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Entry version 67 (02 Jun 2021)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ56483, highly similar to Eukaryotic translation initiation factor 4 gamma 1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImportedARBA annotation
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ56483, highly similar to Eukaryotic translation initiation factor 4 gamma 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4DSI9

PRoteomics IDEntifications database

More...
PRIDEi
B4DSI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B4DSI9, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1154 – 1276MIInterPro annotationAdd BLAST123
Domaini1346 – 1512W2InterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 135DisorderedSequence analysisAdd BLAST49
Regioni147 – 513DisorderedSequence analysisAdd BLAST367
Regioni580 – 626DisorderedSequence analysisAdd BLAST47
Regioni643 – 671DisorderedSequence analysisAdd BLAST29
Regioni937 – 1140DisorderedSequence analysisAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 103Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi111 – 131Polar residuesSequence analysisAdd BLAST21
Compositional biasi168 – 186Pro residuesSequence analysisAdd BLAST19
Compositional biasi198 – 216Polar residuesSequence analysisAdd BLAST19
Compositional biasi248 – 263Polar residuesSequence analysisAdd BLAST16
Compositional biasi290 – 307Pro residuesSequence analysisAdd BLAST18
Compositional biasi347 – 364Polar residuesSequence analysisAdd BLAST18
Compositional biasi366 – 384Acidic residuesSequence analysisAdd BLAST19
Compositional biasi403 – 417Polar residuesSequence analysisAdd BLAST15
Compositional biasi477 – 499Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi972 – 1000Polar residuesSequence analysisAdd BLAST29
Compositional biasi1025 – 1054Polar residuesSequence analysisAdd BLAST30
Compositional biasi1055 – 1136Basic and acidic residuesSequence analysisAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.ARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRGGPNM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF10, PTHR23253:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DSI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMIPSQISYP ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP GFYPGASPTE
60 70 80 90 100
FGTYAGAYYP AQGVQQFPTG VAPAPVLMNQ PPQIAPKRER KTIRIRDPNQ
110 120 130 140 150
GGKDITEEIM SGARTASTPT PPQTGGGLEP QANGETPQVA VIVRPDDRSQ
160 170 180 190 200
GAIIADRPGL PGPEHSPSES QPSSPSPTPS PSPVLEPGSE PNLAVLSIPG
210 220 230 240 250
DTMTTIQMSV EESTPISRET GEPYRLSPEP TPLAEPILEV EVTLSKPVPE
260 270 280 290 300
SEFSSSPLQA PTPLASHTVE IHEPNGMVPS EDLEPEVESS PELAPPPACP
310 320 330 340 350
SESPVPIAPT AQPEELLNGA PSPPAVDLSP VSEPEEQAKE VTASMAPPTI
360 370 380 390 400
PSATPATAPS ATSPAQEEEM EEEEEEEEGE AGEAGEAESE KGGEELLPPE
410 420 430 440 450
STPIPANLSQ NLEAAAATQV AVSVPKRRRK IKELNKKEAV GDLLDAFKEA
460 470 480 490 500
NPAVPEVENQ PPAGSNPGPE SEGSGVPPRP EEADETWDSK EDKIHNAENI
510 520 530 540 550
QPGEQKYEYK SDQWKPLNLE EKKRYDREFL LGFQFIFASM QKPEGLPHIS
560 570 580 590 600
DVVLDKANKT PLRPLDPTRL QGINCGPDFT PSFANLGRTT LSTRGPPRGG
610 620 630 640 650
PGGELPRGPA GLGPRRSQQG PRKEPRKIIA TVLMTEDIKL NKAEKAWKPS
660 670 680 690 700
SKRTPADKDR GEEDADGSKT QDLFRRVRSI LNKLTPQMFQ QLMKQVTQLA
710 720 730 740 750
IDTEERLKGV IDLIFEKAIS EPNFSVAYAN MCRCLMALKV PTTEKPTVTV
760 770 780 790 800
NFRKLLLNRC QKEFEKDKDD DEVFEKKQKE MDEAATAEER GRLKEELEEA
810 820 830 840 850
RDIARRRSLG NIKFIGELFK LKMLTEAIMH DCVVKLLKNH DEESLECLCR
860 870 880 890 900
LLTTIGKDLD FEKAKPRMDQ YFNQMEKIIK EKKTSSRIRF MLQDVLNLRG
910 920 930 940 950
SNWVPRRGDQ GPKTIDQIHK EAEMEEHREH IKVQQLMAKG SDKRRGGPPG
960 970 980 990 1000
PPISRGLPLV DDGGWNTVPI SKGSRPIDTS RLTKITKPGS IDSNNQLFAP
1010 1020 1030 1040 1050
GGRLSWGKGS SGGSGAKPSD AASEAARPAT STLNRFSALQ QAVPTESTDN
1060 1070 1080 1090 1100
RRVVQRSSLS RERGEKAGDR GDRLERSERG GDRGDRLDRA RTPATKRSFS
1110 1120 1130 1140 1150
KEVEERSRER PSQPEGLRKA ASLTEDRDRG RDAVKREAAL PPVSPLKAAL
1160 1170 1180 1190 1200
SEEELEKKSK AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGVESTL
1210 1220 1230 1240 1250
ERSAIAREHM GQLLHQLLCA GHLSTAQYYQ GLYEILELAE DVEIDIPHVW
1260 1270 1280 1290 1300
LYLAELVTPI LQEGGVPMGE LFREITKPLR PLGKAASLLL EILGLLCKSM
1310 1320 1330 1340 1350
GPKKVGTLWR EAGLSWKEFL PEGQDIGAFV AEQKVEYTLG EESEAPGQRA
1360 1370 1380 1390 1400
LPSEELNRQL EKLLKEGSSN QRVFDWIEAN LSEQQIVSNT LVRALMTAVC
1410 1420 1430 1440 1450
YSAIIFETPL RVDVAVLKAR AKLLQKYLCD EQKELQALYA LQALVVTLEQ
1460 1470 1480 1490 1500
PPNLLRMFFD ALYDEDVVKE DAFYSWESSK DPAEQQGKGV ALKSVTAFFK
1510
WLREAEEESD HN
Length:1,512
Mass (Da):166,582
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i790466ADA55CBC6D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK299763 mRNA Translation: BAG61651.1

NCBI Reference Sequences

More...
RefSeqi
NP_937887.1, NM_198244.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1981

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299763 mRNA Translation: BAG61651.1
RefSeqiNP_937887.1, NM_198244.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4DSI9
PRIDEiB4DSI9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1981

Genome annotation databases

GeneIDi1981

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1981

Phylogenomic databases

OMAiPRGGPNM

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1981, 570 hits in 1002 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1981

Gene expression databases

GenevisibleiB4DSI9, HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253:SF10, PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DSI9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DSI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 2, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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