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UniProtKB - B4DP61 (B4DP61_HUMAN)
Protein
Submitted name:
Survival motor neuron protein
Gene
SMN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: InterPro
GO - Biological processi
- mRNA processing Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Survival motor neuron proteinSubmitted name: cDNA FLJ60754, moderately similar to Survival motor neuron proteinImported |
Gene namesi | Name:SMN1 Synonyms:SMN2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11117, SMN1 HGNC:11118, SMN2 |
VEuPathDBi | HostDB:ENSG00000172062 HostDB:ENSG00000205571 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000172062 ENSG00000205571 |
Chemistry databases
DrugBanki | DB13161, Nusinersen |
Expressioni
Gene expression databases
Bgeei | ENSG00000172062, Expressed in ventricular zone and 113 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 90 – 223 | SMNInterPro annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 54 – 162 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 81 – 120 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 123 – 162 | Pro residuesSequence analysisAdd BLAST | 40 |
Phylogenomic databases
GeneTreei | ENSGT00940000153352 |
Family and domain databases
InterProi | View protein in InterPro IPR010304, SMN_Tudor |
Pfami | View protein in Pfam PF06003, SMN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
B4DP61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF
60 70 80 90 100
KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QNENESQVST
110 120 130 140 150
DESENSRSPG NKSDNIKPKS APWNSFLPPP PPMPGPRLGP GKPGLKFNGP
160 170 180 190 200
PPPPPPPPPH LLSCWLPPFP SGPPIIPPPP PICPDSLDDA DALGSMLISW
210 220
YMSGYHTGYY MGFRQNQKEG RCSHSLN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ16637 | SMN_HUMAN | Survival motor neuron protein | SMN1 SMN, SMNT SMN2 SMNC | 294 | Annotation score: | ||
E7EQZ4 | E7EQZ4_HUMAN | Survival motor neuron protein | SMN1 SMN2 | 294 | Annotation score: | ||
A0A1W2PRV5 | A0A1W2PRV5_HUMAN | Survival motor neuron protein | SMN2 | 282 | Annotation score: | ||
A0A0G2JQN8 | A0A0G2JQN8_HUMAN | Survival motor neuron protein | SMN1 | 149 | Annotation score: | ||
A0A0G2JRX5 | A0A0G2JRX5_HUMAN | Survival motor neuron protein | SMN1 | 143 | Annotation score: | ||
A0A0G2JRY6 | A0A0G2JRY6_HUMAN | Survival motor neuron protein | SMN1 | 180 | Annotation score: | ||
H0YBZ9 | H0YBZ9_HUMAN | Survival motor neuron protein | SMN2 SMN1 | 79 | Annotation score: | ||
U3KPX7 | U3KPX7_HUMAN | Survival motor neuron protein | SMN2 | 46 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC044797 Genomic DNA No translation available. AC139494 Genomic DNA No translation available. AC139834 Genomic DNA No translation available. AC140134 Genomic DNA No translation available. AC244260 Genomic DNA No translation available. AC244635 Genomic DNA No translation available. AK298203 mRNA Translation: BAG60473.1 |
RefSeqi | XP_011541899.1, XM_011543597.1 XP_011541902.1, XM_011543600.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC044797 Genomic DNA No translation available. AC139494 Genomic DNA No translation available. AC139834 Genomic DNA No translation available. AC140134 Genomic DNA No translation available. AC244260 Genomic DNA No translation available. AC244635 Genomic DNA No translation available. AK298203 mRNA Translation: BAG60473.1 |
RefSeqi | XP_011541899.1, XM_011543597.1 XP_011541902.1, XM_011543600.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B4DP61, 2 interactors |
Chemistry databases
DrugBanki | DB13161, Nusinersen |
Proteomic databases
ProteomicsDBi | 4761 |
Protocols and materials databases
Antibodypediai | 12087, 382 antibodies from 24 providers 3991, 301 antibodies from 35 providers |
DNASUi | 6606 |
Genome annotation databases
Organism-specific databases
CTDi | 6606 6607 |
HGNCi | HGNC:11117, SMN1 HGNC:11118, SMN2 |
OpenTargetsi | ENSG00000172062 ENSG00000205571 |
VEuPathDBi | HostDB:ENSG00000172062 HostDB:ENSG00000205571 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153352 |
Miscellaneous databases
BioGRID-ORCSi | 6606, 35 hits in 247 CRISPR screens 6607, 402 hits in 609 CRISPR screens |
ChiTaRSi | SMN1, human |
Gene expression databases
Bgeei | ENSG00000172062, Expressed in ventricular zone and 113 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR010304, SMN_Tudor |
Pfami | View protein in Pfam PF06003, SMN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DP61_HUMAN | |
Accessioni | B4DP61Primary (citable) accession number: B4DP61 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |