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Entry version 58 (11 Dec 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ50208, highly similar to Pappalysin-1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ50208, highly similar to Pappalysin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi453 ↔ 496PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4DTA8

PRoteomics IDEntifications database

More...
PRIDEi
B4DTA8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini251 – 320SushiInterPro annotationAdd BLAST70
Domaini321 – 382SushiInterPro annotationAdd BLAST62
Domaini383 – 450SushiInterPro annotationAdd BLAST68
Domaini451 – 511SushiInterPro annotationAdd BLAST61
Domaini514 – 594SushiInterPro annotationAdd BLAST81

Keywords - Domaini

SushiPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KDUG Eukaryota
ENOG410YRGU LUCA

KEGG Orthology (KO)

More...
KOi
K07762

Database of Orthologous Groups

More...
OrthoDBi
105200at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR030433 PAPPA
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

The PANTHER Classification System

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PANTHERi
PTHR46130:SF2 PTHR46130:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 4 hits
SM00004 NL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02232 myxo_disulf_rpt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DTA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKINGDGCS LFCRQEVSFN CIDEPSRCYF HDGDGVCEEF EQKTSIKDCG
60 70 80 90 100
VYTPQGFLDQ WASNASVSHQ DQQCPGWVII GQPAASQVCR TKVIDLSEGI
110 120 130 140 150
SQHAWYPCTI SYPYSQLAQT TFWLRAYFSQ PMVAAAVIVH LVTDGTYYGD
160 170 180 190 200
QKQETISVQL LDTKDQSHDL GLHVLSCRNN PLIIPVVHDL SQPFYHSQAV
210 220 230 240 250
RVSFSSPLVA ISGVALRSFD NFDPVTLSSC QRGETYSPAE QSCVHFACEK
260 270 280 290 300
TDCPELAVEN ASLNCSSSDR YHGAQCTVSC RTGYVLQIRR DDELIKSQTG
310 320 330 340 350
PSVTVTCTEG KWNKQVACEP VDCSIPDHHQ VYAASFSCPE GTTFGSQCSF
360 370 380 390 400
QCRHPAQLKG NNSLLTCMED GLWSFPEALC ELMCLAPPPV PNADLQTARC
410 420 430 440 450
RENKHKVGSF CKYKCKPGYH VPGSSRKSKK RAFKTQCTQD GSWQEGACAP
460 470 480 490 500
VTCDPPPPKF HGLYQCTNGF QFNSECRIKC EDSDASQGLG SNVIHCRKDG
510 520 530 540 550
TWNGSFHVCQ EMQGQCSVPN ELNSNLKLQC PDGYAIGSEC ATSCLDHNSE
560 570 580 590 600
SIILPMNVTV RDIPHWLNPT RVERVVCTAG LKWYPHPALI HCVKGCEPFM
610 620 630 640 650
GDNYCDAINN RAFCNYDGGD CCTSTVKTKK VTPFPMSCDL QGDCACRDPQ
660
AQEHSRKDLR GYSHG
Length:665
Mass (Da):73,521
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77276DD4FCE6FA11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK300129 mRNA Translation: BAG61920.1

NCBI Reference Sequences

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RefSeqi
NP_002572.2, NM_002581.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5069

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300129 mRNA Translation: BAG61920.1
RefSeqiNP_002572.2, NM_002581.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4DTA8
PRIDEiB4DTA8

Genome annotation databases

GeneIDi5069
KEGGihsa:5069

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5069

Phylogenomic databases

eggNOGiENOG410KDUG Eukaryota
ENOG410YRGU LUCA
KOiK07762
OrthoDBi105200at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5069

Family and domain databases

CDDicd00033 CCP, 4 hits
InterProiView protein in InterPro
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR030433 PAPPA
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR46130:SF2 PTHR46130:SF2, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 3 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00004 NL, 1 hit
SUPFAMiSSF57535 SSF57535, 4 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DTA8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DTA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 11, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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