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Entry version 53 (08 May 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ61398, highly similar to Homo sapiens laminin, beta 4 (LAMB4), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ61398, highly similar to Homo sapiens laminin, beta 4 (LAMB4), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500280330520 – 1101Sequence analysisAdd BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi297 ↔ 306PROSITE-ProRule annotation
Disulfide bondi362 ↔ 371PROSITE-ProRule annotation
Disulfide bondi425 ↔ 434PROSITE-ProRule annotation
Disulfide bondi477 ↔ 486PROSITE-ProRule annotation
Disulfide bondi489 ↔ 503PROSITE-ProRule annotation
Disulfide bondi506 ↔ 518PROSITE-ProRule annotation
Disulfide bondi508 ↔ 525PROSITE-ProRule annotation
Disulfide bondi527 ↔ 536PROSITE-ProRule annotation
Disulfide bondi769 ↔ 781PROSITE-ProRule annotation
Disulfide bondi771 ↔ 788PROSITE-ProRule annotation
Disulfide bondi790 ↔ 799PROSITE-ProRule annotation
Disulfide bondi817 ↔ 829PROSITE-ProRule annotation
Disulfide bondi819 ↔ 836PROSITE-ProRule annotation
Disulfide bondi838 ↔ 847PROSITE-ProRule annotation
Disulfide bondi882 ↔ 891PROSITE-ProRule annotation
Disulfide bondi894 ↔ 908PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1003PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1061PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4DTV7

PRoteomics IDEntifications database

More...
PRIDEi
B4DTV7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 264Laminin N-terminalInterPro annotationAdd BLAST241
Domaini265 – 331Laminin EGF-likeInterPro annotationAdd BLAST67
Domaini332 – 394Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini395 – 454Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini455 – 505Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini506 – 552Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini545 – 763Laminin IV type BInterPro annotationAdd BLAST219
Domaini769 – 816Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini817 – 862Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini863 – 910Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini911 – 969Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini970 – 1021Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1022 – 1079Laminin EGF-likeInterPro annotationAdd BLAST58

Keywords - Domaini

Laminin EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007552

KEGG Orthology (KO)

More...
KOi
K06245

Database of Orthologous Groups

More...
OrthoDBi
65841at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00180 EGF_Lam, 11 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 11 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DTV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG
60 70 80 90 100
LSRAQKYCIL SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR
110 120 130 140 150
EKKWWQSENG LDHVSIRLDL EALFRFSHLI LTFKTFRPAA MLVERSTDYG
160 170 180 190 200
HNWKVFKYFA KDCATSFPNI TSGQAQGVGD IVCDSKYSDI EPSTGGEVVL
210 220 230 240 250
KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLYTLGDAL LGRRQNDSLD
260 270 280 290 300
KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VYGQCVCQHN
310 320 330 340 350
TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA
360 370 380 390 400
SGGLSGGVCE DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD
410 420 430 440 450
GTISGGICVS HSDPALGSVA GQCLCKENVE GAKCDQCKPN HYGLSATDPL
460 470 480 490 500
GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY VTGAHCEECT VGYWGLGNHL
510 520 530 540 550
HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA PGYFFAPLNF
560 570 580 590 600
YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR
610 620 630 640 650
VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI
660 670 680 690 700
PKTLQSKPQS FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA
710 720 730 740 750
HSHVLVDSLG LIPQINSLEN FCSKQDLDEY QLHNCVEIAS AMGPQVLPGA
760 770 780 790 800
CERLIISMSA KLHDGAVACK CHPQGSVGSS CGRLGGQCQC KPLVVGRCCD
810 820 830 840 850
RCSTGSYDLG HHGCHPCHCH PQGSKDTVCD QVTGQCPCHG EVSGRRCDRC
860 870 880 890 900
LAGYFGFPSC HPCPCNRFAE LCDPETGSCF NCGGFTTGRN CERCIDGYYG
910 920 930 940 950
NPSSGQPCRP CLCPDDPSSN QYFAHSCYQN LWSSDVICNC LQGYTGTQCG
960 970 980 990 1000
ECSTGFYGNP RISGAPCQPC ACNNNIDVTD PESCSRVTGE CLRCLHNTQG
1010 1020 1030 1040 1050
ANCQLCKPGH YGSALNQTCR RCSCHASGVS PMECPPGGGA CLCDPVTGAC
1060 1070 1080 1090 1100
PCLPNVTGLA CDRCADGYWN LVPGRGCQSC DCDPRTSQSS HCDQARYFKA

Y
Length:1,101
Mass (Da):119,664
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF637A4E215C2AB13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK300385 mRNA Translation: BAG62119.1

NCBI Reference Sequences

More...
RefSeqi
NP_001304975.1, NM_001318046.1
NP_001304976.1, NM_001318047.1
NP_001304977.1, NM_001318048.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22798

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300385 mRNA Translation: BAG62119.1
RefSeqiNP_001304975.1, NM_001318046.1
NP_001304976.1, NM_001318047.1
NP_001304977.1, NM_001318048.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4DTV7
PRIDEiB4DTV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22798
KEGGihsa:22798

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22798

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
HOGENOMiHOG000007552
KOiK06245
OrthoDBi65841at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22798

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00180 EGF_Lam, 11 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 11 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DTV7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DTV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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