UniProtKB - B4DVM1 (B4DVM1_HUMAN)
Protein
Interleukin-6
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-6 receptor binding Source: InterPro
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- T-helper 17 cell lineage commitment Source: InterPro
Keywordsi
Molecular function | CytokineARBA annotation |
Biological process | Acute phaseARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6ARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5002803597 | 28 – 198 | Interleukin-6Sequence analysisAdd BLAST | 171 |
Proteomic databases
PeptideAtlasi | B4DVM1 |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-6 receptor binding Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-6 superfamily.ARBA annotation
Keywords - Domaini
SignalSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DVM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESGEGQA RAVQMSTKVL
160 170 180 190
IQFLQKKVGV SSFPQLGVGE DRLKDSVLDN SGMQCHFQKR RLHVNKRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301141 mRNA Translation: BAG62733.1 |
RefSeqi | NP_000591.1, NM_000600.4 |
Genome annotation databases
GeneIDi | 3569 |
KEGGi | hsa:3569 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301141 mRNA Translation: BAG62733.1 |
RefSeqi | NP_000591.1, NM_000600.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B4DVM1 |
Protocols and materials databases
DNASUi | 3569 |
Genome annotation databases
GeneIDi | 3569 |
KEGGi | hsa:3569 |
Organism-specific databases
CTDi | 3569 |
PharmGKBi | PA198 |
Miscellaneous databases
BioGRID-ORCSi | 3569, 4 hits in 874 CRISPR screens |
GenomeRNAii | 3569 |
Gene expression databases
Genevisiblei | B4DVM1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DVM1_HUMAN | |
Accessioni | B4DVM1Primary (citable) accession number: B4DVM1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |