UniProtKB - B4DRT6 (B4DRT6_HUMAN)
Protein
Uracil-DNA glycosylase
Gene
UNG
Organism
Homo sapiens (Human)
Status
Functioni
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation
Catalytic activityi
- Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation EC:3.2.2.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 111 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- uracil DNA N-glycosylase activity Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)Short name: UDGUniRule annotation |
Gene namesi | Name:UNGUniRule annotation Synonyms:UNG1UniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotation
Nucleus
- Nucleus UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionUniRule annotation, NucleusUniRule annotationInteractioni
Subunit structurei
Monomer.
Interacts with FAM72A.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 257 | UDGInterPro annotationAdd BLAST | 162 |
Sequence similaritiesi
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationARBA annotation
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
HAMAPi | MF_00148, UDG, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DRT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVFCLGPWG LGRKLRTPGK GPLSAEQLDR IQRNKAAALL RLAARNVPVG
60 70 80 90 100
FGESWKKHLS GEFGKPYFIK LMGFVAEERK HYTVYPPPHQ VFTWTQMCDI
110 120 130 140 150
KDVKVVILGQ DPYHGPNQAH GLCFSVQRPV PPPPSLENIY KELSTDIEDF
160 170 180 190 200
VHPGHGDLSG WAKQGVLLLN AVLTVRAHQA NSHKERGWEQ FTDAVVSWLN
210 220 230 240 250
QNSNGLVFLL WGSYAQKKGS AIDRKRHHVL QTAHPSPLSV YRGFFGCRHF
260 270
SKTNELLQKS GKKPIDWKEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299416 mRNA Translation: BAG61398.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299416 mRNA Translation: BAG61398.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B4DRT6 |
PeptideAtlasi | B4DRT6 |
ProteomicsDBi | 4974 |
Miscellaneous databases
ChiTaRSi | UNG, human |
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
HAMAPi | MF_00148, UDG, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DRT6_HUMAN | |
Accessioni | B4DRT6Primary (citable) accession number: B4DRT6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | August 12, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |