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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

PTPN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108SubstrateUniRule annotation1
Active sitei142Phosphocysteine intermediateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000196396.9
HGNCiHGNC:9642 PTPN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei336 – 357HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196396

PTM / Processingi

Proteomic databases

EPDiB4DSN5
MaxQBiB4DSN5
PeptideAtlasiB4DSN5
PRIDEiB4DSN5

Expressioni

Gene expression databases

BgeeiENSG00000196396
ExpressionAtlasiB4DSN5 baseline and differential

Structurei

3D structure databases

SMRiB4DSN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 204Tyrosine-protein phosphataseInterPro annotationAdd BLAST204
Domaini116 – 195TYR_PHOSPHATASE_2InterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 148Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOVERGENiHBG008321

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012265 Ptpn1/Ptpn2
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

B4DSN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAQRSYIL TQGPLPNTCG HFWEMVWEQK SRGVVMLNRV MEKGSLKCAQ
60 70 80 90 100
YWPQKEEKEM IFEDTNLKLT LISEDIKSYY TVRQLELENL TTQETREILH
110 120 130 140 150
FHYTTWPDFG VPESPASFLN FLFKVRESGS LSPEHGPVVV HCSAGIGRSG
160 170 180 190 200
TFCLADTCLL LMDKRKDPSS VDIKKVLLEM RKFRMGLIQT ADQLRFSYLA
210 220 230 240 250
VIEGAKFIMG DSSVQDQWKE LSHEDLEPPP EHIPPPPRPP KRILEPHNGK
260 270 280 290 300
CREFFPNHQW VKEETQEDKD CPIKEEKGSP LNAAPYGIES MSQDTEVRSR
310 320 330 340 350
VVGGSLRGAQ AASPAKGEPS LPEKDEDHAL SYWKPFLVNM CVATVLTAGA
360
YLCYRFLFNS NT
Length:362
Mass (Da):41,260
Last modified:September 23, 2008 - v1
Checksum:iC4611A4F5A4B5982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034429 Genomic DNA No translation available.
AL133230 Genomic DNA No translation available.
KF456940 Genomic DNA No translation available.
AK299830 mRNA Translation: BAG61697.1
RefSeqiNP_001265547.1, NM_001278618.1
UniGeneiHs.417549

Genome annotation databases

EnsembliENST00000541713; ENSP00000437732; ENSG00000196396
GeneIDi5770
UCSCiuc010zys.4 human

Similar proteinsi

Entry informationi

Entry nameiB4DSN5_HUMAN
AccessioniPrimary (citable) accession number: B4DSN5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 18, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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