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Entry version 62 (12 Aug 2020)
Sequence version 1 (23 Sep 2008)
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Protein

DNA-directed RNA polymerase subunit beta

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotationImportedARBA annotation

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    PeptideAtlas

    More...
    PeptideAtlasi
    B4DR40

    PRoteomics IDEntifications database

    More...
    PRIDEi
    B4DR40

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 350RNA_pol_Rpb2_1InterPro annotationAdd BLAST331
    Domaini110 – 303RNA_pol_Rpb2_2InterPro annotationAdd BLAST194
    Domaini377 – 441RNA_pol_Rpb2_3InterPro annotationAdd BLAST65
    Domaini476 – 538RNA_pol_Rpb2_4InterPro annotationAdd BLAST63
    Domaini562 – 609RNA_pol_Rpb2_5InterPro annotationAdd BLAST48
    Domaini616 – 989RNA_pol_Rpb2_6InterPro annotationAdd BLAST374
    Domaini991 – 1081RNA_pol_Rpb2_7InterPro annotationAdd BLAST91

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotationARBA annotation

    Keywords - Domaini

    Zinc-fingerARBA annotation

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00653, RNA_pol_B_RPB2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015712, DNA-dir_RNA_pol_su2
    IPR007120, DNA-dir_RNAP_su2_dom
    IPR037033, DNA-dir_RNAP_su2_hyb_sf
    IPR007121, RNA_pol_bsu_CS
    IPR007644, RNA_pol_bsu_protrusion
    IPR007642, RNA_pol_Rpb2_2
    IPR037034, RNA_pol_Rpb2_2_sf
    IPR007645, RNA_pol_Rpb2_3
    IPR007646, RNA_pol_Rpb2_4
    IPR007647, RNA_pol_Rpb2_5
    IPR007641, RNA_pol_Rpb2_7
    IPR014724, RNA_pol_RPB2_OB-fold

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR20856, PTHR20856, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04563, RNA_pol_Rpb2_1, 1 hit
    PF04561, RNA_pol_Rpb2_2, 1 hit
    PF04565, RNA_pol_Rpb2_3, 1 hit
    PF04566, RNA_pol_Rpb2_4, 1 hit
    PF04567, RNA_pol_Rpb2_5, 1 hit
    PF00562, RNA_pol_Rpb2_6, 1 hit
    PF04560, RNA_pol_Rpb2_7, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01166, RNA_POL_BETA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    B4DR40-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRICNMMRMM MKSPRICGKK HARLRNLTYS APLYVDITKT VIKEGEEQLQ
    60 70 80 90 100
    TQHQKTFIGK IPIMLRSTYC LLNGLTDRDL CELNECPLDP GGYFIINGSE
    110 120 130 140 150
    KVLIAQEKMA TNTVYVFAKK DSKYAYTGEC RSCLENSSRP TSTIWVSMLA
    160 170 180 190 200
    RGGQGAKKSA IGQRIVATLP YIKQEVPIII VFRALGFVSD RDILEHIIYD
    210 220 230 240 250
    FEDPEMMEMV KPSLDEAFVI QEQNVALNFI GSRGAKPGVT KEKRIKYAKE
    260 270 280 290 300
    VLQKEMLPHV GVSDFCETKK AYFLGYMVHR LLLAALGRRE LDDRDHYGNK
    310 320 330 340 350
    RLDLAGPLLA FLFRGMFKNL LKEVRIYAQK FIDRGKDFNL ELAIKTRIIS
    360 370 380 390 400
    DGLKYSLATG NWGDQKKAHQ ARAGVSQVLN RLTFASTLSH LRRLNSPIGR
    410 420 430 440 450
    DGKLAKPRQL HNTLWGMVCP AETPEGHAVG LVKNLALMAY ISVGSQPSPI
    460 470 480 490 500
    LEFLEEWSME NLEEISPAAI ADATKIFVNG CWVGIHKDPE QLMNTLRKLR
    510 520 530 540 550
    RQMDIIVSEV SMIRDIRERE IRIYTDAGRI CRPLLIVEKQ KLLLKKRHID
    560 570 580 590 600
    QLKEREYNNY SWQDLVASGV VEYIDTLEEE TVMLAMTPDD LQEKEVAYCS
    610 620 630 640 650
    TYTHCEIHPS MILGVCASII PFPDHNQSPR NTYQSAMGKQ AMGVYITNFH
    660 670 680 690 700
    VRMDTLAHVL YYPQKPLVTT RSMEYLRFRE LPAGINSIVA IASYTGYNQE
    710 720 730 740 750
    DSVIMNRSAV DRGFFRSVFY RSYKEQESKK GFDQEEVFEK PTRETCQGMR
    760 770 780 790 800
    HAIYDKLDDD GLIAPGVRVS GDDVIISKTV TLPENEDELE STNRRYTKRD
    810 820 830 840 850
    CSTFLRTSET GIVDQVMVTL NQEGYKFCKI RVRSVRIPQI GDKFASRHGQ
    860 870 880 890 900
    KGTCGIQYRQ EDMPFTCEGI TPDIIINPHA IPSRMTIGHL IECLQGKVSA
    910 920 930 940 950
    NKGEIGDATP FNDAVNVQKI SNLLSDYGYH LRGNEVLYNG FTGRKITSQI
    960 970 980 990 1000
    FIGPTYYQRL KHMVDDKIHS RARGPIQILN RQPMEGRSRD GGLRFGEMER
    1010 1020 1030 1040 1050
    DCQIAHGAAQ FLRERLFEAS DPYQVHVCNL CGIMAIANTR THTYECRGCR
    1060 1070 1080
    NKTQISLVRM PYACKLLFQE LMSMSIAPRM MSV
    Length:1,083
    Mass (Da):123,365
    Last modified:September 23, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB34638096BFFEBFC
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK299090 mRNA Translation: BAG61152.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK299090 mRNA Translation: BAG61152.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Proteomic databases

    PeptideAtlasiB4DR40
    PRIDEiB4DR40

    Family and domain databases

    CDDicd00653, RNA_pol_B_RPB2, 1 hit
    Gene3Di2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit
    InterProiView protein in InterPro
    IPR015712, DNA-dir_RNA_pol_su2
    IPR007120, DNA-dir_RNAP_su2_dom
    IPR037033, DNA-dir_RNAP_su2_hyb_sf
    IPR007121, RNA_pol_bsu_CS
    IPR007644, RNA_pol_bsu_protrusion
    IPR007642, RNA_pol_Rpb2_2
    IPR037034, RNA_pol_Rpb2_2_sf
    IPR007645, RNA_pol_Rpb2_3
    IPR007646, RNA_pol_Rpb2_4
    IPR007647, RNA_pol_Rpb2_5
    IPR007641, RNA_pol_Rpb2_7
    IPR014724, RNA_pol_RPB2_OB-fold
    PANTHERiPTHR20856, PTHR20856, 1 hit
    PfamiView protein in Pfam
    PF04563, RNA_pol_Rpb2_1, 1 hit
    PF04561, RNA_pol_Rpb2_2, 1 hit
    PF04565, RNA_pol_Rpb2_3, 1 hit
    PF04566, RNA_pol_Rpb2_4, 1 hit
    PF04567, RNA_pol_Rpb2_5, 1 hit
    PF00562, RNA_pol_Rpb2_6, 1 hit
    PF04560, RNA_pol_Rpb2_7, 1 hit
    PROSITEiView protein in PROSITE
    PS01166, RNA_POL_BETA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DR40_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DR40
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: August 12, 2020
    This is version 62 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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