine aminotransferase IIIARBA annotation Kynurenine--glyoxylate transaminaseARBA annotation Kynurenine--oxoglutarate transaminase 3ARBA annotation Kynurenine--oxoglutarate transaminase IIIARBA annotation |
Gene namesi | ORF Names:hCG_23341Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000137944.16 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137944, Expressed in parotid gland and 240 other tissues |
ExpressionAtlasi | B4DW13, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationGO - Molecular functioni
- protein homodimerization activity Source: Ensembl
Chemistry databases
BindingDBi | B4DW13 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 442 | Aminotran_1_2InterPro annotationAdd BLAST | 379 |
Phylogenomic databases
OMAi | SVAMTGW |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR034612, KAT_III IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR43807:SF6, PTHR43807:SF6, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DW13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS
60 70 80 90 100
NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG
110 120 130 140 150
FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD
160 170 180 190 200
EVILIVPFYD CYEPMVRMAG ATPVFIPLRS KPVYGKRWSS SDWTLDPQEL
210 220 230 240 250
ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD TLCISDEVYE
260 270 280 290 300
WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK
310 320 330 340 350
HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMVRLLESV GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW
410 420 430 440 450
MTKHKKLSAI PVSAFCNSET KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS
VQKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301326 mRNA Translation: BAG62875.1 AK315917 mRNA Translation: BAH14288.1 CH471097 Genomic DNA Translation: EAW73158.1 |
RefSeqi | NP_001008661.1, NM_001008661.2 |
Genome annotation databases
GeneIDi | 56267 |
KEGGi | hsa:56267 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301326 mRNA Translation: BAG62875.1 AK315917 mRNA Translation: BAH14288.1 CH471097 Genomic DNA Translation: EAW73158.1 |
RefSeqi | NP_001008661.1, NM_001008661.2 |
3D structure databases
SMRi | B4DW13 |
ModBasei | Search... |
Chemistry databases
BindingDBi | B4DW13 |
Proteomic databases
PRIDEi | B4DW13 |
Protocols and materials databases
Antibodypediai | 19822, 84 antibodies |
Genome annotation databases
GeneIDi | 56267 |
KEGGi | hsa:56267 |
Organism-specific databases
CTDi | 56267 |
PharmGKBi | PA162381274 |
VEuPathDBi | HostDB:ENSG00000137944.16 |
Phylogenomic databases
OMAi | SVAMTGW |
Miscellaneous databases
BioGRID-ORCSi | 56267, 3 hits in 877 CRISPR screens |
GenomeRNAii | 56267 |
Gene expression databases
Bgeei | ENSG00000137944, Expressed in parotid gland and 240 other tissues |
ExpressionAtlasi | B4DW13, baseline and differential |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR034612, KAT_III IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR43807:SF6, PTHR43807:SF6, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DW13_HUMAN | |
Accessioni | B4DW13Primary (citable) accession number: B4DW13 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |